Neurobiological Correlates of Autism: A Review of Recent Research

This review paper integrates recent structural and functional imaging, postmortem, animal lesion, and neurochemical research about the pathophysiology of autism. An understanding of the neurobiological correlates of autism is becoming increasingly important as more children are diagnosed with the co...

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Vydané v:Child neuropsychology Ročník 12; číslo 1; s. 57 - 79
Hlavný autor: Penn, Helen E.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Taylor & Francis Group 01.02.2006
Predmet:
Autistic Disorder - physiopathology
Brain - abnormalities
Brain - metabolism
Cerebellum - abnormalities
Cerebellum - metabolism
Humans
Magnetic Resonance Imaging
Neurotransmitter Agents - metabolism
Positron-Emission Tomography
ISSN:0929-7049, 1744-4136
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Popis
Shrnutí:This review paper integrates recent structural and functional imaging, postmortem, animal lesion, and neurochemical research about the pathophysiology of autism. An understanding of the neurobiological correlates of autism is becoming increasingly important as more children are diagnosed with the condition and funding for well-targeted interventions increases. Converging evidence suggests that autism involves abnormalities in brain volume, neurotransmitter systems, and neuronal growth. In addition, evidence firmly links autism with abnormalities in the cerebellum, the medial temporal lobe, and the frontal lobe. Potential implications of these findings and suggestions for future research are reviewed.
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ISSN:0929-7049
1744-4136
DOI:10.1080/09297040500253546