Review article: role of oxidative stress in the progression of non‐alcoholic steatosis

Summary The mechanisms responsible for the progression of nonalcoholic fatty liver disease (NAFLD) to more severe liver injury are still poorly understood. Data from animal models suggest that oxidative stress contributes to steatohepatitis and an increase of lipid peroxidation has been documented i...

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Vydáno v:Alimentary pharmacology & therapeutics Ročník 22; číslo s2; s. 71 - 73
Hlavní autoři: ALBANO, E., MOTTARAN, E., OCCHINO, G., REALE, E., VIDALI, M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.11.2005
Témata:
Antibodies - blood
Disease Progression
Fatty Liver - complications
Fatty Liver - immunology
Fatty Liver - metabolism
Humans
Lipid Peroxidation - immunology
Lipid Peroxidation - physiology
Liver Cirrhosis - etiology
Liver Cirrhosis - metabolism
Oxidative Stress - physiology
ISSN:0269-2813, 1365-2036
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Shrnutí:Summary The mechanisms responsible for the progression of nonalcoholic fatty liver disease (NAFLD) to more severe liver injury are still poorly understood. Data from animal models suggest that oxidative stress contributes to steatohepatitis and an increase of lipid peroxidation has been documented in human NAFLD. By measuring the titers of circulating antibodies against lipid peroxidation products as markers of oxidative stress we have observed that NAFLD patients have titers of these antibodies significantly higher than in controls. Moreover, the titers of lipid peroxidation‐related antibodies are associated with a 3‐fold increase in the risk of developing advanced fibrosis/cirrhosis. Although the mechanisms causing oxidative stress in NAFLD have not been elucidated, these results support the involvement of lipid peroxidation in the processes leading to liver fibrosis associated with NAFLD.
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ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2005.02601.x