Endothelial dysfunction in middle-aged and older men with low testosterone is associated with elevated circulating endothelin-1

Low testosterone in middle-aged/older men contributes to accelerated vascular aging, including endothelial dysfunction. However, the mechanisms by which low testosterone affects endothelial dysfunction are not well understood. We sought to determine whether higher endothelin-1 (ET-1) levels are asso...

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Bibliographic Details
Published in:	American journal of physiology. Regulatory, integrative and comparative physiology Vol. 328; no. 3; p. R253
Main Authors:	Babcock, Matthew C, DuBose, Lyndsey E, Hildreth, Kerry L, Stauffer, Brian L, Kohrt, Wendy M, Wenner, Megan M, Moreau, Kerrie L
Format:	Journal Article
Language:	English
Published:	United States 01.03.2025
Subjects:	Adult Age Factors Aged Aging - blood Biomarkers - blood Brachial Artery - diagnostic imaging Brachial Artery - metabolism Brachial Artery - physiopathology Endothelin-1 - blood Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Humans Male Middle Aged Testosterone - blood Testosterone - deficiency Vasodilation - physiology flow-mediated dilation aging testosterone endothelin-1
ISSN:	1522-1490, 1522-1490
Online Access:	Get more information
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