Enhanced Tendon-to-Bone Healing of Chronic Rotator Cuff Tears by Bone Marrow Aspirate Concentrate in a Rabbit Model

To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC. In this study, 40 rabbits were allocated into five groups: control (C), repair + saline (RS), repair + platelet...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Clinics in orthopedic surgery Ročník 10; číslo 1; s. 99 - 110
Hlavní autori:	Liu, Xiao Ning, Yang, Cheol-Jung, Kim, Ji Eui, Du, Zhen Wu, Ren, Ming, Zhang, Wei, Zhao, Hong Yu, Kim, Kyung Ok, Noh, Kyu-Cheol
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Korea (South) The Korean Orthopaedic Association 01.03.2018 대한정형외과학회
Predmet:	Animals Arthroplasty Biomechanical Phenomena Bone and Bones - physiopathology Bone Marrow - metabolism Chronic Disease Disease Models, Animal Elastic Modulus Insulin-Like Growth Factor I - metabolism Male Original Platelet-Derived Growth Factor - metabolism Platelet-Rich Plasma - metabolism Rabbits Rotator Cuff Injuries - pathology Rotator Cuff Injuries - therapy Shoulder Joint - physiopathology Shoulder Joint - surgery Tendons - physiopathology Transforming Growth Factor beta1 - metabolism Vascular Endothelial Growth Factor A - metabolism Wound Healing 정형외과학 Bone marrow Platelet-rich plasma Rotator cuff
ISSN:	2005-291X, 2005-4408, 2005-4408
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC. In this study, 40 rabbits were allocated into five groups: control (C), repair + saline (RS), repair + platelet-rich plasma (PRP; RP), repair + BMAC (RB) and repair + PRP + BMAC (RPB). A tear model was created by supraspinatus tendon transection at the footprint. Six weeks after transection, the torn tendon was repaired along with BMAC or PRP administration. Six weeks after repair, shoulder samples were harvested for biomechanical and histological testing. Ten rabbits were used for processing PRP and BMAC, followed by analysis of blood cell composition and the levels of growth factors . The ultimate load-to-failure was significantly higher in RPB group compared to RS group ( = 0.025). BMAC-treated groups showed higher values of biomechanical properties than RS group. The histology of BMAC-treated samples showed better collagen fiber continuity and orientation than RS group. BMAC contained significantly higher levels of the several growth factors than PRP. Locally administered BMAC enhanced tendon-to-bone healing and has potential for clinical applications.
AbstractList	To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC.BACKGROUNDTo evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC.In this in vivo study, 40 rabbits were allocated into five groups: control (C), repair + saline (RS), repair + platelet-rich plasma (PRP; RP), repair + BMAC (RB) and repair + PRP + BMAC (RPB). A tear model was created by supraspinatus tendon transection at the footprint. Six weeks after transection, the torn tendon was repaired along with BMAC or PRP administration. Six weeks after repair, shoulder samples were harvested for biomechanical and histological testing. Ten rabbits were used for processing PRP and BMAC, followed by analysis of blood cell composition and the levels of growth factors in vitro.METHODSIn this in vivo study, 40 rabbits were allocated into five groups: control (C), repair + saline (RS), repair + platelet-rich plasma (PRP; RP), repair + BMAC (RB) and repair + PRP + BMAC (RPB). A tear model was created by supraspinatus tendon transection at the footprint. Six weeks after transection, the torn tendon was repaired along with BMAC or PRP administration. Six weeks after repair, shoulder samples were harvested for