The role of MMP-2 and MMP-9 as prognostic markers in the early stages of tongue squamous cell carcinoma

Background Tongue cancer is the most common intra‐oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and metastasis. These processes require a controlled degradation of the extracellular matrix. Matrix Metalloproteinase‐2 (MMP‐2) and Matr...

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Vydáno v:	Journal of oral pathology & medicine Ročník 44; číslo 5; s. 345 - 352
Hlavní autoři:	Aparna, Manikkath, Rao, Lakshmi, Kunhikatta, Vijayanarayana, Radhakrishnan, Raghu
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Denmark Blackwell Publishing Ltd 01.05.2015
Témata:	Biomarkers, Tumor - biosynthesis Cohort Studies early stages Female Humans Immunohistochemistry Male Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis matrix metalloproteinases Middle Aged Neoplasm Metastasis Neoplasm Staging Prognosis Survival Rate tongue cancer Tongue Neoplasms - enzymology Tongue Neoplasms - pathology tongue cancer immunohistochemistry matrix metalloproteinases prognosis early stages
ISSN:	0904-2512, 1600-0714, 1600-0714
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Abstract	Background Tongue cancer is the most common intra‐oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and metastasis. These processes require a controlled degradation of the extracellular matrix. Matrix Metalloproteinase‐2 (MMP‐2) and Matrix Metalloproteinase‐9 (MMP‐9) are known to be important regulators of matrix lysis and play a significant role in the metastasis of malignancies. Aim and objectives To study the expression of MMP‐2 and MMP‐9 in the early stages of tongue squamous cell carcinoma and find the association between their expression and local recurrence, metastasis, and survival rates of the subjects. Materials and methods Fifty‐nine tumor biopsy samples of tongue squamous cell carcinoma in T1N0M0 and T2N0M0 stages were immunostained with MMP‐2 and MMP‐9 antibodies. The immunohistochemical expression was compared with the patient characteristics and outcome. Results Cytoplasmic expression of MMP‐2 correlated with that of MMP‐9 (r = 0.716, P < 0.001). Greater expression of MMP‐2 and MMP‐9 was observed in patients who subsequently developed local recurrence (P = 0.044 and P < 0.001, respectively), regional and/or distant metastasis (P < 0.001 and P = 0.001, respectively) of the tumor. Further, a higher expression of these biomarkers was associated with shorter survival. MMP‐9 was found to have better specificity for local recurrence, metastasis and survival. Conclusion Our results showed that these biomarkers may serve as indicators of a patient's risk potential for poor prognosis and presage the need for more aggressive treatment measures.
AbstractList	Background Tongue cancer is the most common intra‐oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and metastasis. These processes require a controlled degradation of the extracellular matrix. Matrix Metalloproteinase‐2 (MMP‐2) and Matrix Metalloproteinase‐9 (MMP‐9) are known to be important regulators of matrix lysis and play a significant role in the metastasis of malignancies. Aim and objectives To study the expression of MMP‐2 and MMP‐9 in the early stages of tongue squamous cell carcinoma and find the association between their expression and local recurrence, metastasis, and survival rates of the subjects. Materials and methods Fifty‐nine tumor biopsy samples of tongue squamous cell carcinoma in T1N0M0 and T2N0M0 stages were immunostained with MMP‐2 and MMP‐9 antibodies. The immunohistochemical expression was compared with the patient characteristics and outcome. Results Cytoplasmic expression of MMP‐2 correlated with that of MMP‐9 (r = 0.716, P < 0.001). Greater expression of MMP‐2 and MMP‐9 was observed in patients who subsequently developed local recurrence (P = 0.044 and P < 0.001, respectively), regional and/or distant metastasis (P < 0.001 and P = 0.001, respectively) of the tumor. Further, a higher expression of these biomarkers was associated with shorter survival. MMP‐9 was found to have better specificity for local recurrence, metastasis and survival. Conclusion Our results showed that these biomarkers may serve as indicators of a patient's risk potential for poor prognosis and presage the need for more aggressive treatment measures. Tongue cancer is the most common intra-oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and metastasis. These