Full angle spatial compounding for improved replenishment analyses in contrast perfusion imaging: In vitro studies

For contrast enhanced perfusion imaging semi-quantitative methods (such as the bolus-, replenishment- or depletion-method) are commonly used to analyze the dynamic changes in concentration of contrast agent induced by insonification. In order to apply these methods and to decrease artifacts from tis...

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Bibliographic Details
Published in:IEEE transactions on ultrasonics, ferroelectrics, and frequency control Vol. 55; no. 4; pp. 819 - 831
Main Authors: Hansen, C., Huttebrauker, N., Brunke, S., Ermert, H.
Format: Journal Article
Language:English
Published: New York, NY IEEE 01.04.2008
Institute of Electrical and Electronics Engineers
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:
Acoustics
Algorithms
Beams (radiation)
Biological and medical sciences
Biomedical engineering
Biomedical imaging
Compounding
Contrast agents
Contrast Media
Echo surveys
Exact sciences and technology
Fundamental areas of phenomenology (including applications)
General equipment and techniques
Image analysis
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging
Imaging, Three-Dimensional - methods
In vitro
Instruments, apparatus, components and techniques common to several branches of physics and astronomy
Investigative techniques, diagnostic techniques (general aspects)
Medical diagnostic imaging
Medical sciences
Methods
Miscellaneous. Technology
Perfusion - methods
Physics
Replenishment
Reproducibility of Results
Scattering
Sensitivity and Specificity
Shadow mapping
Spatial resolution
Speckle
Transducers
Ultrasonic imaging
Ultrasonic investigative techniques
Ultrasonics, quantum acoustics, and physical effects of sound
Ultrasonography - methods
Human
Pulse echo method
Image processing
Speckle
Artefact
Multiple view
Perfusion
Breast
Medical imagery
Diagnosis
Mammary gland
Non linear effect
Acoustic image
Isotropic material
Shadowing
Contrast media
Quantitative analysis
ISSN:0885-3010, 1525-8955
Online Access:Get full text
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Summary:For contrast enhanced perfusion imaging semi-quantitative methods (such as the bolus-, replenishment- or depletion-method) are commonly used to analyze the dynamic changes in concentration of contrast agent induced by insonification. In order to apply these methods and to decrease artifacts from tissue nonlinearity, perfusion imaging is conducted using decreased transmit power. However, echo signals from deeper structures are often too weak to be successfully analyzed. Furthermore, shadowing artifacts may occur as a result of high concentration of contrast agent in the beam path. Thus, those semi-quantitative methods often fail or yield ambiguous diagnoses. Imaging an object (e.g., the female breast) from multiple viewing angles (spatial compounding) may overcome these issues. In addition, spatial compounding achieves an isotropic resolution and reduces speckle and further common artifacts. In this paper we present results obtained from a combination of spatial compounding with contrast-enhanced perfusion imaging. Applying the replenishment method, we extracted perfusion-related parameters and compared the conventional parametric images with the compound parametric images. We found that the compounded parametric images outperform the conventional images due to reduced noise and suppression of artifacts.
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ISSN:0885-3010
1525-8955
DOI:10.1109/TUFFC.2008.716