biomechanical and histological testing. Ten rabbits were used for processing PRP and BMAC, followed by analysis of blood cell composition and the levels of growth factors in vitro.The ultimate load-to-failure was significantly higher in RPB group compared to RS group (p = 0.025). BMAC-treated groups showed higher values of biomechanical properties than RS group. The histology of BMAC-treated samples showed better collagen fiber continuity and orientation than RS group. BMAC contained significantly higher levels of the several growth factors than PRP.RESULTSThe ultimate load-to-failure was significantly higher in RPB group compared to RS group (p = 0.025). BMAC-treated groups showed higher values of biomechanical properties than RS group. The histology of BMAC-treated samples showed better collagen fiber continuity and orientation than RS group. BMAC contained significantly higher levels of the several growth factors than PRP.Locally administered BMAC enhanced tendon-to-bone healing and has potential for clinical applications.CONCLUSIONSLocally administered BMAC enhanced tendon-to-bone healing and has potential for clinical applications. To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC. In this study, 40 rabbits were allocated into five groups: control (C), repair + saline (RS), repair + platelet-rich plasma (PRP; RP), repair + BMAC (RB) and repair + PRP + BMAC (RPB). A tear model was created by supraspinatus tendon transection at the footprint. Six weeks after transection, the torn tendon was repaired along with BMAC or PRP administration. Six weeks after repair, shoulder samples were harvested for biomechanical and histological testing. Ten rabbits were used for processing PRP and BMAC, followed by analysis of blood cell composition and the levels of growth factors . The ultimate load-to-failure was significantly higher in RPB group compared to RS group ( = 0.025). BMAC-treated groups showed higher values of biomechanical properties than RS group. The histology of BMAC-treated samples showed better collagen fiber continuity and orientation than RS group. BMAC contained significantly higher levels of the several growth factors than PRP. Locally administered BMAC enhanced tendon-to-bone healing and has potential for clinical applications. Background: To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC. Methods: In this in vivo study, 40 rabbits were allocated into five groups: control (C), repair + saline (RS), repair + platelet-rich plasma (PRP; RP), repair + BMAC (RB) and repair + PRP + BMAC (RPB). A tear model was created by supraspinatus tendon transection at the footprint. Six weeks after transection, the torn tendon was repaired along with BMAC or PRP administration. Six weeks after repair, shoulder samples were harvested for biomechanical and histological testing. Ten rabbits were used for processing PRP and BMAC, followed by analysis of blood cell composition and the levels of growth factors in vitro . Results: The ultimate load-to-failure was significantly higher in RPB group compared to RS group (p = 0.025). BMAC-treated groups showed higher values of biomechanical properties than RS group. The histology of BMAC-treated samples showed better collagen fiber continuity and orientation than RS group. BMAC contained significantly higher levels of the several growth factors than PRP. Conclusions: Locally administered BMAC enhanced tendon-to-bone healing and has potential for clinical applications. KCI Citation Count: 0
Author	Du, Zhen Wu Kim, Kyung Ok Zhang, Wei Noh, Kyu-Cheol Kim, Ji Eui Zhao, Hong Yu Ren, Ming Liu, Xiao Ning Yang, Cheol-Jung