processes require a controlled degradation of the extracellular matrix. Matrix Metalloproteinase-2 (MMP-2) and Matrix Metalloproteinase-9 (MMP-9) are known to be important regulators of matrix lysis and play a significant role in the metastasis of malignancies.BACKGROUNDTongue cancer is the most common intra-oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and metastasis. These processes require a controlled degradation of the extracellular matrix. Matrix Metalloproteinase-2 (MMP-2) and Matrix Metalloproteinase-9 (MMP-9) are known to be important regulators of matrix lysis and play a significant role in the metastasis of malignancies.To study the expression of MMP-2 and MMP-9 in the early stages of tongue squamous cell carcinoma and find the association between their expression and local recurrence, metastasis, and survival rates of the subjects.AIM AND OBJECTIVESTo study the expression of MMP-2 and MMP-9 in the early stages of tongue squamous cell carcinoma and find the association between their expression and local recurrence, metastasis, and survival rates of the subjects.Fifty-nine tumor biopsy samples of tongue squamous cell carcinoma in T1 N0 M0 and T2 N0 M0 stages were immunostained with MMP-2 and MMP-9 antibodies. The immunohistochemical expression was compared with the patient characteristics and outcome.MATERIALS AND METHODSFifty-nine tumor biopsy samples of tongue squamous cell carcinoma in T1 N0 M0 and T2 N0 M0 stages were immunostained with MMP-2 and MMP-9 antibodies. The immunohistochemical expression was compared with the patient characteristics and outcome.Cytoplasmic expression of MMP-2 correlated with that of MMP-9 (r = 0.716, P < 0.001). Greater expression of MMP-2 and MMP-9 was observed in patients who subsequently developed local recurrence (P = 0.044 and P < 0.001, respectively), regional and/or distant metastasis (P < 0.001 and P = 0.001, respectively) of the tumor. Further, a higher expression of these biomarkers was associated with shorter survival. MMP-9 was found to have better specificity for local recurrence, metastasis and survival.RESULTSCytoplasmic expression of MMP-2 correlated with that of MMP-9 (r = 0.716, P < 0.001). Greater expression of MMP-2 and MMP-9 was observed in patients who subsequently developed local recurrence (P = 0.044 and P < 0.001, respectively), regional and/or distant metastasis (P < 0.001 and P = 0.001, respectively) of the tumor. Further, a higher expression of these biomarkers was associated with shorter survival. MMP-9 was found to have better specificity for local recurrence, metastasis and survival.Our results showed that these biomarkers may serve as indicators of a patient's risk potential for poor prognosis and presage the need for more aggressive treatment measures.CONCLUSIONOur results showed that these biomarkers may serve as indicators of a patient's risk potential for poor prognosis and presage the need for more aggressive treatment measures. Tongue cancer is the most common intra-oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and metastasis. These processes require a controlled degradation of the extracellular matrix. Matrix Metalloproteinase-2 (MMP-2) and Matrix Metalloproteinase-9 (MMP-9) are known to be important regulators of matrix lysis and play a significant role in the metastasis of malignancies. To study the expression of MMP-2 and MMP-9 in the early stages of tongue squamous cell carcinoma and find the association between their expression and local recurrence, metastasis, and survival rates of the subjects. Fifty-nine tumor biopsy samples of tongue squamous cell carcinoma in T1 N0 M0 and T2 N0 M0 stages were immunostained with MMP-2 and MMP-9 antibodies. The immunohistochemical expression was compared with the patient characteristics and outcome. Cytoplasmic expression of MMP-2 correlated with that of MMP-9 (r = 0.716, P < 0.001). Greater expression of MMP-2 and MMP-9 was observed in patients who subsequently developed local recurrence (P = 0.044 and P < 0.001, respectively), regional and/or distant metastasis (P < 0.001 and P = 0.001, respectively) of the tumor. Further, a higher expression of these biomarkers was associated with shorter survival. MMP-9 was found to have better specificity for local recurrence, metastasis and survival. Our results showed that these biomarkers may serve as indicators of a patient's risk potential for poor prognosis and presage the need for more aggressive treatment measures.
