Topical application of highly concentrated water-in-oil emulsions: Physiological skin parameters and skin penetration in vivo - A pilot study

Important aspects in the development of new dermal drug delivery systems are the formulations' physicochemical properties and stability. Moreover, their influence on skin physiology and their penetration performance in vivo are of crucial interest. We have recently developed novel concentrated...

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Veröffentlicht in:	International journal of pharmaceutics Jg. 571; S. 118694
Hauptverfasser:	Binder, Lisa, Klang, Victoria, Sheikh Rezaei, Safoura, Neuer, Olivia, Zhang, Ziwei, Lunter, Dominique Jasmin, Wolzt, Michael, Valenta, Claudia
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 25.11.2019
Schlagworte:	Administration, Cutaneous Adult Confocal Raman spectroscopy Drug Delivery Systems - methods Emulsifying Agents - chemistry Emulsions Fluorescein - administration & dosage Fluorescein - pharmacokinetics Fluorescein sodium Fluorescent Dyes - administration & dosage Fluorescent Dyes - pharmacokinetics Healthy Volunteers Humans Oils - chemistry Permeability Pilot Projects Silicone surfactant Silicones - chemistry Skin - drug effects Skin - metabolism Tape stripping Water - chemistry Water Loss, Insensible - drug effects Water-in-oil emulsion Young Adult SC Silicone surfactant TEWL Water-in-oil emulsion CRS W/O Tape stripping Fluorescein sodium Confocal Raman spectroscopy API
ISSN:	0378-5173, 1873-3476, 1873-3476
Online-Zugang:	Volltext
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