Detection of an early HIV-1 infection by HIV RNA testing in an Italian blood donor during the preseroconversion window period

BACKGROUND: The implementation of NAT technologies for HIV screening has further reduced the diagnostic window in recent HIV infection. There is still a debate regarding the cost effectiveness of genomic screening of blood donations for transfusion‐transmitted viruses (HBV, HCV, HIV). STUDY DESIGN A...

Full description

Saved in:
Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Vol. 43; no. 7; pp. 848 - 852
Main Authors: Aprili, Giuseppe, Gandini, Giorgio, Piccoli, Pierluigi, Bressan, Fausto, Gironcoli, Marzia De, Mazzi, Romualdo, Parisi, Saverio G., Gessoni, Gianluca, Marchiori, Giorgio, Franchini, Massimo
Format: Journal Article
Language:English
Published: Oxford, UK and Malden, USA Blackwell Science Inc 01.07.2003
Blackwell Publishing
Subjects:
Acquired Immunodeficiency Syndrome - diagnosis
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - virology
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antiretroviral Therapy, Highly Active
Biological and medical sciences
Blood Donors
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
HIV Core Protein p24 - blood
HIV Seropositivity - virology
HIV-1 - genetics
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
RNA, Viral - blood
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Human
Immunopathology
Retroviridae
Male
AIDS
Serology
Medical screening
Immune deficiency
Lentivirus
Transfusion safety
Blood
Infection
Virus
Case study
Donor
Viral disease
Early
Human immunodeficiency virus
ISSN:0041-1132, 1537-2995
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND: The implementation of NAT technologies for HIV screening has further reduced the diagnostic window in recent HIV infection. There is still a debate regarding the cost effectiveness of genomic screening of blood donations for transfusion‐transmitted viruses (HBV, HCV, HIV). STUDY DESIGN AND METHODS: Since October 2001, at the Transfusion Service of Verona, single‐donation NAT testing for HCV and HIV‐1 (Procleix TMA HIV‐1/HCV Assay) of all blood donations has been performed. CASE REPORT: A case of acute HIV‐1 infection detected by HIV NAT in a repeat blood donor who donated during the preseroconversion window period is reported. All blood components donated were discarded, and the donor started antiretroviral therapy 2 weeks after blood donation. HIV‐1 p24 antigen was still negative 10 days after the HIV‐1 RNA‐positive blood donation. Seroconversion was documented by Day 41 after donation. CONCLUSION: This case report testifies that HIV NAT screening of blood donation is effective in preventing the transmission of HIV infection through blood components.
Bibliography:ark:/67375/WNG-N1C6V5RQ-4
istex:C79C40F6D70D75450BD29986674BA1CCAB827C32
ArticleID:TRF423
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0041-1132
1537-2995
DOI:10.1046/j.1537-2995.2003.00423.x