Impact of body mass index on survival after colorectal cancer diagnosis: the Cancer Prevention Study-II Nutrition Cohort

The impact of body mass index (BMI) on survival after colorectal cancer diagnosis is poorly understood. This study assessed the association of pre- and postdiagnosis BMI with all-cause and cause-specific survival among men and women diagnosed with colorectal cancer in a prospective cohort. Participa...

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Bibliographic Details
Published in:Journal of clinical oncology Vol. 30; no. 1; p. 42
Main Authors: Campbell, Peter T, Newton, Christina C, Dehal, Ahmed N, Jacobs, Eric J, Patel, Alpa V, Gapstur, Susan M
Format: Journal Article
Language:English
Published: United States 01.01.2012
Subjects:
Adult
Aged
Aged, 80 and over
Body Mass Index
Cohort Studies
Colorectal Neoplasms - complications
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - mortality
Female
Humans
Male
Middle Aged
Obesity - complications
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Risk Factors
Self Report
Surveys and Questionnaires
Survival Analysis
Survival Rate
United States - epidemiology
United States
ISSN:1527-7755, 1527-7755
Online Access:Get more information
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Summary:The impact of body mass index (BMI) on survival after colorectal cancer diagnosis is poorly understood. This study assessed the association of pre- and postdiagnosis BMI with all-cause and cause-specific survival among men and women diagnosed with colorectal cancer in a prospective cohort. Participants in the Cancer Prevention Study-II Nutrition Cohort reported weight and other risk factor information via a self-administered questionnaire at baseline in 1992 to 1993. Updated information on current weight and incident cancer was reported via periodic follow-up questionnaires. This analysis includes 2,303 cohort participants who were diagnosed with nonmetastatic colorectal cancer between baseline and mid 2007 and were observed for mortality from diagnosis through December 2008. A total of 851 participants with colorectal cancer died during the 16-year follow-up period, including 380 as a result of colorectal cancer and 153 as a result of cardiovascular disease (CVD). In analyses of prediagnosis BMI (weight reported at baseline in 1992 to 1993; mean, 7 years before colorectal cancer diagnosis), obese BMI (≥ 30 kg/m(2)) relative to normal BMI (18.5 to 24.9 kg/m(2)) was associated with higher risk of mortality resulting from all causes (relative risk [RR], 1.30; 95% CI, 1.06 to 1.58), colorectal cancer (RR, 1.35; 95% CI, 1.01 to 1.80), and CVD (RR, 1.68; 95% CI, 1.07 to 2.65). Postdiagnosis BMI (based on weight reported; mean, 1.5 years after diagnosis) was not associated with all-cause or cause-specific mortality. This study suggests that prediagnosis BMI, but not postdiagnosis BMI, is an important predictor of survival among patients with nonmetastatic colorectal cancer.
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ISSN:1527-7755
1527-7755
DOI:10.1200/JCO.2011.38.0287