Organ-specific electrophile responsivity mapping in live C. elegans

Proximity labeling technologies are limited to indexing localized protein residents. Such data-although valuable-cannot inform on small-molecule responsivity of local residents. We here bridge this gap by demonstrating in live C. elegans how electrophile-sensing propensity in specific organs can be...

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Vydané v:	Cell Ročník 187; číslo 26; s. 7450
Hlavní autori:	Liu, Jinmin, Kulkarni, Amogh, Gao, Yong-Qi, Urul, Daniel A, Hamelin, Romain, Novotny, Balázs Á, Long, Marcus J C, Aye, Yimon
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 26.12.2024
Predmet:	Animals Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - metabolism Cysteine - metabolism Cytochrome P-450 Enzyme System - metabolism Humans Organ Specificity Stress, Physiological reactive metabolite signaling tissue-specific stress response proximity labeling proteomics C. elegans organ-specific responsivity profiling cytochrome P450 4-hydroxynonenal function-guided spatial mapping
ISSN:	1097-4172, 1097-4172
On-line prístup:	Zistit podrobnosti o prístupe
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