AuthorAffiliation	Gachon Medical Research Institute, Gil Medical Center, Gachon University, Incheon, Korea Department of Orthopedic Surgery, The Armed Forces Daejeon Hospital, Daejeon, Korea Department of Orthopaedic Surgery, The Second Hospital of Jilin University, Changchun, China Department of Orthopaedic Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
AuthorAffiliation_xml	– name: Gachon Medical Research Institute, Gil Medical Center, Gachon University, Incheon, Korea – name: Department of Orthopaedic Surgery, The Second Hospital of Jilin University, Changchun, China – name: Department of Orthopaedic Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea – name: Department of Orthopedic Surgery, The Armed Forces Daejeon Hospital, Daejeon, Korea
Author_xml	– sequence: 1 givenname: Xiao Ning surname: Liu fullname: Liu, Xiao Ning organization: Department of Orthopaedic Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea., Department of Orthopaedic Surgery, The Second Hospital of Jilin University, Changchun, China – sequence: 2 givenname: Cheol-Jung surname: Yang fullname: Yang, Cheol-Jung organization: Department of Orthopaedic Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea., Department of Orthopedic Surgery, The Armed Forces Daejeon Hospital, Daejeon, Korea – sequence: 3 givenname: Ji Eui surname: Kim fullname: Kim, Ji Eui organization: Department of Orthopaedic Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea – sequence: 4 givenname: Zhen Wu surname: Du fullname: Du, Zhen Wu organization: Department of Orthopaedic Surgery, The Second Hospital of Jilin University, Changchun, China – sequence: 5 givenname: Ming surname: Ren fullname: Ren, Ming organization: Department of Orthopaedic Surgery, The Second Hospital of Jilin University, Changchun, China – sequence: 6 givenname: Wei surname: Zhang fullname: Zhang, Wei organization: Department of Orthopaedic Surgery, The Second Hospital of Jilin University, Changchun, China – sequence: 7 givenname: Hong Yu surname: Zhao fullname: Zhao, Hong Yu organization: Department of Orthopaedic Surgery, The Second Hospital of Jilin University, Changchun, China – sequence: 8 givenname: Kyung Ok surname: Kim fullname: Kim, Kyung Ok organization: Gachon Medical Research Institute, Gil Medical Center, Gachon University, Incheon, Korea – sequence: 9 givenname: Kyu-Cheol surname: Noh fullname: Noh, Kyu-Cheol organization: Department of Orthopaedic Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29564054$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002320336$$DAccess content in National Research Foundation of Korea (NRF)
BookMark	eNp9kU9v1DAQxS1U1H_0A3BBPsIhix3biX1B2kaFVmqFtNpKvVkTx-maZu3FzoL67XF2lwo4cJrR-PfejPzO0JEP3iL0lpIZJ0J8NC6kWUmonOUJnSn1Cp2WhIiCcyKPDn2p6MMJOkvpGyGVqGpyjE5KJarswE9RuvIr8MZ2eGl9F3wxhuIyb8HXFgbnH3HocbOKwTuDF2GEMUTcbPs-4xATbp_xjr6DGMNPPE8bF2G0uAnZ04-73nkMeAFt60Z8Fzo7vEGvexiSvTjUc3T_-WrZXBe3X7_cNPPbwnDGxqJrFXSs7QhYQQ1wwkCwjgnDRNWXolYlkXUrS5NbC9BSJQ3jHQdqRUV5y87Rh72vj71-Mk4HcLv6GPRT1PPF8kazWsmSV5n9tGc323Ztu_3xg95Et4b4vFP-_eLdKvv80EIKKqsyG7w_GMTwfWvTqNcuGTsM4G3YJp1jqvOPV1xm9N2fu16W_E4lA3QPmBhSirZ_QSjRU_J6Sn6ylNOEaqWypv5HY1yOy4XpXDf8R_kLl0G0hA