Author	Rao, Lakshmi Kunhikatta, Vijayanarayana Aparna, Manikkath Radhakrishnan, Raghu
Author_xml	– sequence: 1 givenname: Manikkath surname: Aparna fullname: Aparna, Manikkath organization: Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal University, Karnataka, Manipal, India – sequence: 2 givenname: Lakshmi surname: Rao fullname: Rao, Lakshmi organization: Department of Pathology, Kasturba Medical College, Manipal University, Karnataka, Manipal, India – sequence: 3 givenname: Vijayanarayana surname: Kunhikatta fullname: Kunhikatta, Vijayanarayana organization: Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, Manipal, India – sequence: 4 givenname: Raghu surname: Radhakrishnan fullname: Radhakrishnan, Raghu email: raghu.radhakrishnan@gmail.com organization: Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal University, Karnataka, Manipal, India
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Cites_doi	10.1016/S0003-9969(03)00172-9 10.1016/j.bbcan.2005.03.001 10.1158/1078-0432.CCR-0864-02 10.1016/S0021-9258(18)94267-5 10.1016/S1535-6108(02)00153-8 10.1053/hupa.2000.9756 10.1101/gad.13.1.35 10.1016/S0959-8049(00)00156-8 10.1002/1097-0215(20010120)95:1<44::AID-IJC1008>3.0.CO;2-M 10.1038/nrc745 10.1002/cncr.10916 10.1038/bjc.1998.372 10.1002/(SICI)1097-0347(199910)21:7<627::AID-HED7>3.0.CO;2-2 10.1016/j.archoralbio.2010.11.022 10.1038/35036374 10.1006/bbrc.1998.9128 10.1002/hed.20561 10.1016/j.oraloncology.2004.08.013 10.1111/j.1600-0714.2011.01110.x 10.1038/sj.onc.1205684 10.1016/j.oraloncology.2008.06.002 10.1007/s00432-004-0654-8 10.1093/ajcp/99.1.18 10.1034/j.1600-0714.2002.310202.x 10.1078/S0344-0338(04)70292-7 10.1023/A:1006749501682 10.1016/j.oraloncology.2004.01.006 10.1002/hed.20437 10.1126/science.277.5323.225 10.1177/00220345000790061001 10.1038/nature04186 10.2485/jhtb.15.54
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Keywords	tongue cancer immunohistochemistry matrix metalloproteinases prognosis early stages
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References	Sutinen M, Kainulainen T, Hurskainen T, et al. Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis. Br J Cancer 1998; 77: 2239-45. O-Charoenrat P, Rhys-Evans PH, Eccles SA. Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 2001; 127: 813-20. Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005; 438: 820-7. Franchi A, Santucci M, Masini M, Sardi I, Paglierani M, Gallo O. Expression of Matrix Metalloproteinase 1, Matrix Metalloproteinase 2, and Matrix Metalloproteinase 9 in carcinoma of the head and neck correlation with p53 status, inducible nitric oxide synthase activity, and angiogenesis. Cancer 2002; 95: 1902-10. Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 1997; 277: 225-8. Yu Q, Stamenkovic I. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev 1999; 1: 35-48. Lam EW, Hammad HM, Zwacka R, et al. Immunolocalization and adenoviral vector-mediated manganese superoxide dismutase gene transfer to experimental oral tumors. J Dent Res 2000; 79: 1410-7. Shimada T, Nakamura H, Yamashita K, et al. Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis. Clin Exp Metastasis 2000; 18: 179-88. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009; 45: 309-16. Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000; 2: 737-44. Katayama A, Bandoh N, Kishibe K, et al. Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis. Clin Cancer Res 2004; 10: 634-40. Fiore E, Fusco C, Romero P, Stamenkovic I. Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity. Oncogene 2002; 21: 5213-23. Yoshizaki T, Maruyama Y, Sato H, Furukawa M. Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma. Int J Cancer 2001; 95: 44-50. Curran S, Murray GI. Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis. Eur J Cancer 2000; 36: 1621-30. Barros SS, Henriques ÁC, Pereira KM, de Medeiros AM, Galvão HC, Freitas Rde A. Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip. Arch Oral Biol 2011; 56: 752-60. Guttman D, Stern Y, Shpitzer T, Ulanovski D, Druzd T, Feinmesser R. Expression of MMP-9, TIMP-1, CD-34 and factor-8 as prognostic markers for squamous cell carcinoma of the tongue. Oral Oncol 2004; 40: 798-803. Yorioka CW, Coletta RD, Alves F, Nishimoto IN, Kowalski LP, Graner E. Matrix metalloproteinase-2 and -9 activities correlate with the disease-free survival of oral squamous cell carcinoma patients. Int J Oncol 2002; 20: 189-94. Hiratsuka S, Nakamura K, Iwai S, et al. