The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis
The AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status switch regulating several systems including glucose and lipid metabolism. Recently, AMPK has been implicated in the control of skeletal muscle mass by decreasing mTORC1 activi...
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| Vydáno v: | American Journal of Physiology: Cell Physiology Ročník 303; číslo 5; s. C475 |
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| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
01.09.2012
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| ISSN: | 1522-1563, 1522-1563 |
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| Abstract | The AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status switch regulating several systems including glucose and lipid metabolism. Recently, AMPK has been implicated in the control of skeletal muscle mass by decreasing mTORC1 activity and increasing protein degradation through regulation of ubiquitin-proteasome and autophagy pathways. In this review, we give an overview of the central role of AMPK in the control of skeletal muscle plasticity. We detail particularly its implication in the control of the hypertrophic and atrophic signaling pathways. In the light of these cumulative and attractive results, AMPK appears as a key player in regulating muscle homeostasis and the modulation of its activity may constitute a therapeutic potential in treating muscle wasting syndromes in humans. |
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| AbstractList | The AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status switch regulating several systems including glucose and lipid metabolism. Recently, AMPK has been implicated in the control of skeletal muscle mass by decreasing mTORC1 activity and increasing protein degradation through regulation of ubiquitin-proteasome and autophagy pathways. In this review, we give an overview of the central role of AMPK in the control of skeletal muscle plasticity. We detail particularly its implication in the control of the hypertrophic and atrophic signaling pathways. In the light of these cumulative and attractive results, AMPK appears as a key player in regulating muscle homeostasis and the modulation of its activity may constitute a therapeutic potential in treating muscle wasting syndromes in humans. The AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status switch regulating several systems including glucose and lipid metabolism. Recently, AMPK has been implicated in the control of skeletal muscle mass by decreasing mTORC1 activity and increasing protein degradation through regulation of ubiquitin-proteasome and autophagy pathways. In this review, we give an overview of the central role of AMPK in the control of skeletal muscle plasticity. We detail particularly its implication in the control of the hypertrophic and atrophic signaling pathways. In the light of these cumulative and attractive results, AMPK appears as a key player in regulating muscle homeostasis and the modulation of its activity may constitute a therapeutic potential in treating muscle wasting syndromes in humans.The AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status switch regulating several systems including glucose and lipid metabolism. Recently, AMPK has been implicated in the control of skeletal muscle mass by decreasing mTORC1 activity and increasing protein degradation through regulation of ubiquitin-proteasome and autophagy pathways. In this review, we give an overview of the central role of AMPK in the control of skeletal muscle plasticity. We detail particularly its implication in the control of the hypertrophic and atrophic signaling pathways. In the light of these cumulative and attractive results, AMPK appears as a key player in regulating muscle homeostasis and the modulation of its activity may constitute a therapeutic potential in treating muscle wasting syndromes in humans. |
| Author | Csibi, Alfredo Bernardi, Henri Pagano, Allan F Sanchez, Anthony M J Raibon, Audrey Candau, Robin B |
| Author_xml | – sequence: 1 givenname: Anthony M J surname: Sanchez fullname: Sanchez, Anthony M J email: anthony.sanchez@univ-montp1.fr organization: INRA, UMR866 Dynamique Musculaire Et Métabolisme, 2 Place Viala, 34060 Montpellier, France. anthony.sanchez@univ-montp1.fr – sequence: 2 givenname: Robin B surname: Candau fullname: Candau, Robin B – sequence: 3 givenname: Alfredo surname: Csibi fullname: Csibi, Alfredo – sequence: 4 givenname: Allan F surname: Pagano fullname: Pagano, Allan F – sequence: 5 givenname: Audrey surname: Raibon fullname: Raibon, Audrey – sequence: 6 givenname: Henri surname: Bernardi fullname: Bernardi, Henri |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22700795$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Energy Metabolism - physiology Gene Expression Regulation, Enzymologic - physiology Humans Muscle, Skeletal - enzymology Muscle, Skeletal - metabolism |
| Title | The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis |
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