Prevalence and prognostic value of PD-L1 expression and tumor mutational burden in persistent, recurrent, or metastatic cervical cancer

To evaluate the prevalence and prognostic role of programmed death ligand 1 (PD-L1) expression and tumor mutational burden (TMB) in patients with non-immunotherapy-treated advanced cervical cancer. Clinical data were retrospectively collected from medical records between January 1, 2008, and Decembe...

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Published in:Journal of gynecologic oncology Vol. 35; no. 6; pp. e105 - 11
Main Authors: Baek, Min-Hyun, Chen, Lei, Tekin, Cumhur, Cristescu, Razvan, Jin, Xiao Yang, Shao, Changxia, Ihm, Soo Yeon, Jelinic, Petar, Park, Jeong-Yeol
Format: Journal Article
Language:English
Published: Korea (South) Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology 01.11.2024
대한부인종양학회
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adult
Aged
B7-H1 Antigen - genetics
B7-H1 Antigen - metabolism
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Carcinoma, Adenosquamous - genetics
Carcinoma, Adenosquamous - mortality
Carcinoma, Adenosquamous - pathology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Female
Humans
Middle Aged
Mutation
Neoplasm Recurrence, Local - epidemiology
Neoplasm Recurrence, Local - genetics
Original
Prevalence
Prognosis
Retrospective Studies
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - pathology
산부인과학
Cervical Cancer
PD-L1 Protein
ISSN:2005-0380, 2005-0399, 2005-0399
Online Access:Get full text
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Summary:To evaluate the prevalence and prognostic role of programmed death ligand 1 (PD-L1) expression and tumor mutational burden (TMB) in patients with non-immunotherapy-treated advanced cervical cancer. Clinical data were retrospectively collected from medical records between January 1, 2008, and December 31, 2016, at Asan Medical Center (Korea); archived tumor samples were assessed for PD-L1 expression (combined positive score [CPS] ≥1) and TMB (≥175 mutations/exome). Overall survival (OS) was defined as time from advanced diagnosis or initiation of first-line or second-line systemic therapy until death/last follow-up. The association of OS with PD-L1 expression and TMB were analyzed using the log-rank test and Cox proportional hazards model adjusted for covariates. Of 267 patients, 76.0% had squamous cell carcinoma (SCC), 24.0% had adenocarcinoma (AC)/adenosquamous carcinoma (ASC), 64.4% had PD-L1 CPS ≥1, and 32.6% had TMB ≥175 mutations/exome. PD-L1 CPS ≥1 and TMB ≥175 mutations/exome were more prevalent in SCC than in AC/ASC (73.9% and 37.2% vs. 34.4% and 17.7%). There was no association between OS and PD-L1 expression (CPS ≥1 vs. <1: adjusted hazard ratio [HR]=1.14; 95% confidence interval [CI]=0.84-1.53 from advanced diagnosis); OS trended shorter for the subgroup with TMB ≥175 versus <175 mutations/exome (adjusted HR=1.29; 95% CI=0.95-1.75). Retrospective analysis of non-immunotherapy-treated patients with advanced cervical cancer demonstrated a higher prevalence of PD-L1 CPS ≥1 and TMB ≥175 mutations/exome in SCC versus AC/ASC. PD-L1 CPS ≥1 was not associated with OS; TMB ≥175 mutations/exome showed a trend toward shorter OS. Additional studies are needed to confirm these findings.
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Current affiliation: Department of Obstetrics and Gynecology, School of Medicine, Kangwon National University, Chuncheon, Korea
https://doi.org/10.3802/jgo.2024.35.e105
ISSN:2005-0380
2005-0399
2005-0399
DOI:10.3802/jgo.2024.35.e105