RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting histone H2A and H2AX. RNF8 is the first ligase recruited to the damage site, and RNF168 follows RNF8-dependent ubiquitination. This suggests th...

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Bibliographic Details
Published in:	Cell Vol. 150; no. 6; p. 1182
Main Authors:	Mattiroli, Francesca, Vissers, Joseph H A, van Dijk, Willem J, Ikpa, Pauline, Citterio, Elisabetta, Vermeulen, Wim, Marteijn, Jurgen A, Sixma, Titia K
Format:	Journal Article
Language:	English
Published:	United States 14.09.2012
Subjects:	Amino Acid Sequence DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Histones - chemistry Histones - metabolism Humans Lysine - metabolism Models, Molecular Molecular Sequence Data Nucleosomes - chemistry Nucleosomes - metabolism Protein Structure, Tertiary Scattering, Small Angle Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism X-Ray Diffraction
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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