Bacterial c-di-GMP is an immunostimulatory molecule

Cyclic diguanylate (c-di-GMP) is a bacterial intracellular signaling molecule. We have shown that treatment with exogenous c-di-GMP inhibits Staphylococcus aureus infection in a mouse model. We now report that c-di-GMP is an immodulator and immunostimulatory molecule. Intramammary treatment of mice...

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Bibliographic Details
Published in:	Journal of Immunology Vol. 178; no. 4; pp. 2171 - 2181
Main Authors:	Karaolis, David K R, Means, Terry K, Yang, De, Takahashi, Munehisa, Yoshimura, Teizo, Muraille, Eric, Philpott, Dana, Schroeder, John T, Hyodo, Mamoru, Hayakawa, Yoshihiro, Talbot, Brian G, Brouillette, Eric, Malouin, François
Format:	Journal Article
Language:	English
Published:	United States 15.02.2007
Subjects:	Adjuvants, Immunologic - pharmacology Animals Antibodies, Bacterial - immunology Antibody Formation - drug effects Antibody Formation - immunology Antigens, CD - immunology Bacterial Proteins - immunology Cells, Cultured Coagulase - immunology Coagulase - pharmacology Cyclic GMP - analogs & derivatives Cyclic GMP - immunology Cyclic GMP - pharmacology Cytokines - immunology Dendritic Cells - immunology Disease Models, Animal Extracellular Signal-Regulated MAP Kinases - immunology Female Granulocytes - immunology Humans Macrophage Activation - drug effects MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology Mice Monocytes - immunology p38 Mitogen-Activated Protein Kinases - immunology Receptors, Chemokine - immunology Staphylococcal Infections - immunology Staphylococcal Infections - prevention & control Staphylococcus aureus Staphylococcus aureus - immunology Vaccination
ISSN:	0022-1767, 1365-2567
Online Access:	Get full text
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