Line-Field Confocal Optical Coherence Tomography of Plaque Psoriasis Under IL-17 Inhibitor Therapy: Artificial Intelligence-Supported Analysis

To date, therapeutic responses in plaque psoriasis are evaluated with clinical scores. No objective examination has been established. A recently developed non-invasive imaging tool, line-field confocal optical coherence tomography (LC-OCT), enables the in vivo live imaging of skin changes in psorias...

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Vydané v:Applied sciences Ročník 15; číslo 2; s. 535
Hlavní autori: Wirsching, Hanna B., Mayer, Oliver J., Schlingmann, Sophia, Thamm, Janis R., Schiele, Stefan, Rubeck, Anna, Heinz, Wera, Welzel, Julia, Schuh, Sandra
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Basel MDPI AG 01.01.2025
Predmet:
AI model
Arthritis
Artificial intelligence
Care and treatment
Dermatologic agents
Dermatology
Drug therapy
Erythema
Formulae, receipts, prescriptions
Health aspects
Imaging systems
LC-OCT
line-field confocal optical coherence tomography
Medical research
Medicine, Experimental
Microscopy
Psoriasis
Skin
Steroids
therapeutic monitoring
Tomography
Visualization
Germany
France
Paris France
ISSN:2076-3417, 2076-3417
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Abstract To date, therapeutic responses in plaque psoriasis are evaluated with clinical scores. No objective examination has been established. A recently developed non-invasive imaging tool, line-field confocal optical coherence tomography (LC-OCT), enables the in vivo live imaging of skin changes in psoriasis under therapy. The aim of this study was to measure therapeutic response clinically and with LC-OCT, comparing the subjectively scored epidermal changes with an AI-supported analysis. This prospective, observational study included 12 patients with psoriasis starting a systemic treatment with IL-17 inhibitors (secukinumab, ixekizumab, and bimekizumab). LC-OCT and clinical assessment with a local psoriasis and severity index of the study plaque and a control area were performed before the initiation of therapy as well as after 4 and 12 weeks of treatment. A manual and AI-supported measurement of the thickness of epidermis, stratum corneum, and undulation of the dermo-epidermal junction was carried out. Acanthosis and hyperkeratosis showed a significant reduction under treatment. AI-supported calculations were compared to subjective measurements showing good reliability with high correlation. AI-supported analysis of vascular changes may serve as a prognostic and therapeutic response marker in the future.
AbstractList To date, therapeutic responses in plaque psoriasis are evaluated with clinical scores. No objective examination has been established. A recently developed non-invasive imaging tool, line-field confocal optical coherence tomography (LC-OCT), enables the in vivo live imaging of skin changes in psoriasis under therapy. The aim of this study was to measure therapeutic response clinically and with LC-OCT, comparing the subjectively scored epidermal changes with an AI-supported analysis. This prospective, observational study included 12 patients with psoriasis starting a systemic treatment with IL-17 inhibitors (secukinumab, ixekizumab, and bimekizumab). LC-OCT and clinical assessment with a local psoriasis and severity index of the study plaque and a control area were performed before the initiation of therapy as well as after 4 and 12 weeks of treatment. A manual and AI-supported measurement of the thickness of epidermis, stratum corneum, and undulation of the dermo-epidermal junction was carried out. Acanthosis and hyperkeratosis showed a significant reduction under treatment. AI-supported calculations were compared to subjective measurements showing good reliability with high correlation. AI-supported analysis of vascular changes may serve as a prognostic and therapeutic response marker in the future.
Audience Academic
Author Heinz, Wera
Rubeck, Anna
Wirsching, Hanna B.
Schlingmann, Sophia
Schiele, Stefan
Thamm, Janis R.
Mayer, Oliver J.
Welzel, Julia
Schuh, Sandra
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Snippet To date, therapeutic responses in plaque psoriasis are evaluated with clinical scores. No objective examination has been established. A recently developed...
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SubjectTerms AI model
Arthritis
Artificial intelligence
Care and treatment
Dermatologic agents
Dermatology
Drug therapy
Erythema
Formulae, receipts, prescriptions
Health aspects
Imaging systems
LC-OCT
line-field confocal optical coherence tomography
Medical research
Medicine, Experimental
Microscopy
Psoriasis
Skin
Steroids
therapeutic monitoring
Tomography
Visualization
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Title Line-Field Confocal Optical Coherence Tomography of Plaque Psoriasis Under IL-17 Inhibitor Therapy: Artificial Intelligence-Supported Analysis
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Volume 15
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