CitedBy_id	crossref_primary_10_1016_j_ctcp_2018_11_005 crossref_primary_10_1007_s00142_025_00778_y crossref_primary_10_1177_23259671221127004 crossref_primary_10_1186_s40634_022_00468_w crossref_primary_10_1088_1758_5090_abd159 crossref_primary_10_1093_jbcr_irad080 crossref_primary_10_1016_j_otsm_2025_151188 crossref_primary_10_1371_journal_pone_0266030 crossref_primary_10_1016_j_arthro_2019_11_119 crossref_primary_10_1016_j_jse_2025_05_015 crossref_primary_10_1039_D0BM01222J crossref_primary_10_1177_03635465211030508 crossref_primary_10_1016_j_cej_2019_123671 crossref_primary_10_1016_j_arthro_2023_05_020 crossref_primary_10_1080_14712598_2021_1928630 crossref_primary_10_1016_j_jse_2019_07_025 crossref_primary_10_1177_03635465231154601 crossref_primary_10_1016_j_biomaterials_2021_120789 crossref_primary_10_1177_03635465241313124 crossref_primary_10_2106_JBJS_RVW_25_00007 crossref_primary_10_1016_j_arthro_2022_01_008 crossref_primary_10_1016_j_ijbiomac_2023_125421 crossref_primary_10_3389_fvets_2021_678453 crossref_primary_10_1177_23259671221150037 crossref_primary_10_3390_medicina61050853 crossref_primary_10_1016_j_eats_2021_11_021 crossref_primary_10_1016_j_ocl_2018_08_005 crossref_primary_10_1038_s41598_025_91972_3 crossref_primary_10_1002_jor_24941 crossref_primary_10_1016_j_pmr_2022_08_015 crossref_primary_10_1007_s11678_024_00838_z crossref_primary_10_1177_0363546519896350 crossref_primary_10_3390_ph17101366 crossref_primary_10_5397_cise_2024_01053 crossref_primary_10_1016_j_arthro_2021_11_031 crossref_primary_10_1016_j_jmbbm_2020_103782 crossref_primary_10_1039_C9BM00413K crossref_primary_10_1002_jeo2_12061 crossref_primary_10_1016_j_otsm_2020_150757 crossref_primary_10_1073_pnas_2012347117
Cites_doi	10.7326/0003-4819-153-4-201008170-00263 10.1007/s11999-010-1323-7 10.3109/2000656X.2012.752739 10.1016/j.biomaterials.2012.04.007 10.1177/0363546509339582 10.1002/jor.21317 10.1371/journal.pone.0040833 10.2106/JBJS.I.01325 10.4103/0970-0358.96599 10.1016/j.arthro.2007.01.023 10.1177/0363546509349921 10.1089/ten.tea.2007.0210 10.2106/00004623-199173070-00004 10.1177/0363546513503810 10.2217/17460751.1.4.563 10.2106/00004623-199909000-00009 10.4055/cios.2011.3.4.325 10.1007/s00402-011-1283-8 10.1177/0363546510376750 10.1002/jbm.b.33084 10.1080/00016470410001708190 10.1016/j.jse.2013.07.054 10.1016/j.biomaterials.2012.06.058 10.1007/s11999-007-0112-4 10.1007/s00402-009-0935-4 10.1177/0363546512452713 10.1002/jor.20980 10.1007/s00402-004-0663-8 10.1067/mse.2002.126760
ContentType	Journal Article
Copyright	Copyright © 2018 by The Korean Orthopaedic Association 2018 The Korean Orthopaedic Association
Copyright_xml	– notice: Copyright © 2018 by The Korean Orthopaedic Association 2018 The Korean Orthopaedic Association
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM ACYCR
DOI	10.4055/cios.2018.10.1.99
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) Korean Citation Index
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
EISSN	2005-4408
EndPage	110
ExternalDocumentID	oai_kci_go_kr_ARTI_3798246 PMC5851862 29564054 10_4055_cios_2018_10_1_99
Genre	Journal Article
GrantInformation_xml	– fundername: ;
GroupedDBID	--- 5-W 53G 8JR 8XY AAYXX ADBBV ADRAZ ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV C1A CITATION DIK E3Z EBD EF. EMOBN F5P FRP GROUPED_DOAJ HYE KQ8 M48 O5R O5S OK1 PGMZT RPM SV3 TR2 W2D 9ZL CGR CUY CVF ECM EIF M~E NPM 7X8 5PM ACYCR
ID	FETCH-LOGICAL-c433t-db9ad3bd0ae51ca403a53d35c356f25792087b82c579eaab198c34d4a1e5614b3
ISICitedReferencesCount	45
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000427104300015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2005-291X 2005-4408
IngestDate	Tue Nov 21 21:35:13 EST 2023 Tue Nov 04 02:01:36 EST 2025 Fri Jul 11 08:50:55 EDT 2025 Thu Jan 02 22:55:43 EST 2025 Tue Nov 18 22:22:44 EST 2025 Sat Nov 29 03:07:30 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	Bone marrow Platelet-rich plasma Rotator cuff
Language	English
License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c433t-db9ad3bd0ae51ca403a53d35c356f25792087b82c579eaab198c34d4a1e5614b3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	http://dx.doi.org/10.4055/cios.2018.10.1.99
