Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage

CaV-channel dependent activation of BK channels is critical for feedback control of both calcium influx and cell excitability. Here we addressed the functional and spatial interaction between BK and CaV1.3 channels, unique CaV1 channels that activate at low voltages. We found that when BK and CaV1.3...

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Veröffentlicht in:	eLife Jg. 6
Hauptverfasser:	Vivas, Oscar, Moreno, Claudia M, Santana, Luis F, Hille, Bertil
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cambridge eLife Sciences Publications Ltd 30.06.2017 eLife Sciences Publications, Ltd
Schlagworte:	Biophysics and Structural Biology BK channels Calcium channels (voltage-gated) Calcium influx Channel gating Excitability ground-state depletion hippocampal neurons Hippocampus Hypotheses Immunoglobulins Localization Physiology Plasmids Potassium Potassium channels (calcium-gated) Software super-resolution microscopy Sympathetic nerves sympathetic neurons voltage-gated calcium channels
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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