Principles for Integrative Structural Biology Studies

Integrative structure determination is a powerful approach to modeling the structures of biological systems based on data produced by multiple experimental and theoretical methods, with implications for our understanding of cellular biology and drug discovery. This Primer introduces the theory and m...

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Vydané v:Cell Ročník 177; číslo 6; s. 1384
Hlavní autori: Rout, Michael P, Sali, Andrej
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 30.05.2019
Predmet:
Algorithms
Animals
Computational Biology - methods
Humans
Models, Molecular
Molecular Biology
Nuclear Pore - physiology
Software
Systems Analysis
Systems Biology - methods
Systems Integration
ISSN:1097-4172, 1097-4172
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Popis
Shrnutí:Integrative structure determination is a powerful approach to modeling the structures of biological systems based on data produced by multiple experimental and theoretical methods, with implications for our understanding of cellular biology and drug discovery. This Primer introduces the theory and methods of integrative approaches, emphasizing the kinds of data that can be effectively included in developing models and using the nuclear pore complex as an example to illustrate the practice and challenges involved. These guidelines are intended to aid the researcher in understanding and applying integrative structural methods to systems of their interest and thus take advantage of this rapidly evolving field.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2019.05.016