PMID	29564054
PQID	2017054648
PQPubID	23479
PageCount	12
ParticipantIDs	nrf_kci_oai_kci_go_kr_ARTI_3798246 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5851862 proquest_miscellaneous_2017054648 pubmed_primary_29564054 crossref_primary_10_4055_cios_2018_10_1_99 crossref_citationtrail_10_4055_cios_2018_10_1_99
PublicationCentury	2000
PublicationDate	2018-03-01
PublicationDateYYYYMMDD	2018-03-01
PublicationDate_xml	– month: 03 year: 2018 text: 2018-03-01 day: 01
PublicationDecade	2010
PublicationPlace	Korea (South)
PublicationPlace_xml	– name: Korea (South)
PublicationTitle	Clinics in orthopedic surgery
PublicationTitleAlternate	Clin Orthop Surg
PublicationYear	2018
Publisher	The Korean Orthopaedic Association 대한정형외과학회
Publisher_xml	– name: The Korean Orthopaedic Association – name: 대한정형외과학회
References	Chung (10.4055/cios.2018.10.1.99_ref18) 2013; 41 Gerber (10.4055/cios.2018.10.1.99_ref5) 1999; 81 Zhang (10.4055/cios.2018.10.1.99_ref28) 2010; 38 Lorbach (10.4055/cios.2018.10.1.99_ref3) 2011; 131 Aspenberg (10.4055/cios.2018.10.1.99_ref26) 2004; 75 Oh (10.4055/cios.2018.10.1.99_ref13) 2014; 23 Hoffmann (10.4055/cios.2018.10.1.99_ref23) 2006; 1 Nishimoto (10.4055/cios.2018.10.1.99_ref30) 2013; 47 Xie (10.4055/cios.2018.10.1.99_ref9) 2012; 33 Cheung (10.4055/cios.2018.10.1.99_ref7) 2010; 468 Murphy (10.4055/cios.2018.10.1.99_ref8) 2012; 33 Kim (10.4055/cios.2018.10.1.99_ref10) 2011; 3 Livermore (10.4055/cios.2018.10.1.99_ref4) 2010; 39 Kovacevic (10.4055/cios.2018.10.1.99_ref6) 2008; 466 Nishimoto (10.4055/cios.2018.10.1.99_ref11) 2012; 45 Yun (10.4055/cios.2018.10.1.99_ref12) 2014; 102 Bosch (10.4055/cios.2018.10.1.99_ref27) 2010; 28 Hirose (10.4055/cios.2018.10.1.99_ref17) 2004; 124 Geuze (10.4055/cios.2018.10.1.99_ref22) 2008; 14 Lyras (10.4055/cios.2018.10.1.99_ref25) 2009; 129 Foster (10.4055/cios.2018.10.1.99_ref19) 2009; 37 Mazzocca (10.4055/cios.2018.10.1.99_ref29) 2012; 40 Uhthoff (10.4055/cios.2018.10.1.99_ref14) 2002; 11 Gulotta (10.4055/cios.2018.10.1.99_ref21) 2009; 37 Okamoto (10.4055/cios.2018.10.1.99_ref24) 2010; 92 Rubino (10.4055/cios.2018.10.1.99_ref15) 2007; 23 Itoigawa (10.4055/cios.2018.10.1.99_ref16) 2011; 29 Zhong (10.4055/cios.2018.10.1.99_ref20) 2012; 7 Harryman (10.4055/cios.2018.10.1.99_ref2) 1991; 73 Seida (10.4055/cios.2018.10.1.99_ref1) 2010; 153
References_xml	– volume: 153 start-page: 246 issue: 4 year: 2010 ident: 10.4055/cios.2018.10.1.99_ref1 publication-title: Ann Intern Med doi: 10.7326/0003-4819-153-4-201008170-00263 – volume: 468 start-page: 1476 issue: 6 year: 2010 ident: 10.4055/cios.2018.10.1.99_ref7 publication-title: Clin Orthop Relat Res doi: 10.1007/s11999-010-1323-7 – volume: 47 start-page: 169 issue: 3 year: 2013 ident: 10.4055/cios.2018.10.1.99_ref30 publication-title: J Plast Surg Hand Surg doi: 10.3109/2000656X.2012.752739 – volume: 33 start-page: 5308 issue: 21 year: 2012 ident: 10.4055/cios.2018.10.1.99_ref8 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2012.04.007 – volume: 37 start-page: 2126 issue: 11 year: 2009 ident: 10.4055/cios.2018.10.1.99_ref21 publication-title: Am J Sports Med doi: 10.1177/0363546509339582 – volume: 29 start-page: 861 issue: 6 year: 2011 ident: 10.4055/cios.2018.10.1.99_ref16 publication-title: J Orthop Res doi: 10.1002/jor.21317 – volume: 7 start-page: e40833 issue: 7 year: 2012 ident: 10.4055/cios.2018.10.1.99_ref20 publication-title: PLoS One doi: 10.1371/journal.pone.0040833 – volume: 92 start-page: 2776 issue: 17 year: 2010 ident: 10.4055/cios.2018.10.1.99_ref24 publication-title: J Bone Joint Surg Am doi: 