Developing drugs in cancer-related bone pain
•About 75% of patients with bone involvement is interested by pain.•Cancer-related bone pain has both a nociceptive and a neuropathic component.•Cancer-related bone pain could be treated with analgesics drugs, or prevented with “bone therapy”.•Moreover, new biological drugs are in development for th...
Uložené v:
| Vydané v: | Critical reviews in oncology/hematology Ročník 119; s. 66 - 74 |
|---|---|
| Hlavní autori: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Netherlands
Elsevier B.V
01.11.2017
|
| Predmet: | |
| ISSN: | 1040-8428, 1879-0461, 1879-0461 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | •About 75% of patients with bone involvement is interested by pain.•Cancer-related bone pain has both a nociceptive and a neuropathic component.•Cancer-related bone pain could be treated with analgesics drugs, or prevented with “bone therapy”.•Moreover, new biological drugs are in development for this topic.
Cancer-related bone pain is a frequent and important key problem for metastatic patients that may reduce quality of life, with related limitations in daily activities and morbidity. Often traditional approach to pain may fail given the complex pathophysiology of this phenomenon.
The aim of this review is to describe promising therapies for cancer-related bone pain, from the pathophysiology to the clinical trials currently ongoing. Moreover, any new evidence for better approach to cancer-related bone pain with the traditional drugs is also considered.
In clinical practice opioids remain the most important pharmacologic treatment for severe pain related to bone cancer. Regard developing drugs, anti-NGF and anti-TrkA are the most investigated new drug in this setting, but a future role in clinical practice is still uncertain. |
|---|---|
| AbstractList | •About 75% of patients with bone involvement is interested by pain.•Cancer-related bone pain has both a nociceptive and a neuropathic component.•Cancer-related bone pain could be treated with analgesics drugs, or prevented with “bone therapy”.•Moreover, new biological drugs are in development for this topic.
Cancer-related bone pain is a frequent and important key problem for metastatic patients that may reduce quality of life, with related limitations in daily activities and morbidity. Often traditional approach to pain may fail given the complex pathophysiology of this phenomenon.
The aim of this review is to describe promising therapies for cancer-related bone pain, from the pathophysiology to the clinical trials currently ongoing. Moreover, any new evidence for better approach to cancer-related bone pain with the traditional drugs is also considered.