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2002; 2: 289-300. de Vicente JC, Fresno MF, Villalain L, Vega JA, Hernández Vallejo G. Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma. Oral Oncol 2005; 41: 283-93. Ondruschka C, Buhtz P, Motsch C, et al. Prognostic value of MMP-2, -9 and TIMP-1,-2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas. Pathol Res Pract 2002; 198: 509-15. Riedel F, Götte K, Schwalb J, Bergler W, Hörmann K. Expression of 92-kDa type IV collagenase correlates with angiogenic markers and poor survival in head and neck squamous cell carcinoma. Int J Oncol 2000; 17: 1099-105. Kusukawa J, Sasaguri Y, Shima I, Kameyama T, Morimatsu M. Expression of matrix metalloproteinase-2 related to lymph node metastasis of oral squamous cell carcinoma. A clinicopathological study. Am J Clin Pathol 1993; 99: 18-23. Kurahara S, Shinohara M, Ikebe T, et al. Expression of MMPS, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: correlations with tumor invasion and metastasis. Head Neck 1999; 21: 627-38. Fridman R, Toth M, Peña D, Mobashery S. Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). Cancer Res 1995; 55: 2548-55. Bindhu OS, Ramadas K, Sebastian P, Pillai MR. High expression levels of nuclear factor kappa B and gelatinases in the tumorigenesis of oral squamous cell carcinoma. Head Neck 2006; 28: 916-25. Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN. Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappa B. Cancer Res 2000; 60: 6557-62. Robinson CM, Stone AM, Shields JD, Huntley S, Paterson IC, Prime SS. Functional significance of MMP-2 and MMP-9 expression by human malignant oral keratinocyte cell lines. Arch Oral Biol 2003; 48: 779-86. Yang J, Lam EW, Hammad HM, Oberley TD, Oberley LW. Antioxidant enzyme levels in oral squamous cell carcinoma and normal human oral epithelium. J Oral Pathol Med 2002; 31: 71-7. Björklund M, Koivunen E. Gelatinase-mediated migration and invasion of cancer cells. Biochim Biophys Acta 2005; 1755: 37-69. Kato K, Hara A, Kuno T, et al. Matrix metalloproteinases 2 and 9 in oral squamous cell carcinomas: manifestation and localization of their activity. J Cancer Res Clin Oncol 2005; 131: 340-6. Overall CM, Wrana JL, Sodek J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem 1989; 264: 1860-9. Sobin LH, Witterkind CH. TNM classification of malignant tumors. New York: Wiley-Liss, 1997. Mäkinen LK, Häyry V, Atula T, et al. Prognostic significance of matrix metalloproteinase-2, -8, -9, and -13 in oral tongue cancer. J Oral Pathol Med 2012; 41: 394-9. Niu J, Gu X, Turton J, Meldrum C, Howard EW, Agrez M. Integrin-mediated signalling of gelatinase B secretion in colon cancer cells. Biochem Biophys Res Commun 1998; 249: 287-91. Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002; 2: 161-74. Hong Q, Jun T, Lei J, Xiling J, Tamamura R. Expression and clinical significance of matrix metalloproteinase-2 and its inhibitor TIMP-2 in oral squamous cell carcinoma. J Hard Tissue Biol 2006; 15: 54-60. Imanishi Y, Fujii M, Tokumaru Y, et al. Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma. Hum Pathol 2000; 31: 895-904. Patel BP, Shah SV, Shukla SN, Shah PM, Patel PS. Clinical significance of MMP-2 and MMP-9 in patients with oral cancer. Head Neck 2007; 29: 564-72. 2009; 45 2004; 40 2005; 131 2002; 31 2002; 198 2002; 95 1995; 55 1997; 277 2006; 15 1997 2005; 41 2002; 2 2005; 438 1999; 21 2000; 2 2011; 56 1999; 1 2005; 1755 2001; 127 2004; 10 2007; 29 2000; 18 2000; 17 2000; 36 2002; 20 2000; 79 1993; 99 2006; 28 2002; 21 1989; 264 2000; 31 2003; 48 2000; 60 1998; 249 2001; 95 1998; 77 2012; 41 e_1_2_5_27_1 e_1_2_5_28_1 e_1_2_5_25_1 e_1_2_5_26_1 e_1_2_5_24_1 e_1_2_5_21_1 e_1_2_5_22_1 Riedel F (e_1_2_5_39_1) 2000; 17 e_1_2_5_29_1 O‐Charoenrat P (e_1_2_5_30_1) 2001; 127 Yorioka CW (e_1_2_5_11_1) 2002; 20 e_1_2_5_20_1 e_1_2_5_15_1 e_1_2_5_38_1 e_1_2_5_14_1 e_1_2_5_17_1 e_1_2_5_36_1 e_1_2_5_9_1 e_1_2_5_16_1 e_1_2_5_37_1 e_1_2_5_8_1 e_1_2_5_34_1 e_1_2_5_7_1 e_1_2_5_10_1 e_1_2_5_35_1 e_1_2_5_6_1 e_1_2_5_13_1 e_1_2_5_32_1 e_1_2_5_5_1 e_1_2_5_12_1 e_1_2_5_33_1 e_1_2_5_3_1 e_1_2_5_2_1 Andela VB (e_1_2_5_19_1) 2000; 60 e_1_2_5_18_1 Sobin LH (e_1_2_5_4_1) 1997 e_1_2_5_31_1 Fridman R (e_1_2_5_23_1) 1995; 55
