Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is known about the phenotypic and genetic links of heart-brain systems. We quantified heart-brain connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) Vol. 380; no. 6648; p. abn6598
Main Authors: Zhao, Bingxin, Li, Tengfei, Fan, Zirui, Yang, Yue, Shu, Juan, Yang, Xiaochen, Wang, Xifeng, Luo, Tianyou, Tang, Jiarui, Xiong, Di, Wu, Zhenyi, Li, Bingxuan, Chen, Jie, Shan, Yue, Tomlinson, Chalmer, Zhu, Ziliang, Li, Yun, Stein, Jason L, Zhu, Hongtu
Format: Journal Article
Language:English
Published: United States 02.06.2023
Subjects:
Brain - diagnostic imaging
Brain - pathology
Brain Diseases - genetics
Cardiovascular Diseases - genetics
Genetic Loci
Genetic Predisposition to Disease
Gray Matter - diagnostic imaging
Heart - diagnostic imaging
Humans
Magnetic Resonance Imaging
White Matter - diagnostic imaging
ISSN:1095-9203, 1095-9203
Online Access:Get more information
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Summary:Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is known about the phenotypic and genetic links of heart-brain systems. We quantified heart-brain connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI traits displayed numerous association patterns with brain gray matter morphometry, white matter microstructure, and functional networks. We identified 80 associated genomic loci ( < 6.09 × 10 ) for heart MRI traits, which shared genetic influences with cardiovascular and brain diseases. Genetic correlations were observed between heart MRI traits and brain-related traits and disorders. Mendelian randomization suggests that heart conditions may causally contribute to brain disorders. Our results advance a multiorgan perspective on human health by revealing heart-brain connections and shared genetic influences.
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.abn6598