In clinical practice opioids remain the most important pharmacologic treatment for severe pain related to bone cancer. Regard developing drugs, anti-NGF and anti-TrkA are the most investigated new drug in this setting, but a future role in clinical practice is still uncertain. Cancer-related bone pain is a frequent and important key problem for metastatic patients that may reduce quality of life, with related limitations in daily activities and morbidity. Often traditional approach to pain may fail given the complex pathophysiology of this phenomenon. The aim of this review is to describe promising therapies for cancer-related bone pain, from the pathophysiology to the clinical trials currently ongoing. Moreover, any new evidence for better approach to cancer-related bone pain with the traditional drugs is also considered. In clinical practice opioids remain the most important pharmacologic treatment for severe pain related to bone cancer. Regard developing drugs, anti-NGF and anti-TrkA are the most investigated new drug in this setting, but a future role in clinical practice is still uncertain. Cancer-related bone pain is a frequent and important key problem for metastatic patients that may reduce quality of life, with related limitations in daily activities and morbidity. Often traditional approach to pain may fail given the complex pathophysiology of this phenomenon.INTRODUCTIONCancer-related bone pain is a frequent and important key problem for metastatic patients that may reduce quality of life, with related limitations in daily activities and morbidity. Often traditional approach to pain may fail given the complex pathophysiology of this phenomenon.The aim of this review is to describe promising therapies for cancer-related bone pain, from the pathophysiology to the clinical trials currently ongoing. Moreover, any new evidence for better approach to cancer-related bone pain with the traditional drugs is also considered.METHODSThe aim of this review is to describe promising therapies for cancer-related bone pain, from the pathophysiology to the clinical trials currently ongoing. Moreover, any new evidence for better approach to cancer-related bone pain with the traditional drugs is also considered.In clinical practice opioids remain the most important pharmacologic treatment for severe pain related to bone cancer. Regard developing drugs, anti-NGF and anti-TrkA are the most investigated new drug in this setting, but a future role in clinical practice is still uncertain.CONCLUSIONSIn clinical practice opioids remain the most important pharmacologic treatment for severe pain related to bone cancer. Regard developing drugs, anti-NGF and anti-TrkA are the most investigated new drug in this setting, but a future role in clinical practice is still uncertain. |
| Author | Ripamonti, Carla Ida Santini, Daniele Antonuzzo, Andrea Lucchesi, Maurizio Rozzi, Antonio Sardi, Iacopo Lanzetta, Gaetano Armento, Grazia Favre, Claudio |
| Author_xml | – sequence: 1 givenname: Maurizio surname: Lucchesi fullname: Lucchesi, Maurizio email: mauriziolucchesi84@gmail.com organization: Thoracic Cancer Centre, Pulmonology Unit, University Hospital of Pisa, Pisa, Italy – sequence: 2 givenname: Gaetano surname: Lanzetta fullname: Lanzetta, Gaetano email: g_lanzetta58@hotmail.com organization: Medical Oncology Unit, IRCCS Neuromed, Pozzilli, Italy – sequence: 3 givenname: Andrea surname: Antonuzzo fullname: Antonuzzo, Andrea email: andrea.antonuzzo@tin.it organization: Medical Oncology Unit 1 SSN, Pisa University Hospital, Pisa, Italy – sequence: 4 