Retention in Plaque and Remineralization of Enamel Lesions by Various Forms of Calcium in a Mouthrinse or Sugar-free Chewing Gum

Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) nanocomplexes incorporated into sugar-free chewing gum have been shown to remineralize enamel subsurface lesions in situ. The aim of this study was to compare the ability of CPP-ACP, with that of other forms of calcium, to be retained in su...

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Veröffentlicht in:Journal of dental research Jg. 82; H. 3; S. 206 - 211
Hauptverfasser: Reynolds, E.C., Cai, F., Shen, P., Walker, G.D.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States SAGE Publications 01.03.2003
SAGE PUBLICATIONS, INC
Schlagworte:
Analysis of Variance
Calcium - pharmacokinetics
Calcium Phosphates - pharmacokinetics
Caseins - pharmacokinetics
Chewing Gum
Cross-Over Studies
Dental Enamel - metabolism
Dental Plaque - drug therapy
Dental Plaque - metabolism
Double-Blind Method
Humans
Immunoenzyme Techniques
Mouthwashes - chemistry
Mouthwashes - therapeutic use
Tooth Demineralization - drug therapy
Tooth Remineralization - methods
incorporation
dental plaque
casein phosphopeptide-amorphous calcium phosphate
enamel remineralization
sugar-free chewing gum
mouthrinse
ISSN:0022-0345, 1544-0591
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Zusammenfassung:Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) nanocomplexes incorporated into sugar-free chewing gum have been shown to remineralize enamel subsurface lesions in situ. The aim of this study was to compare the ability of CPP-ACP, with that of other forms of calcium, to be retained in supragingival plaque and remineralize enamel subsurface lesions in situ when delivered in a mouthrinse or sugar-free gum in randomized, double-blind trials. In the mouthrinse study, only the CPP-ACP-containing mouthrinse significantly increased plaque calcium and inorganic phosphate levels, and the CPP were immunolocalized to the surfaces of bacterial cells as well as the intercellular matrix. In the chewing gum studies, the gum containing the CPP-ACP, although not containing the most calcium per piece of gum, produced the highest level of enamel remineralization independent of gum-chewing frequency and duration. The CPP could be detected in plaque extracts 3 hrs after subjects chewed the CPP-ACP-containing gum. The results showed that CPP-ACP were superior to other forms of calcium in remineralizing enamel subsurface lesions.
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ISSN:0022-0345
1544-0591
DOI:10.1177/154405910308200311