References_xml	– reference: Björklund M, Koivunen E. Gelatinase-mediated migration and invasion of cancer cells. Biochim Biophys Acta 2005; 1755: 37-69. – reference: O-Charoenrat P, Rhys-Evans PH, Eccles SA. Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 2001; 127: 813-20. – reference: Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009; 45: 309-16. – reference: Sobin LH, Witterkind CH. TNM classification of malignant tumors. New York: Wiley-Liss, 1997. – reference: Kurahara S, Shinohara M, Ikebe T, et al. Expression of MMPS, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: correlations with tumor invasion and metastasis. Head Neck 1999; 21: 627-38. – reference: Hong Q, Jun T, Lei J, Xiling J, Tamamura R. Expression and clinical significance of matrix metalloproteinase-2 and its inhibitor TIMP-2 in oral squamous cell carcinoma. J Hard Tissue Biol 2006; 15: 54-60. – reference: Shimada T, Nakamura H, Yamashita K, et al. Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis. Clin Exp Metastasis 2000; 18: 179-88. – reference: Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002; 2: 161-74. – reference: Niu J, Gu X, Turton J, Meldrum C, Howard EW, Agrez M. Integrin-mediated signalling of gelatinase B secretion in colon cancer cells. Biochem Biophys Res Commun 1998; 249: 287-91. – reference: Mäkinen LK, Häyry V, Atula T, et al. Prognostic significance of matrix metalloproteinase-2, -8, -9, and -13 in oral tongue cancer. J Oral Pathol Med 2012; 41: 394-9. – reference: Yorioka CW, Coletta RD, Alves F, Nishimoto IN, Kowalski LP, Graner E. Matrix metalloproteinase-2 and -9 activities correlate with the disease-free survival of oral squamous cell carcinoma patients. Int J Oncol 2002; 20: 189-94. – reference: Hiratsuka S, Nakamura K, Iwai S, et al. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2002; 2: 289-300. – reference: Franchi A, Santucci M, Masini M, Sardi I, Paglierani M, Gallo O. Expression of Matrix Metalloproteinase 1, Matrix Metalloproteinase 2, and Matrix Metalloproteinase 9 in carcinoma of the head and neck correlation with p53 status, inducible nitric oxide synthase activity, and angiogenesis. Cancer 2002; 95: 1902-10. – reference: Robinson CM, Stone AM, Shields JD, Huntley S, Paterson IC, Prime SS. Functional significance of MMP-2 and MMP-9 expression by human malignant oral keratinocyte cell lines. Arch Oral Biol 2003; 48: 779-86. – reference: Yoshizaki T, Maruyama Y, Sato H, Furukawa M. Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma. Int J Cancer 2001; 95: 44-50. – reference: Barros SS, Henriques ÁC, Pereira KM, de Medeiros AM, Galvão HC, Freitas Rde A. Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip. Arch Oral Biol 2011; 56: 752-60. – reference: Guttman D, Stern Y, Shpitzer T, Ulanovski D, Druzd T, Feinmesser R. Expression of MMP-9, TIMP-1, CD-34 and factor-8 as prognostic markers for squamous cell carcinoma of the tongue. Oral Oncol 2004; 40: 798-803. – reference: Curran S, Murray GI. Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis. Eur J Cancer 2000; 36: 1621-30. – reference: Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN. Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappa B. Cancer Res 2000; 60: 6557-62. – reference: de Vicente JC, Fresno MF, Villalain L, Vega JA, Hernández Vallejo G. Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma. Oral Oncol 2005; 41: 283-93. – reference: Imanishi Y, Fujii M, Tokumaru Y, et al. Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma. Hum Pathol 2000; 31: 895-904. – reference: Yu Q, Stamenkovic I. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev 1999; 1: 35-48. – reference: Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000; 2: 737-44. – reference: Overall CM, Wrana JL, Sodek J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem 1989; 264: 1860-9. – reference: Kusukawa J, Sasaguri Y, Shima I, Kameyama T, Morimatsu M. Expression of matrix metalloproteinase-2 related to lymph node metastasis of oral squamous cell carcinoma. A clinicopathological study. Am J Clin Pathol 1993; 99: 18-23. – reference: Patel BP, Shah SV, Shukla SN, Shah PM, Patel PS. Clinical significance of MMP-2 and MMP-9 in patients with oral cancer. Head Neck 2007; 29: 564-72. – reference: Katayama A, Bandoh N, Kishibe K, et al. Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis. Clin Cancer Res 2004; 10: 634-40. – reference: Fiore E, Fusco C, Romero P, Stamenkovic I. Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity. Oncogene 2002; 21: 5213-23. – reference: Fridman R, Toth M, Peña D, Mobashery S. Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). Cancer Res 1995; 55: 2548-55. – reference: Ondruschka C, Buhtz P, Motsch C, et al. Prognostic value of MMP-2, -9 and TIMP-1,-2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas. Pathol Res Pract 2002; 198: 509-15. – reference: Bindhu OS, Ramadas K, Sebastian P, Pillai MR. High expression levels of nuclear factor kappa B and gelatinases in the tumorigenesis of oral squamous cell carcinoma. Head Neck 2006; 28: 916-25. – reference: Yang J, Lam EW, Hammad HM, Oberley TD, Oberley LW. Antioxidant enzyme levels in oral squamous cell carcinoma and normal human oral epithelium. J Oral Pathol Med 2002; 31: 71-7. – reference: Riedel F, Götte K, Schwalb J, Bergler W, Hörmann K. Expression of 92-kDa type IV collagenase correlates with angiogenic markers and poor survival in head and neck squamous cell carcinoma. Int J Oncol 2000; 17: 1099-105. – reference: Sutinen M, Kainulainen T, Hurskainen T, et al. Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis. Br J Cancer 1998; 77: 2239-45. – reference: Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005; 438: 820-7. – reference: Kato K, Hara A, Kuno T, et al. Matrix metalloproteinases 2 and 9 in oral squamous cell carcinomas: manifestation and localization of their activity. J Cancer Res Clin Oncol 2005; 131: 340-6. – reference: Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 1997; 277: 225-8. – reference: Lam EW, Hammad HM, Zwacka R, et al. Immunolocalization and adenoviral vector-mediated manganese superoxide dismutase gene transfer to experimental oral tumors. J Dent Res 2000; 79: 1410-7. – volume: 29 start-page: 564 year: 2007 end-page: 72 article-title: Clinical significance of MMP‐2 and MMP‐9 in patients with oral cancer publication-title: Head Neck – volume: 17 start-page: 1099 year: 2000 end-page: 105 article-title: Expression of 92‐kDa type IV collagenase correlates with angiogenic markers and poor survival in head and neck squamous cell carcinoma publication-title: Int J Oncol – volume: 45 start-page: 309 year: 2009 end-page: 16 article-title: Global epidemiology of oral and oropharyngeal cancer publication-title: Oral Oncol – volume: 21 start-page: 627 year: 1999 end-page: 38 article-title: Expression of MMPS, MT‐MMP, and TIMPs in squamous cell carcinoma of the oral cavity: correlations with tumor invasion and metastasis publication-title: Head Neck – volume: 2 start-page: 161 year: 2002 end-page: 74 article-title: New functions for the matrix metalloproteinases in cancer progression publication-title: Nat Rev Cancer – volume: 1 start-page: 35 year: 1999 end-page: 48 article-title: Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44‐mediated tumor invasion publication-title: Genes Dev – volume: 20 start-page: 189 year: 2002 end-page: 94 article-title: Matrix metalloproteinase‐2 and ‐9 activities correlate with the disease‐free survival of oral squamous cell carcinoma patients publication-title: Int J Oncol – volume: 1755 start-page: 37 year: 2005 end-page: 69 article-title: Gelatinase‐mediated migration and invasion of cancer cells publication-title: Biochim Biophys Acta – volume: 10 start-page: 634 year: 2004 end-page: 40 article-title: Expressions of matrix metalloproteinases in early‐stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis publication-title: Clin Cancer Res – volume: 31 start-page: 895 year: 2000 end-page: 904 article-title: Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase‐2 in human head and neck squamous cell carcinoma publication-title: Hum Pathol – volume: 99 start-page: 18 year: 1993 end-page: 23 article-title: Expression of matrix metalloproteinase‐2 related to lymph node metastasis of oral squamous cell carcinoma. A clinicopathological study publication-title: Am J Clin Pathol – volume: 95 start-page: 44 year: 2001 end-page: 50 article-title: Expression of tissue inhibitor of matrix metalloproteinase‐2 correlates with activation of matrix metalloproteinase‐2 and predicts poor prognosis in tongue squamous cell carcinoma publication-title: Int J Cancer – volume: 79 start-page: 1410 year: 2000 end-page: 7 article-title: Immunolocalization and adenoviral