Terminal-Restriction Fragment Length Polymorphism (T-RFLP) Analysis for Changes in the Gut Microbiota Profiles of Indomethacin- and Rebamipide-Treated Mice

Background/Aims: We investigated the effects of indomethacin and rebamipide on the gut microbiota profiles using terminal restriction fragment polymorphism (T-RFLP) analysis. Materials and Methods: Female C57BL/6J mice were given indomethacin (10 mg/kg, s.c.) once a day and 2.5 mg rebamipide orally...

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Bibliographic Details
Published in:	Digestion Vol. 86; no. 3; pp. 250 - 257
Main Authors:	Imaeda, Hirotsugu, Fujimoto, Takehide, Takahashi, Kenichiro, Kasumi, Eiji, Fujiyama, Yoshihide, Andoh, Akira
Format:	Journal Article
Language:	English
Published:	Basel, Switzerland S. Karger AG 01.01.2012
Subjects:	Alanine - analogs & derivatives Alanine - toxicity Animals Bacteroides Cecum - drug effects Cecum - microbiology Cecum - pathology Clostridiaceae Disease Models, Animal DNA, Bacterial - genetics Drug Therapy, Combination Female Gastrointestinal Tract - drug effects Gastrointestinal Tract - microbiology Gastrointestinal Tract - pathology Ileum - drug effects Ileum - microbiology Ileum - pathology Indomethacin - toxicity Metagenome - genetics Mice Mice, Inbred C57BL Original Paper Polymorphism, Restriction Fragment Length Prevotella Quinolones - toxicity Nonsteroidal anti-inflammatory drugs Terminal-restriction fragment length polymorphism 16S ribosomal RNA BslI digestion
ISSN:	0012-2823, 1421-9867, 1421-9867
Online Access:	Get full text
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