Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control

PD-1 is a key negative regulator of CD8 + T cell activation and is highly expressed by exhausted T cells in cancer and chronic viral infection. Although PD-1 blockade can improve viral and tumor control, physiological PD-1 expression prevents immunopathology and improves memory formation. The mechan...

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Bibliographic Details
Published in:	Nature immunology Vol. 25; no. 10; pp. 1871 - 1883
Main Authors:	Weiss, Sarah A., Huang, Amy Y., Fung, Megan E., Martinez, Daniela, Chen, Alex C. Y., LaSalle, Thomas J., Miller, Brian C., Scharer, Christopher D., Hegde, Mudra, Nguyen, Thao H., Rowe, Jared H., Osborn, Jossef F., Patterson, Dillon G., Sifnugel, Natalia, Mei-An Nolan, C., Davidson, Richard A., Schwartz, Marc A., Bally, Alexander P. R., Neeld, Dennis K., LaFleur, Martin W., Boss, Jeremy M., Doench, John G., Nicholas Haining, W., Sharpe, Arlene H., Sen, Debattama R.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.10.2024 Nature Publishing Group
Subjects:	631/250/1619/554/1834 631/250/2502/2170 631/250/255/2514 631/337/100/102 Animals Biomedical and Life Sciences Biomedicine CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell activation Chronic infection Clonal deletion Enhancer Elements, Genetic - genetics Epigenesis, Genetic Epigenetics Immunological memory Immunology Infections Infectious Diseases Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - virology Memory cells Mice Mice, Inbred C57BL Mice, Knockout PD-1 protein Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Viral infections
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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