givenname: Antonio surname: Rozzi fullname: Rozzi, Antonio email: antoniorozzi@virgilio.it organization: Medical Oncology Unit, Italian Neuro-Traumatology Institute, Grottaferrata, Italy – sequence: 5 givenname: Iacopo surname: Sardi fullname: Sardi, Iacopo email: iacopo.sardi@meyer.it organization: Department of Pediatric Oncology and Hematology, Anna Meyer Children’s University Hospital, Florence, Italy – sequence: 6 givenname: Claudio surname: Favre fullname: Favre, Claudio email: claudio.favre@meyer.it organization: Department of Pediatric Oncology and Hematology, Anna Meyer Children’s University Hospital, Florence, Italy – sequence: 7 givenname: Carla Ida surname: Ripamonti fullname: Ripamonti, Carla Ida email: carla.ripamonti@istitutotumori.mi.it organization: Supportive Care in Cancer Unit, IRCCS National Cancer Institute, Milan, Italy – sequence: 8 givenname: Daniele surname: Santini fullname: Santini, Daniele email: D.Santini@unicampus.it organization: Medical Oncology Unit, Campus Biomedico University Hospital, Rome, Italy – sequence: 9 givenname: Grazia surname: Armento fullname: Armento, Grazia email: G.Armento@unicampus.it organization: Medical Oncology Unit, Campus Biomedico University Hospital, Rome, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28893462$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkMlOwzAQQC0EYv8FlCMHEsaJ4-WC2BepEhc4W44zRi6pU-y0Uv-eoLJInHryHN68kd8B2Q59QEIyCgUFys-nhY1-iLjsgy1KoKIAWQDUW2SfSqFyYJxujzMwyCUr5R45SGkKAIxxsUv2SilVxXi5T85ucYldP_fhLWvj4i1lPmTWBIsxj9iZAdusGY9nc-PDEdlxpkt4_P0ektf7u5ebx3zy_PB0czXJLavokHPFGt5UxomaCy4UGKesU7R0DdrWoTMCuOKcWsGkNKx1LbXY8ArqRrgaq0NyuvbOY_-xwDTomU8Wu84E7BdJU1VJqlhN6YiefKOLZoatnkc_M3Glf344AnIN2NinFNH9IhT0V0w91X8x9VdMDVKPMcfVi3-r1g9m8H0YovHdJoLrtQDHWEuPUSfrcWzb-oh20G3vN5Fc_pPYzgdvTfeOq80Un7AZrTI |
| CitedBy_id | crossref_primary_10_1177_10225536241266671 crossref_primary_10_1016_j_dcmed_2025_03_006 crossref_primary_10_1016_j_phrs_2018_07_019 crossref_primary_10_3389_fonc_2023_1156618 crossref_primary_10_1111_jphp_13064 crossref_primary_10_1016_j_amsu_2020_10_070 crossref_primary_10_3390_cells11213375 crossref_primary_10_1016_j_pathol_2020_08_009 crossref_primary_10_3390_brainsci13040644 crossref_primary_10_1007_s12264_023_01126_6 crossref_primary_10_62116_PNJ_2024_50_4_167 crossref_primary_10_1155_2022_1459636 crossref_primary_10_3389_fncel_2018_00038 crossref_primary_10_12998_wjcc_v7_i13_1554 |
| Cites_doi | 10.1038/nm0895-774 10.1093/brain/awq194 10.1200/JCO.2013.54.3926 10.1073/pnas.0611253104 10.1016/S0090-4295(01)01597-7 10.1016/j.jpainsymman.2014.05.021 10.1016/j.jhsa.2009.10.030 10.1007/s00520-013-1932-2 10.1186/ar2716 10.1056/NEJM199612123352401 10.1016/j.nurt.2009.07.009 10.1046/j.1526-4637.2000.00047.x 10.1111/cns.12487 10.1093/bja/aen088 10.1016/j.tips.2005.12.001 10.1085/jgp.200609576 10.1097/00003643-199705001-00003 10.1038/nrd4612 10.1002/cncr.27789 10.1038/nrc2618 10.1002/art.1780350315 10.1016/S0304-3959(00)00370-5 10.1093/jnci/94.19.1458 10.1093/emboj/cdg254 10.1093/annonc/mdi122 10.1097/00001756-200305060-00018 10.1016/S0304-3959(02)00102-1 10.4049/jimmunol.168.12.6412 10.1097/j.pain.0000000000000211 