Principles for Integrative Structural Biology Studies

Integrative structure determination is a powerful approach to modeling the structures of biological systems based on data produced by multiple experimental and theoretical methods, with implications for our understanding of cellular biology and drug discovery. This Primer introduces the theory and m...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell Jg. 177; H. 6; S. 1384
Hauptverfasser: Rout, Michael P, Sali, Andrej
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 30.05.2019
Schlagworte:
Algorithms
Animals
Computational Biology - methods
Humans
Models, Molecular
Molecular Biology
Nuclear Pore - physiology
Software
Systems Analysis
Systems Biology - methods
Systems Integration
ISSN:1097-4172, 1097-4172
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Integrative structure determination is a powerful approach to modeling the structures of biological systems based on data produced by multiple experimental and theoretical methods, with implications for our understanding of cellular biology and drug discovery. This Primer introduces the theory and methods of integrative approaches, emphasizing the kinds of data that can be effectively included in developing models and using the nuclear pore complex as an example to illustrate the practice and challenges involved. These guidelines are intended to aid the researcher in understanding and applying integrative structural methods to systems of their interest and thus take advantage of this rapidly evolving field.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2019.05.016