vector‐mediated manganese superoxide dismutase gene transfer to experimental oral tumors publication-title: J Dent Res – volume: 21 start-page: 5213 year: 2002 end-page: 23 article-title: Matrix metalloproteinase 9 (MMP‐9/gelatinase B) proteolytically cleaves ICAM‐1 and participates in tumor cell resistance to natural killer cell‐mediated cytotoxicity publication-title: Oncogene – volume: 15 start-page: 54 year: 2006 end-page: 60 article-title: Expression and clinical significance of matrix metalloproteinase‐2 and its inhibitor TIMP‐2 in oral squamous cell carcinoma publication-title: J Hard Tissue Biol – volume: 277 start-page: 225 year: 1997 end-page: 8 article-title: Induction of cell migration by matrix metalloprotease‐2 cleavage of laminin‐5 publication-title: Science – volume: 48 start-page: 779 year: 2003 end-page: 86 article-title: Functional significance of MMP‐2 and MMP‐9 expression by human malignant oral keratinocyte cell lines publication-title: Arch Oral Biol – volume: 95 start-page: 1902 year: 2002 end-page: 10 article-title: Expression of Matrix Metalloproteinase 1, Matrix Metalloproteinase 2, and Matrix Metalloproteinase 9 in carcinoma of the head and neck correlation with p53 status, inducible nitric oxide synthase activity, and angiogenesis publication-title: Cancer – volume: 31 start-page: 71 year: 2002 end-page: 7 article-title: Antioxidant enzyme levels in oral squamous cell carcinoma and normal human oral epithelium publication-title: J Oral Pathol Med – volume: 131 start-page: 340 year: 2005 end-page: 6 article-title: Matrix metalloproteinases 2 and 9 in oral squamous cell carcinomas: manifestation and localization of their activity publication-title: J Cancer Res Clin Oncol – volume: 55 start-page: 2548 year: 1995 end-page: 55 article-title: Activation of progelatinase B (MMP‐9) by gelatinase A (MMP‐2) publication-title: Cancer Res – volume: 41 start-page: 394 year: 2012 end-page: 9 article-title: Prognostic significance of matrix metalloproteinase‐2, ‐8, ‐9, and ‐13 in oral tongue cancer publication-title: J Oral Pathol Med – volume: 18 start-page: 179 year: 2000 end-page: 88 article-title: Enhanced production and activation of progelatinase A mediated by membrane‐type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis publication-title: Clin Exp Metastasis – volume: 2 start-page: 737 year: 2000 end-page: 44 article-title: Matrix metalloproteinase‐9 triggers the angiogenic switch during carcinogenesis publication-title: Nat Cell Biol – volume: 60 start-page: 6557 year: 2000 end-page: 62 article-title: Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappa B publication-title: Cancer Res – volume: 28 start-page: 916 year: 2006 end-page: 25 article-title: High expression levels of nuclear factor kappa B and gelatinases in the tumorigenesis of oral squamous cell carcinoma publication-title: Head Neck – volume: 41 start-page: 283 year: 2005 end-page: 93 article-title: Expression and clinical significance of matrix metalloproteinase‐2 and matrix metalloproteinase‐9 in oral squamous cell carcinoma publication-title: Oral Oncol – volume: 77 start-page: 2239 year: 1998 end-page: 45 article-title: Expression of matrix metalloproteinases (MMP‐1 and ‐2) and their inhibitors (TIMP‐1, ‐2 and ‐3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis publication-title: Br J Cancer – volume: 198 start-page: 509 year: 2002 end-page: 15 article-title: Prognostic value of MMP‐2, ‐9 and TIMP‐1,‐2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas publication-title: Pathol Res Pract – year: 1997 – volume: 36 start-page: 1621 year: 2000 end-page: 30 article-title: Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis publication-title: Eur J Cancer – volume: 438 start-page: 820 year: 2005 end-page: 7 article-title: VEGFR1‐positive haematopoietic bone marrow progenitors initiate the pre‐metastatic niche publication-title: Nature – volume: 56 start-page: 752 year: 2011 end-page: 60 article-title: Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip publication-title: Arch Oral Biol – volume: 40 start-page: 798 year: 2004 end-page: 803 article-title: Expression of MMP‐9, TIMP‐1, CD‐34 and factor‐8 as prognostic markers for squamous cell carcinoma of the tongue publication-title: Oral Oncol – volume: 2 start-page: 289 year: 2002 end-page: 300 article-title: MMP9 