Mitochondrial Genome Variation Affects Multiple Respiration and Nonrespiration Phenotypes in Saccharomyces cerevisiae

Mitochondrial genome variation and its effects on phenotypes have been widely analyzed in higher eukaryotes but less so in the model eukaryote Saccharomyces cerevisiae. Here, we describe mitochondrial genome variation in 96 diverse S. cerevisiae strains and assess associations between mitochondrial...

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Veröffentlicht in:	Genetics (Austin) Jg. 211; H. 2; S. 773 - 786
Hauptverfasser:	Vijayraghavan, Sriram, Kozmin, Stanislav G, Strope, Pooja K, Skelly, Daniel A, Lin, Zhenguo, Kennell, John, Magwene, Paul M, Dietrich, Fred S, McCusker, John H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Genetics Society of America 01.02.2019
Schlagworte:	Antifungal Agents - toxicity ATP synthase ATP6 protein Cell Respiration - genetics Copper - toxicity Cycloheximide Cycloheximide - toxicity Deoxyribonucleic acid Disease DNA Drug Resistance, Fungal - genetics Electron transport Epistasis Epistasis, Genetic Eukaryotes Gene expression Genetics Genome, Mitochondrial Genomes Genomics Genotype & phenotype Genotypes Hemizygosity Investigations Ketoconazole Ketoconazole - toxicity Mitochondria Mitochondrial DNA Mitochondrial Proton-Translocating ATPases - genetics Mutation Oligomycin Phenotype Phenotypes Polymorphism, Genetic Polymorphism, Single Nucleotide Proteins Quantitative genetics Respiration Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Single-nucleotide polymorphism Strains (organisms) Transfer RNA Variation Yeast mitochondrial genome variation transgression Introgression Saccharomyces cerevisiae phenotypic variation nuclear-mitochondrial epistasis
ISSN:	1943-2631, 0016-6731, 1943-2631
Online-Zugang:	Volltext
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