Enhanced Tendon-to-Bone Healing of Chronic Rotator Cuff Tears by Bone Marrow Aspirate Concentrate in a Rabbit Model

To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC. In this study, 40 rabbits were allocated into five groups: control (C), repair + saline (RS), repair + platelet...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Clinics in orthopedic surgery Ročník 10; číslo 1; s. 99 - 110
Hlavní autoři: Liu, Xiao Ning, Yang, Cheol-Jung, Kim, Ji Eui, Du, Zhen Wu, Ren, Ming, Zhang, Wei, Zhao, Hong Yu, Kim, Kyung Ok, Noh, Kyu-Cheol
Médium: Journal Article
Jazyk:angličtina
Vydáno: Korea (South) The Korean Orthopaedic Association 01.03.2018
대한정형외과학회
Témata:
Animals
Arthroplasty
Biomechanical Phenomena
Bone and Bones - physiopathology
Bone Marrow - metabolism
Chronic Disease
Disease Models, Animal
Elastic Modulus
Insulin-Like Growth Factor I - metabolism
Male
Original
Platelet-Derived Growth Factor - metabolism
Platelet-Rich Plasma - metabolism
Rabbits
Rotator Cuff Injuries - pathology
Rotator Cuff Injuries - therapy
Shoulder Joint - physiopathology
Shoulder Joint - surgery
Tendons - physiopathology
Transforming Growth Factor beta1 - metabolism
Vascular Endothelial Growth Factor A - metabolism
Wound Healing
정형외과학
Bone marrow
Platelet-rich plasma
Rotator cuff
ISSN:2005-291X, 2005-4408, 2005-4408
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC. In this study, 40 rabbits were allocated into five groups: control (C), repair + saline (RS), repair + platelet-rich plasma (PRP; RP), repair + BMAC (RB) and repair + PRP + BMAC (RPB). A tear model was created by supraspinatus tendon transection at the footprint. Six weeks after transection, the torn tendon was repaired along with BMAC or PRP administration. Six weeks after repair, shoulder samples were harvested for biomechanical and histological testing. Ten rabbits were used for processing PRP and BMAC, followed by analysis of blood cell composition and the levels of growth factors . The ultimate load-to-failure was significantly higher in RPB group compared to RS group ( = 0.025). BMAC-treated groups showed higher values of biomechanical properties than RS group. The histology of BMAC-treated samples showed better collagen fiber continuity and orientation than RS group. BMAC contained significantly higher levels of the several growth factors than PRP. Locally administered BMAC enhanced tendon-to-bone healing and has potential for clinical applications.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2005-291X
2005-4408
2005-4408
DOI:10.4055/cios.2018.10.1.99