induction by vascular endothelial growth factor receptor‐1 is involved in lung‐specific metastasis publication-title: Cancer Cell – volume: 127 start-page: 813 year: 2001 end-page: 20 article-title: Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck publication-title: Arch Otolaryngol Head Neck Surg – volume: 249 start-page: 287 year: 1998 end-page: 91 article-title: Integrin‐mediated signalling of gelatinase B secretion in colon cancer cells publication-title: Biochem Biophys Res Commun – volume: 264 start-page: 1860 year: 1989 end-page: 9 article-title: Independent regulation of collagenase, 72‐kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor‐beta publication-title: J Biol Chem – volume-title: TNM classification of malignant tumors year: 1997 ident: e_1_2_5_4_1 – volume: 127 start-page: 813 year: 2001 ident: e_1_2_5_30_1 article-title: Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck publication-title: Arch Otolaryngol Head Neck Surg – ident: e_1_2_5_34_1 doi: 10.1016/S0003-9969(03)00172-9 – ident: e_1_2_5_3_1 doi: 10.1016/j.bbcan.2005.03.001 – ident: e_1_2_5_7_1 doi: 10.1158/1078-0432.CCR-0864-02 – volume: 17 start-page: 1099 year: 2000 ident: e_1_2_5_39_1 article-title: Expression of 92‐kDa type IV collagenase correlates with angiogenic markers and poor survival in head and neck squamous cell carcinoma publication-title: Int J Oncol – ident: e_1_2_5_36_1 doi: 10.1016/S0021-9258(18)94267-5 – ident: e_1_2_5_38_1 doi: 10.1016/S1535-6108(02)00153-8 – ident: e_1_2_5_20_1 doi: 10.1053/hupa.2000.9756 – ident: e_1_2_5_26_1 doi: 10.1101/gad.13.1.35 – ident: e_1_2_5_24_1 doi: 10.1016/S0959-8049(00)00156-8 – ident: e_1_2_5_10_1 doi: 10.1002/1097-0215(20010120)95:1<44::AID-IJC1008>3.0.CO;2-M – ident: e_1_2_5_22_1 doi: 10.1038/nrc745 – ident: e_1_2_5_33_1 doi: 10.1002/cncr.10916 – ident: e_1_2_5_18_1 doi: 10.1038/bjc.1998.372 – volume: 20 start-page: 189 year: 2002 ident: e_1_2_5_11_1 article-title: Matrix metalloproteinase‐2 and ‐9 activities correlate with the disease‐free survival of oral squamous cell carcinoma patients publication-title: Int J Oncol – ident: e_1_2_5_8_1 doi: 10.1002/(SICI)1097-0347(199910)21:7<627::AID-HED7>3.0.CO;2-2 – volume: 60 start-page: 6557 year: 2000 ident: e_1_2_5_19_1 article-title: Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappa B publication-title: Cancer Res – ident: e_1_2_5_16_1 doi: 10.1016/j.archoralbio.2010.11.022 – ident: e_1_2_5_29_1 doi: 10.1038/35036374 – ident: e_1_2_5_27_1 doi: 10.1006/bbrc.1998.9128 – ident: e_1_2_5_15_1 doi: 10.1002/hed.20561 – ident: e_1_2_5_13_1 doi: 10.1016/j.oraloncology.2004.08.013 – ident: e_1_2_5_17_1 doi: 10.1111/j.1600-0714.2011.01110.x – ident: e_1_2_5_28_1 doi: 10.1038/sj.onc.1205684 – ident: e_1_2_5_2_1 doi: 10.1016/j.oraloncology.2008.06.002 – ident: e_1_2_5_12_1 doi: 10.1007/s00432-004-0654-8 – ident: e_1_2_5_31_1 doi: 10.1093/ajcp/99.1.18 – ident: e_1_2_5_6_1 doi: 10.1034/j.1600-0714.2002.310202.x – ident: e_1_2_5_21_1 doi: 10.1078/S0344-0338(04)70292-7 – ident: e_1_2_5_9_1 doi: 10.1023/A:1006749501682 – volume: 55 start-page: 2548 year: 1995 ident: e_1_2_5_23_1 article-title: Activation of progelatinase B (MMP‐9) by gelatinase A (MMP‐2) publication-title: Cancer Res – ident: e_1_2_5_35_1 doi: 10.1016/j.oraloncology.2004.01.006 – ident: e_1_2_5_14_1 doi: 10.1002/hed.20437 – ident: e_1_2_5_25_1 doi: 10.1126/science.277.5323.225 – ident: e_1_2_5_5_1 doi: 10.1177/00220345000790061001 – ident: e_1_2_5_37_1 doi: 10.1038/nature04186 – ident: e_1_2_5_32_1 doi: 10.2485/jhtb.15.54
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Snippet	Background Tongue cancer is the most common intra‐oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor... Tongue cancer is the most common intra-oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and...
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SubjectTerms	Biomarkers, Tumor - biosynthesis Cohort Studies early stages Female Humans Immunohistochemistry Male Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis matrix metalloproteinases Middle Aged Neoplasm Metastasis Neoplasm Staging Prognosis Survival Rate tongue cancer Tongue Neoplasms - enzymology Tongue Neoplasms - pathology
Title	The role of MMP-2 and MMP-9 as prognostic markers in the early stages of tongue squamous cell carcinoma
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