10.1046/j.1464-410X.1997.00097.x 10.1523/JNEUROSCI.3188-06.2006 10.1016/j.pbb.2005.07.016 10.1002/(SICI)1521-1878(199810)20:10<837::AID-BIES9>3.0.CO;2-D 10.1016/S0140-6736(10)62344-6 10.1002/jor.21170 10.1177/1933719111410711 10.1002/art.34385 10.1186/1744-8069-6-87 10.1146/annurev.physiol.68.040204.100431 10.1016/j.ejca.2004.03.025 10.1016/0304-3959(90)90004-W 10.1016/j.mcn.2009.02.009 10.1111/pme.12299 10.1016/S0306-4522(02)00165-3 10.1016/S8756-3282(99)00215-X 10.1200/JCO.2013.51.7219 10.1016/S1470-2045(12)70040-2 10.1016/j.bone.2010.09.019 10.1016/S1526-5900(03)00636-9 10.1111/jnc.12093 10.1016/j.conb.2004.05.003 10.1097/00001756-199805110-00038 10.1016/j.pneurobio.2005.10.006 10.1002/aja.1001260308 10.3816/SCT.2007.n.016 10.1111/j.1464-410X.2010.09716.x 10.1523/JNEUROSCI.0249-05.2005 10.1016/j.joca.2014.10.003 10.1200/JCO.2003.05.147 10.1038/sj.bjc.6602551 10.1097/SPC.0000000000000048 10.1158/1078-0432.CCR-06-0931 10.1016/S0079-6123(00)29030-4 10.1016/j.pain.2011.07.020 10.1016/S0022-3565(24)38269-2 10.1002/jor.20986 10.1016/j.neuroscience.2010.08.056 10.1021/cn9000186 10.1016/j.pain.2007.06.006 10.3389/fphys.2016.00157 10.1200/JCO.1999.17.3.846 10.1016/j.suponc.2010.12.004 10.1016/S0896-6273(02)00908-X 10.1200/JCO.2010.29.7101 10.1093/annonc/mdg367 10.1016/0304-3959(95)00017-M 10.1097/01.ajp.0000210902.67849.e6 10.1111/j.1460-9568.2012.08235.x 10.1097/j.pain.0000000000000610 10.1155/2012/758181 10.1200/JCO.2010.31.3304 10.1023/A:1022475432077 10.1038/368246a0 10.1038/nrc747 10.17925/EOH.2012.08.3.148 10.1038/nrn1914 10.1016/S1474-4422(03)00557-X 10.1023/A:1012506426440 10.1016/0092-8674(91)90419-Y 10.1016/j.bone.2009.09.013 10.1016/j.pbb.2004.07.011 10.1016/j.pbb.2007.03.017 10.1093/annonc/mdm056 10.1097/00003086-200004000-00013 10.1002/cne.22160 10.1016/8756-3282(95)00425-4 10.1016/j.clinbiochem.2009.06.017 10.1016/S0959-4388(02)00326-4 10.1038/35082088 10.1038/35093019 10.1177/0269216311428528 10.1016/j.neuron.2004.12.015 10.1111/j.1464-410X.2009.08851.x 10.1200/JCO.1998.16.6.2038 |
| ContentType | Journal Article |
| Copyright | 2017 Elsevier B.V. Copyright © 2017 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2017 Elsevier B.V. – notice: Copyright © 2017 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.critrevonc.2017.08.005 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1879-0461 |
| EndPage | 74 |
| ExternalDocumentID | 28893462 10_1016_j_critrevonc_2017_08_005 S1040842817302202 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29F 4.4 457 4CK 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABJNI ABLJU ABMAC ABMZM ABWVN ABXDB ACDAQ ACGFS ACIEU ACIUM ACLOT ACRLP ACRPL ACVFH ADCNI ADEZE ADMUD ADNMO AEBSH AEIPS AEKER AENEX AEUPX AEVXI AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGHFR AGQPQ AGUBO AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP AXJTR BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HED HMK HMO HVGLF HZ~ IHE J1W KOM M29 M41 MO0 N9A O-L O9- OAUVE OC~ OO- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SEL SES SEW SSH SSZ T5K UDS W2D WUQ Z5R ~G- ~HD AACTN AAIAV ABLVK ABYKQ AFKWA AJBFU AJOXV AMFUW LCYCR RIG 9DU AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c431t-694b6b3af75676790af9cf912fbecdfefa7069661c7488a4dfd1ceb6305b7f5e3 |