10.2106/JBJS.I.01325 – volume: 45 start-page: 109 issue: 1 year: 2012 ident: 10.4055/cios.2018.10.1.99_ref11 publication-title: Indian J Plast Surg doi: 10.4103/0970-0358.96599 – volume: 23 start-page: 717 issue: 7 year: 2007 ident: 10.4055/cios.2018.10.1.99_ref15 publication-title: Arthroscopy doi: 10.1016/j.arthro.2007.01.023 – volume: 37 start-page: 2259 issue: 11 year: 2009 ident: 10.4055/cios.2018.10.1.99_ref19 publication-title: Am J Sports Med doi: 10.1177/0363546509349921 – volume: 14 start-page: 1435 issue: 8 year: 2008 ident: 10.4055/cios.2018.10.1.99_ref22 publication-title: Tissue Eng Part A doi: 10.1089/ten.tea.2007.0210 – volume: 73 start-page: 982 issue: 7 year: 1991 ident: 10.4055/cios.2018.10.1.99_ref2 publication-title: J Bone Joint Surg Am doi: 10.2106/00004623-199173070-00004 – volume: 41 start-page: 2909 issue: 12 year: 2013 ident: 10.4055/cios.2018.10.1.99_ref18 publication-title: Am J Sports Med doi: 10.1177/0363546513503810 – volume: 1 start-page: 563 issue: 4 year: 2006 ident: 10.4055/cios.2018.10.1.99_ref23 publication-title: Regen Med doi: 10.2217/17460751.1.4.563 – volume: 81 start-page: 1281 issue: 9 year: 1999 ident: 10.4055/cios.2018.10.1.99_ref5 publication-title: J Bone Joint Surg Am doi: 10.2106/00004623-199909000-00009 – volume: 3 start-page: 325 issue: 4 year: 2011 ident: 10.4055/cios.2018.10.1.99_ref10 publication-title: Clin Orthop Surg doi: 10.4055/cios.2011.3.4.325 – volume: 131 start-page: 1073 issue: 8 year: 2011 ident: 10.4055/cios.2018.10.1.99_ref3 publication-title: Arch Orthop Trauma Surg doi: 10.1007/s00402-011-1283-8 – volume: 38 start-page: 2477 issue: 12 year: 2010 ident: 10.4055/cios.2018.10.1.99_ref28 publication-title: Am J Sports Med doi: 10.1177/0363546510376750 – volume: 102 start-page: 1021 issue: 5 year: 2014 ident: 10.4055/cios.2018.10.1.99_ref12 publication-title: J Biomed Mater Res B Appl Biomater doi: 10.1002/jbm.b.33084 – volume: 75 start-page: 93 issue: 1 year: 2004 ident: 10.4055/cios.2018.10.1.99_ref26 publication-title: Acta Orthop Scand doi: 10.1080/00016470410001708190 – volume: 23 start-page: 445 issue: 4 year: 2014 ident: 10.4055/cios.2018.10.1.99_ref13 publication-title: J Shoulder Elbow Surg doi: 10.1016/j.jse.2013.07.054 – volume: 33 start-page: 7008 issue: 29 year: 2012 ident: 10.4055/cios.2018.10.1.99_ref9 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2012.06.058 – volume: 39 start-page: 569 issue: 12 year: 2010 ident: 10.4055/cios.2018.10.1.99_ref4 publication-title: Am J Orthop (Belle Mead NJ) – volume: 466 start-page: 622 issue: 3 year: 2008 ident: 10.4055/cios.2018.10.1.99_ref6 publication-title: Clin Orthop Relat Res doi: 10.1007/s11999-007-0112-4 – volume: 129 start-page: 1577 issue: 11 year: 2009 ident: 10.4055/cios.2018.10.1.99_ref25 publication-title: Arch Orthop Trauma Surg doi: 10.1007/s00402-009-0935-4 – volume: 40 start-page: 1742 issue: 8 year: 2012 ident: 10.4055/cios.2018.10.1.99_ref29 publication-title: Am J Sports Med doi: 10.1177/0363546512452713 – volume: 28 start-page: 211 issue: 2 year: 2010 ident: 10.4055/cios.2018.10.1.99_ref27 publication-title: J Orthop Res doi: 10.1002/jor.20980 – volume: 124 start-page: 374 issue: 6 year: 2004 ident: 10.4055/cios.2018.10.1.99_ref17 publication-title: Arch Orthop Trauma Surg doi: 10.1007/s00402-004-0663-8 – volume: 11 start-page: 504 issue: 5 year: 2002 ident: 10.4055/cios.2018.10.1.99_ref14 publication-title: J Shoulder Elbow Surg doi: 10.1067/mse.2002.126760
SSID	ssj0065670
Score	2.3379674
Snippet	To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the... Background: To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize...
