Line-Field Confocal Optical Coherence Tomography of Plaque Psoriasis Under IL-17 Inhibitor Therapy: Artificial Intelligence-Supported Analysis

To date, therapeutic responses in plaque psoriasis are evaluated with clinical scores. No objective examination has been established. A recently developed non-invasive imaging tool, line-field confocal optical coherence tomography (LC-OCT), enables the in vivo live imaging of skin changes in psorias...

Full description

Saved in:
Bibliographic Details
Published in:Applied sciences Vol. 15; no. 2; p. 535
Main Authors: Wirsching, Hanna B., Mayer, Oliver J., Schlingmann, Sophia, Thamm, Janis R., Schiele, Stefan, Rubeck, Anna, Heinz, Wera, Welzel, Julia, Schuh, Sandra
Format: Journal Article
Language:English
Published: Basel MDPI AG 01.01.2025
Subjects:
AI model
Arthritis
Artificial intelligence
Care and treatment
Dermatologic agents
Dermatology
Drug therapy
Erythema
Formulae, receipts, prescriptions
Health aspects
Imaging systems
LC-OCT
line-field confocal optical coherence tomography
Medical research
Medicine, Experimental
Microscopy
Psoriasis
Skin
Steroids
therapeutic monitoring
Tomography
Visualization
Germany
France
Paris France
ISSN:2076-3417, 2076-3417
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To date, therapeutic responses in plaque psoriasis are evaluated with clinical scores. No objective examination has been established. A recently developed non-invasive imaging tool, line-field confocal optical coherence tomography (LC-OCT), enables the in vivo live imaging of skin changes in psoriasis under therapy. The aim of this study was to measure therapeutic response clinically and with LC-OCT, comparing the subjectively scored epidermal changes with an AI-supported analysis. This prospective, observational study included 12 patients with psoriasis starting a systemic treatment with IL-17 inhibitors (secukinumab, ixekizumab, and bimekizumab). LC-OCT and clinical assessment with a local psoriasis and severity index of the study plaque and a control area were performed before the initiation of therapy as well as after 4 and 12 weeks of treatment. A manual and AI-supported measurement of the thickness of epidermis, stratum corneum, and undulation of the dermo-epidermal junction was carried out. Acanthosis and hyperkeratosis showed a significant reduction under treatment. AI-supported calculations were compared to subjective measurements showing good reliability with high correlation. AI-supported analysis of vascular changes may serve as a prognostic and therapeutic response marker in the future.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:2076-3417
2076-3417
DOI:10.3390/app15020535