A Machine-Learning-Based Method to Detect Degradation of Motor Control Stability with Implications to Diagnosis of Presymptomatic Parkinson’s Disease: A Simulation Study

Background and aim: Parkinson’s disease (PD), a neuro-degenerative disorder, is often detected by the onset of its motor symptoms such as rest tremor. Unfortunately, motor symptoms appear only when approximately 40–60% of the dopaminergic neurons in the substantia nigra are lost. In most cases, by t...

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