SourceID	nrf pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	99
SubjectTerms	Animals Arthroplasty Biomechanical Phenomena Bone and Bones - physiopathology Bone Marrow - metabolism Chronic Disease Disease Models, Animal Elastic Modulus Insulin-Like Growth Factor I - metabolism Male Original Platelet-Derived Growth Factor - metabolism Platelet-Rich Plasma - metabolism Rabbits Rotator Cuff Injuries - pathology Rotator Cuff Injuries - therapy Shoulder Joint - physiopathology Shoulder Joint - surgery Tendons - physiopathology Transforming Growth Factor beta1 - metabolism Vascular Endothelial Growth Factor A - metabolism Wound Healing 정형외과학
Title	Enhanced Tendon-to-Bone Healing of Chronic Rotator Cuff Tears by Bone Marrow Aspirate Concentrate in a Rabbit Model
URI	https://www.ncbi.nlm.nih.gov/pubmed/29564054 https://www.proquest.com/docview/2017054648 https://pubmed.ncbi.nlm.nih.gov/PMC5851862 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002320336
Volume	10
WOSCitedRecordID	wos000427104300015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
ispartofPNX	Clinics in Orthopedic Surgery, 2018, 10(1), , pp.99-110
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2005-4408 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0065670 issn: 2005-291X databaseCode: DOA dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbWwQMvCMStXCaDyAtVRhLnYj-2XRE8MKFpiIqXyHHsNdqUTG06jX_POU7SpuOi8cBLdeQ4ttvva3wcH3-HkLcmyuNEs9z1tGGwQAk9l2tPuYqr0ORZlkglbbKJ5PiYz-fiy95gvzsLc3WRlCW_vhaX_xVqKAOw8ejsP8C9aRQKwAbQ4RNgh89bAT8rF82u_qnGTB1uXbmTClxJPHDUhji3irijk6rGNfdoujYGtZ2XK_RGbe3PVpwR0LMb8ZjbrmziOGurMiJHJzLLitrmUrvoe7iN0KiNssUtoeoSd4JGq97pa4B3XsgKSGgPWK27Qmc2dUTsCB-NSeCMPTTGoSP8bZWxMxEYnYFXktYQR47YROR-X-hy9G09Olr3X2j4fBvRZSnozCYOn9oG4O7IEVPbpIc2lnBrQNvCmXDbLXMm066ysMYYWtg-SK3aaiBsah6Y87ZlmG279_BuMjW1boDfRNvenGHAv0UxDlVUqPXu80OcdQ67O_tq3jdm2R0973NVpGdVer5MYdXyKWWJ4EEYD8idIImE6F4MNP4EONw25eHmWzR78ziQ978MY8e7GpRL87uF0834355DdfqA3G9XQnTcMPgh2dPlI7Lq2Et32Utb9tLK0Ja9tGUvRfZSy16a_aC2dsNe2rGX9thLi5JK2rCXWvY-Jl8_zE6nH902L4irQsZqN8-EzFmWe1JHvpKhx2TEchYpFsUGpiAReDzJeKDA1FJmvuCKhXkofY26txl7QvZLGMwzQkVsfC09luNrg0Aarv1MaWG0r5PEhGZIvO73TFUrmo-5Wy5SWDwjBClCkCIEWOKnQgzJu80tl41izN8qvwGQLB_-zIshed1hmMLDH3f0ZKmrtW0qgTVXHPIhedpguukzEFEMnYZDkuygvamAHe5eKYuFFZjHUAEeB89vM7gX5N72T_yS7NfLtX5F7qqrulgtD8ggmfMDy-efZ_vf8A
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Enhanced+Tendon-to-Bone+Healing+of+Chronic+Rotator+Cuff+Tears+by+Bone+Marrow+Aspirate+Concentrate+in+a+Rabbit+Model&rft.jtitle=Clinics+in+orthopedic+surgery&rft.au=Xiao+Ning+Liu&rft.au=%EC%96%91%EC%B2%A0%EC%A4%91&rft.au=%EA%B9%80%EC%A7%80%EC%9D%98&rft.au=Zhen+Wu+Du&rft.date=2018-03-01&rft.pub=%EB%8C%80%ED%95%9C%EC%A0%95%ED%98%95%EC%99%B8%EA%B3%BC%ED%95%99%ED%9A%8C&rft.issn=2005-291X&rft.eissn=2005-4408&rft.spage=99&rft.epage=110&rft_id=info:doi/10.4055%2Fcios.2018.10.1.99&rft.externalDBID=n%2Fa&rft.externalDocID=oai_kci_go_kr_ARTI_3798246
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2005-291X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2005-291X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2005-291X&client=summon