Framework for classifying chemicals for repeat dose toxicity using NAMs

EPAA’s ‘NAM Designathon 2023’ challenge for human toxicity sought to identify a classification system capable of categorising chemicals based on their bioactivity and bioavailability properties determined using non-animal methodologies (Worth et al. 2025). The proposal is made to classify chemicals...

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Veröffentlicht in:	Archives of toxicology Jg. 99; H. 8; S. 3223 - 3246
Hauptverfasser:	Doe, J. E., Botham, P., Holland, D., Gatnik, M. Fuart, Giri, V., Kang, H., Kalra, P., León Pérez, S., Marty, S., Moors, S., Raeburn, R., Reale, E., Settivari, R., Sica, M., Travis, K. Z., Wijeyesakere, S. J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2025
Schlagworte:	Animals Biological Availability Biomedical and Life Sciences Biomedicine Computer Simulation Dose-Response Relationship, Drug Environmental Health Hazardous Substances - classification Hazardous Substances - toxicity Humans Models, Biological Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Quantitative Structure-Activity Relationship Regulatory Toxicology Risk Assessment Toxicity Tests - methods Classification and labelling New approach methodology (NAM) Next-generation safety assessment Risk management Chemical safety assessment Regulatory toxicology
ISSN:	0340-5761, 1432-0738, 1432-0738
Online-Zugang:	Volltext
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