Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration

The intestinal epithelium continually self-renews and can rapidly regenerate after damage. Lgr5 marks mitotically active intestinal stem cells (ISCs). Importantly, intestinal homeostasis can be maintained after depletion of Lgr5(+) cells due to the activation of Lgr5(-) reserve ISCs. The Lgr5(-) ISC...

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Veröffentlicht in:	Cell stem cell Jg. 14; H. 2; S. 149
Hauptverfasser:	Metcalfe, Ciara, Kljavin, Noelyn M, Ybarra, Ryan, de Sauvage, Frederic J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 06.02.2014
Schlagworte:	Adenomatous Polyposis Coli Protein - metabolism Animals Colitis - chemically induced Colitis - pathology Dextran Sulfate Diphtheria Toxin - pharmacology Dose-Response Relationship, Radiation Hyperplasia Intestines - drug effects Intestines - physiology Intestines - radiation effects Mice Models, Animal Paneth Cells - cytology Paneth Cells - drug effects Paneth Cells - radiation effects Radiation, Ionizing Receptors, G-Protein-Coupled - metabolism Regeneration - drug effects Regeneration - radiation effects Stem Cells - cytology Stem Cells - drug effects Stem Cells - radiation effects
ISSN:	1875-9777, 1875-9777
Online-Zugang:	Weitere Angaben
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