Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system afflicting nearly three million individuals worldwide. Neuroimmune interactions between glial, neural, and immune cells play important roles in MS pathology and offer potential targets for therap...

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Vydáno v:Cell Ročník 186; číslo 7; s. 1309
Hlavní autoři: Charabati, Marc, Wheeler, Michael A, Weiner, Howard L, Quintana, Francisco J
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 30.03.2023
Témata:
Cell Physiological Phenomena
Central Nervous System
Humans
Inflammation - pathology
Multiple Sclerosis - drug therapy
Neuroglia
neuroimmunology
autoimmunity
multiple sclerosis
progressive MS
B cells
astrocytes
T cells
glia
microglia
ISSN:1097-4172, 1097-4172
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Popis
Shrnutí:Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system afflicting nearly three million individuals worldwide. Neuroimmune interactions between glial, neural, and immune cells play important roles in MS pathology and offer potential targets for therapeutic intervention. Here, we review underlying risk factors, mechanisms of MS pathogenesis, available disease modifying therapies, and examine the value of emerging technologies, which may address unmet clinical needs and identify novel therapeutic targets.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2023.03.008