Microtubules and Microtubule-Associated Proteins

Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules ar...

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Vydané v:Cold Spring Harbor perspectives in biology Ročník 10; číslo 6
Hlavní autori: Goodson, Holly V, Jonasson, Erin M
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.06.2018
Predmet:
Animals
Microtubule-Associated Proteins - chemistry
Microtubule-Associated Proteins - physiology
Microtubules - chemistry
Microtubules - physiology
Mitosis - physiology
Models, Molecular
Protein Conformation
ISSN:1943-0264, 1943-0264
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Shrnutí:Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules are "dynamic." As with actin, the polymer dynamics are driven by nucleotide hydrolysis and influenced by a host of specialized regulatory proteins, including microtubule-associated proteins. However, microtubule turnover involves a surprising behavior-termed dynamic instability-in which individual polymers switch stochastically between growth and depolymerization. Dynamic instability allows microtubules to explore intracellular space and remodel in response to intracellular and extracellular cues. Here, we review how such instability is central to the assembly of many microtubule-based structures and to the robust functioning of the microtubule cytoskeleton.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
content type line 23
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a022608