| ISICitedReferencesCount | 19 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000415392100009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1040-8428 1879-0461 |
| IngestDate | Wed Oct 01 10:36:42 EDT 2025 Wed Feb 19 02:42:57 EST 2025 Sat Nov 29 07:49:10 EST 2025 Tue Nov 18 21:56:34 EST 2025 Fri Feb 23 02:14:29 EST 2024 Tue Oct 14 19:30:25 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Cancer pain Nerve growth factor RANK Bone metastases RANK-L Opioids |
| Language | English |
| License | Copyright © 2017 Elsevier B.V. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c431t-694b6b3af75676790af9cf912fbecdfefa7069661c7488a4dfd1ceb6305b7f5e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 28893462 |
| PQID | 1938194511 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_1938194511 pubmed_primary_28893462 crossref_primary_10_1016_j_critrevonc_2017_08_005 crossref_citationtrail_10_1016_j_critrevonc_2017_08_005 elsevier_sciencedirect_doi_10_1016_j_critrevonc_2017_08_005 elsevier_clinicalkey_doi_10_1016_j_critrevonc_2017_08_005 |
| PublicationCentury | 2000 |
| PublicationDate | November 2017 2017-11-00 2017-Nov 20171101 |
| PublicationDateYYYYMMDD | 2017-11-01 |
| PublicationDate_xml | – month: 11 year: 2017 text: November 2017 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Critical reviews in oncology/hematology |
| PublicationTitleAlternate | Crit Rev Oncol Hematol |
| PublicationYear | 2017 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Porta-Sales, Garzón-Rodríguez, Llorens-Torromé, Brunelli (bib0445) 2016 Hortobagyi, Theriault, Lipton (bib0235) 1998; 16 Gonçalves, Dickenson (bib0185) 2012; 36 Slatkin, Zaki, Wang (bib0490) 2015; 23 Lee, Moon, Sul (bib0320) 2009; 42 Nencini, Ivanusic (bib0415) 2016; 7 Jimenez-Andrade (bib0275) 2010; 46 Falk, Dickenson (bib0130) 2014; 32 Halvorson, Sevcik, Ghilardi (bib0195) 2006; 22 Zylka, Rice, Anderson (bib0590) 2005; 45 Jagdev, Purohit, Heatley (bib0260) 2001; 12 Aloe, Tuveri, Carcassi, Levi-Montalcini (bib0005) 1992; 35 Von Moos, Body, Egerdie (bib0550) 2013; 21 Jehn, Diel, Overkamp (bib0265) 2016; 36 Clohisy, Perkins, Ramnaraine (bib0085) 2000; 373 Mantyh (bib0365) 2006; 7 Munro, Christensen, Erichsen (bib0405) 2016; 22 Mantyh, Clohisy, Koltzenburg (bib0350) 2002; 2 Jänig, Baron (bib0250) 2003; 2 D’Mello, Dickenson (bib0100) 2008; 101 Saad, Gleason, Murray (bib0470) 2002; 94 Lowe, Anand, Terenghi (bib0330) 1997; 79 Manthy (bib0345) 2014; 8 Arendt-Nielsen, Harris, Whiteside (bib0010) 2016; 157 Bandieri, Romero, Ripamonti (bib0015) 2015; 33 Kawamoto, Aoki, Tanaka (bib0300) 2002; 168 Caraceni, Hanks (bib0060) 2012; 13 Thurston (bib0525) 1982; 134 Mathias, Crosby, Qian (bib0370) 2011; 9 Bovil (bib0045) 1997; 15 Moran, Xu, Clapham (bib0395) 2004; 14 Body, Diel, Lichinitser, Kreuser (bib0040) 2003; 14 Honore, Mantyh (bib0225) 2000; 1 Winston, Toma, Shenoy, Pasricha (bib0570) 2001; 89 Kuduk, Di Marco, Bodmer-Narkevitch (bib0315) 2010; 1 Weinfurt, Li, Castel (bib0565) 2005; 16 McKelvey, Shorten, O’Keeffe (bib0375) 2013; 124 