Effect of CYP2C9-VKORC1 interaction on warfarin stable dosage and its predictive algorithm

This study aimed to identify the effect of CYP2C9–VKORC1 interaction on warfarin dosage requirement and its predictive algorithm by investigating four populations. Generalized linear model was used to evaluate the relationship between the interaction and warfarin stable dosage (WSD), whereas multipl...

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Veröffentlicht in:	Journal of clinical pharmacology Jg. 55; H. 3; S. 251 - 257
Hauptverfasser:	Li, Xi, Liu, Rong, Yan, Han, Tang, Jie, Yin, Ji-Ye, Mao, Xiao-Yuan, Yang, Fang, Luo, Zhi-Yin, Tan, Sheng-Lan, He, Hui, Chen, Xiao-Ping, Liu, Zhao-Qian, Li, Zhi, Zhou, Hong-Hao, Zhang, Wei
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Blackwell Publishing Ltd 01.03.2015 American College of Clinical Pharmacology Wiley Subscription Services, Inc
Schlagworte:	Adolescent Adult African Continental Ancestry Group - genetics Aged Aged, 80 and over Algorithms Anticoagulants - administration & dosage Anticoagulants - adverse effects Anticoagulants - pharmacokinetics Asian Continental Ancestry Group - genetics Blood Coagulation - drug effects Chi-Square Distribution Child Cytochrome P-450 CYP2C9 - genetics Cytochrome P-450 CYP2C9 - metabolism Drug Dosage Calculations Drug Monitoring - methods epistasis European Continental Ancestry Group - genetics Female Gene Frequency Genotype Health risk assessment Humans International Normalized Ratio Linear Models Male Middle Aged Models, Biological Pharmacogenetics Phenotype racial difference Regression analysis Risk Factors single nucleotide polymorphism Vitamin K Epoxide Reductases - genetics Vitamin K Epoxide Reductases - metabolism warfarin Warfarin - administration & dosage Warfarin - adverse effects Warfarin - pharmacokinetics Young Adult racial difference algorithms epistasis single nucleotide polymorphism warfarin
ISSN:	0091-2700, 1552-4604, 1552-4604
Online-Zugang:	Volltext
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