Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand

The spontaneous action potential (AP) firing rate of sinoatrial node cells (SANCs) involves high-throughput signaling via Ca(2+)-calmodulin activated adenylyl cyclases (AC), cAMP-mediated protein kinase A (PKA), and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent phosphorylation of...

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Bibliographic Details
Published in:	American journal of physiology. Heart and circulatory physiology Vol. 304; no. 11; p. H1428
Main Authors:	Yaniv, Yael, Spurgeon, Harold A, Ziman, Bruce D, Lyashkov, Alexey E, Lakatta, Edward G
Format:	Journal Article
Language:	English
Published:	United States 01.06.2013
Subjects:	Adenosine Triphosphate - metabolism Animals Biological Clocks - physiology Calcium Signaling - physiology Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology Cell Separation Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - physiology Cytosol - metabolism Flavoproteins - metabolism Heart - physiology Heart Rate - physiology In Vitro Techniques Mitochondria, Heart - metabolism Mitochondria, Heart - physiology Myocardial Contraction - physiology Myocardium - cytology Myocardium - metabolism Myocytes, Cardiac - metabolism Myocytes, Cardiac - physiology Oxygen Consumption - physiology Phosphoprotein Phosphatases - antagonists & inhibitors Rabbits Receptors, Adrenergic, beta - physiology Respiratory Rate - physiology bioenergetics pacemaker automaticity calcium-activated adenylyl cyclase
ISSN:	1522-1539, 1522-1539
Online Access:	Get more information
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