Reduced expression of cyclooxygenase (COX) in idiopathic pulmonary fibrosis and sarcoidosis

Aims: To test the hypothesis that cyclooxygenase (COX)‐1 or COX‐2 expression is defective in lungs in idiopathic pulmonary fibrosis (IPF) and to characterize the cellular distribution. IPF is a progressive inflammatory lung disorder with an adverse prognosis. Previous work has shown that prostaglan...

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Bibliographic Details
Published in:	Histopathology Vol. 43; no. 4; pp. 381 - 386
Main Authors:	Petkova, D K, Clelland, C A, Ronan, J E, Lewis, S, Knox, A J
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01.10.2003 Blackwell
Subjects:	Adult Aged Biological and medical sciences Bronchi - enzymology Bronchi - pathology cyclooxygenase Cyclooxygenase 1 Cyclooxygenase 2 Female Fluorescent Antibody Technique, Indirect Humans idiopathic pulmonary fibrosis immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Isoenzymes - metabolism Macrophages, Alveolar - enzymology Macrophages, Alveolar - pathology Male Medical sciences Membrane Proteins Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pneumology Prostaglandin-Endoperoxide Synthases - metabolism Pulmonary Fibrosis - enzymology Pulmonary Fibrosis - pathology Respiratory Mucosa - enzymology Respiratory Mucosa - pathology Respiratory system : syndromes and miscellaneous diseases sarcoidosis Sarcoidosis, Pulmonary - enzymology Sarcoidosis, Pulmonary - pathology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Prostaglandin-endoperoxide synthase Anatomic pathology Pulmonary fibrosis Sarcoidosis Enzyme Systemic disease Idiopathic cyclooxygenase Oxidoreductases idiopathic pulmonary fibrosis immunohistochemistry
ISSN:	0309-0167, 1365-2559
Online Access:	Get full text
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