Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon?

Introduction: Drug-induced liver injury (DILI) represents a serious medical challenge and a potentially fatal adverse event. Currently, DILI is a diagnosis of exclusion, and whilst the electronic evaluation of serious drug-induced hepatotoxicity (eDISH) have revolutionised the early assessment of DI...

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Bibliographic Details
Published in:	Expert opinion on drug safety Vol. 15; no. 5; pp. 625 - 634
Main Authors:	Clarke, Joanna I., Dear, James W., Antoine, Daniel J.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 03.05.2016
Subjects:	Acetaminophen Acetaminophen - adverse effects Biomarkers - metabolism Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - therapy DILI Drug-Related Side Effects and Adverse Reactions - diagnosis Drug-Related Side Effects and Adverse Reactions - physiopathology Humans idiosyncratic Prognosis qualification Sensitivity and Specificity qualification DILI Acetaminophen idiosyncratic
ISSN:	1474-0338, 1744-764X, 1744-764X
Online Access:	Get full text
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