ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease. Primary tauopathies are characterized by pathological tau accumulation and neuronal and synaptic loss. Apolipoprotein E (ApoE)-mediated neuroinflammation is involved in the progression of tau-mediated neurodegeneration, and em...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 379; no. 6628; p. eadd1236
Main Authors:	Seo, Dong-Oh, O'Donnell, David, Jain, Nimansha, Ulrich, Jason D, Herz, Jasmin, Li, Yuhao, Lemieux, Mackenzie, Cheng, Jiye, Hu, Hao, Serrano, Javier R, Bao, Xin, Franke, Emily, Karlsson, Maria, Meier, Martin, Deng, Su, Desai, Chandani, Dodiya, Hemraj, Lelwala-Guruge, Janaki, Handley, Scott A, Kipnis, Jonathan, Sisodia, Sangram S, Gordon, Jeffrey I, Holtzman, David M
Format:	Journal Article
Language:	English
Published:	United States 13.01.2023
Subjects:	Animals Anti-Bacterial Agents - pharmacology Apolipoproteins E - genetics Apolipoproteins E - metabolism Disease Models, Animal Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - physiology Humans Mice Mice, Transgenic Neuroinflammatory Diseases - genetics Neuroinflammatory Diseases - metabolism Neuroinflammatory Diseases - microbiology Sex Factors tau Proteins - genetics tau Proteins - metabolism Tauopathies - genetics Tauopathies - metabolism Tauopathies - microbiology
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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