Topical application of highly concentrated water-in-oil emulsions: Physiological skin parameters and skin penetration in vivo - A pilot study

Important aspects in the development of new dermal drug delivery systems are the formulations' physicochemical properties and stability. Moreover, their influence on skin physiology and their penetration performance in vivo are of crucial interest. We have recently developed novel concentrated...

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Veröffentlicht in:International journal of pharmaceutics Jg. 571; S. 118694
Hauptverfasser: Binder, Lisa, Klang, Victoria, Sheikh Rezaei, Safoura, Neuer, Olivia, Zhang, Ziwei, Lunter, Dominique Jasmin, Wolzt, Michael, Valenta, Claudia
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 25.11.2019
Schlagworte:
Administration, Cutaneous
Adult
Confocal Raman spectroscopy
Drug Delivery Systems - methods
Emulsifying Agents - chemistry
Emulsions
Fluorescein - administration & dosage
Fluorescein - pharmacokinetics
Fluorescein sodium
Fluorescent Dyes - administration & dosage
Fluorescent Dyes - pharmacokinetics
Healthy Volunteers
Humans
Oils - chemistry
Permeability
Pilot Projects
Silicone surfactant
Silicones - chemistry
Skin - drug effects
Skin - metabolism
Tape stripping
Water - chemistry
Water Loss, Insensible - drug effects
Water-in-oil emulsion
Young Adult
SC
Silicone surfactant
TEWL
Water-in-oil emulsion
CRS
W/O
Tape stripping
Fluorescein sodium
Confocal Raman spectroscopy
API
ISSN:0378-5173, 1873-3476, 1873-3476
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Zusammenfassung:Important aspects in the development of new dermal drug delivery systems are the formulations' physicochemical properties and stability. Moreover, their influence on skin physiology and their penetration performance in vivo are of crucial interest. We have recently developed novel concentrated water-in-oil emulsions based on a non-ionic silicone surfactant; the present study deals with the effect of these formulations on physiological skin parameters of healthy volunteers after repeated application. Variations in skin condition and barrier integrity were investigated using classical biophysical and spectroscopic techniques. After four weeks of continuous treatment, no signs of skin irritation could be observed. Both tested emulsions had a positive effect on skin properties despite their relatively high water content and low lipid content. In vivo tape stripping studies revealed penetrated amounts of the incorporated model drug fluorescein sodium of almost 50% of the applied dose, with a superior performance of emulsions with isopropyl myristate when compared to liquid paraffin. In summary, our study confirmed the suitability of the developed W/O emulsions for pharmaceutic and cosmetic applications. [Display omitted]
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0378-5173
1873-3476
1873-3476
DOI:10.1016/j.ijpharm.2019.118694