Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants

This randomized trial of RSV F protein nanoparticle vaccination during pregnancy did not show efficacy (according to the prespecified success criterion) against RSV-associated, medically significant lower respiratory tract infection but suggested possible benefits with respect to other RSV-related o...

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Vydané v:The New England journal of medicine Ročník 383; číslo 5; s. 426 - 439
Hlavní autori: Madhi, Shabir A, Polack, Fernando P, Piedra, Pedro A, Munoz, Flor M, Trenholme, Adrian A, Simões, Eric A.F, Swamy, Geeta K, Agrawal, Sapeckshita, Ahmed, Khatija, August, Allison, Baqui, Abdullah H, Calvert, Anna, Chen, Janice, Cho, Iksung, Cotton, Mark F, Cutland, Clare L, Englund, Janet A, Fix, Amy, Gonik, Bernard, Hammitt, Laura, Heath, Paul T, de Jesus, Joanne N, Jones, Christine E, Khalil, Asma, Kimberlin, David W, Libster, Romina, Llapur, Conrado J, Lucero, Marilla, Pérez Marc, Gonzalo, Marshall, Helen S, Masenya, Masebole S, Martinón-Torres, Federico, Meece, Jennifer K, Nolan, Terry M, Osman, Ayman, Perrett, Kirsten P, Plested, Joyce S, Richmond, Peter C, Snape, Matthew D, Shakib, Julie H, Shinde, Vivek, Stoney, Tanya, Thomas, D. Nigel, Tita, Alan T, Varner, Michael W, Vatish, Manu, Vrbicky, Keith, Wen, Judy, Zaman, Khalequ, Zar, Heather J, Glenn, Gregory M, Fries, Louis F
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Boston Massachusetts Medical Society 30.07.2020
Predmet:
Age
Aluminum
Antibodies
F protein
Fusion protein
Gestation
Hospitalization
Hypotheses
Hypothesis testing
Hypoxemia
Infants
Infections
Nanoparticles
Objectives
Oxygen saturation
Pregnancy
Proteins
Respiratory diseases
Respiratory syncytial virus
Respiratory tract diseases
Sea level
Statistical analysis
Vaccination
Vaccine efficacy
Vaccines
Vitamin E
Womens health
ISSN:0028-4793, 1533-4406, 1533-4406
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Shrnutí:This randomized trial of RSV F protein nanoparticle vaccination during pregnancy did not show efficacy (according to the prespecified success criterion) against RSV-associated, medically significant lower respiratory tract infection but suggested possible benefits with respect to other RSV-related outcomes.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1908380