Topical application of highly concentrated water-in-oil emulsions: Physiological skin parameters and skin penetration in vivo - A pilot study

Important aspects in the development of new dermal drug delivery systems are the formulations' physicochemical properties and stability. Moreover, their influence on skin physiology and their penetration performance in vivo are of crucial interest. We have recently developed novel concentrated...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 571; p. 118694
Main Authors:	Binder, Lisa, Klang, Victoria, Sheikh Rezaei, Safoura, Neuer, Olivia, Zhang, Ziwei, Lunter, Dominique Jasmin, Wolzt, Michael, Valenta, Claudia
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 25.11.2019
Subjects:	Administration, Cutaneous Adult Confocal Raman spectroscopy Drug Delivery Systems - methods Emulsifying Agents - chemistry Emulsions Fluorescein - administration & dosage Fluorescein - pharmacokinetics Fluorescein sodium Fluorescent Dyes - administration & dosage Fluorescent Dyes - pharmacokinetics Healthy Volunteers Humans Oils - chemistry Permeability Pilot Projects Silicone surfactant Silicones - chemistry Skin - drug effects Skin - metabolism Tape stripping Water - chemistry Water Loss, Insensible - drug effects Water-in-oil emulsion Young Adult SC Silicone surfactant TEWL Water-in-oil emulsion CRS W/O Tape stripping Fluorescein sodium Confocal Raman spectroscopy API
ISSN:	0378-5173, 1873-3476, 1873-3476
Online Access:	Get full text
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