Ramsey, Delling, Clapham (bib0455) 2006; 68 Fallowfield, von Moos, Costa (bib0145) 2012; l8 Hara-Irie, Amizuka, Ozawa (bib0200) 1996; 18 Hortobagyi, Theriault, Porter (bib0230) 1996; 335 Iwakura, Ohtori, Orita (bib0245) 2010; 35 Julius, Basbaum (bib0290) 2001; 413 Serre, Farlay, Delmas (bib0485) 1999; 25 Stopeck, Lipton, Body (bib0515) 2010; 28 El-Amm, Aragon-Ching (bib0125) 2016; 10 Stein, Ufret-Vincenty, Hua (bib0510) 2006; 128 Joyce, Pollard (bib0285) 2009; 9 Cleeland, Body, Stopeck (bib0080) 2013; 119 Falk, Uldall, Heegaard (bib0135) 2012 Owolabi, Rizkalla, Tehim (bib0435) 1999; 289 Ghilardi, Freeman, Jimenez-Andrade (bib0165) 2010; 6 Portenoy, Hagen (bib0450) 1990; 41 Riley, Branford, Droney (bib0460) 2015; 49 Wardley, Davidson, Barrett-Lee (bib0555) 2005; 92 Klein, Jing, Nanduri (bib0305) 1991; 65 Wong, Wiffen (bib0580) 2002; 2 Hefti, Rosenthal, Walicke (bib0205) 2006; 27 Winston, Toma, Shenoy (bib0575) 2003; 4 Zech, Grond, Lynch (bib0585) 1995; 63 Nabal, Librada, Redondo (bib0410) 2012; 26 Obata, Katsura, Sakurai (bib0420) 2006; 26 Coleman (bib0095) 2006; 12 Fang, Djouhri, McMullan (bib0150) 2005; 25 Small, Smith, Seaman (bib0495) 2003; 21 Watanabe, Inoue, Sasaki (bib0560) 2011; 108 Mullard (bib0400) 2015; 14 Vermeirsch, Nuydens, Salmon (bib0540) 2004; 79 Jimenez-Andrade, Ghilardi, Castañeda-Corral (bib0280) 2011; 152 Schor (bib0480) 2005; 77 Mach, Rogers, Sabino (bib0340) 2002; 113 Mantyh, Jimenez-Andrade, Stake (bib0355) 2010; 171 Theriault, Lipton, Hortobagyi (bib0520) 1999; 17 Davies (bib0105) 2003; 22 Fallon, Hoskin, Colvin (bib0140) 2015; 20 Henry, Costa, Goldwasser (bib0210) 2011; 29 Liu, Tyagi, Chancellor, Kuo (bib0325) 2010; 106 El Mouedden, Meert (bib0115) 2005; 82 CRD (bib0050) 2009 Paulsen, Klepstad, Rosland (bib0440) 2014; 32 Schnitzer, Marks (bib0475) 2015; 23 Jacobs, Smaldone, Tyagi (bib0255) 2010; 17 El Mouedden, Meert (bib0120) 2007; 87 Van den Beuken, van Everdingen, de Rijke (bib0535) 2007; 18 Diel, Body, Lichinitser (bib0110) 2004; 40 Ivanusic (bib0240) 2009; 517 Menéndez, Lastra, Hidalgo (bib0385) 2003; 14 Honoré, Schwei, Rogers (bib0220) 2000; 129 Ginty, Segal (bib0180) 2002; 12 Sopata, Katz, Carey (bib0505) 2015; 156 Luger, Sabino, Schwei (bib0335) 2002; 99 Ji, Samad, Jin (bib0270) 2002; 36 Kaan, Yip, Patel (bib0295) 2010; 133 Coleman (bib0090) 2006; 15:12 von Moos, Body, Egerdie (bib0545) 2011; 21 Blair (bib0035) 1998; 20 McMahon, Bennett, Priestley, Shelton (bib0380) 1995; 1 Barthel, Yeremenko, Jacobs (bib0030) 2009; 11 Calvo, Forteza-Vila (bib0055) 1969; 126 Mantyh (bib0360) 2010; 171 Bannister, Bee, Dickenson (bib0020) 2009; 6 Ghilardi, Freeman, Jimenez-Andrade (bib0170) 2011; 48 Kretzschmar, Wiegel, Al-Batran (bib0310) 2007; 4 Ripamonti, Santini, Maranzano (bib0465) 2012; 23 Franklin, Davies, Wyatt (bib0155) 2009; 41 Ugolini, Marinelli, Covaceuszach (bib0530) 2007; 104 Chung, Barlev, Braun (bib0075) 2014; 15 Smeyne, Klein, Schnapp (bib0500) 1994; 368 Chizh, O’Donnell, Napolitano (bib0065) 2007; 132 Hizazi, Carducci, Smith (bib0215) 2011; 377 Chuang, Prescott, Kong (bib0070) 2001; 411 Ghilardi (bib0175) 2012; 64 Oddiah, Anand, McMahon, Rattray (bib0425) 1998; 9 Miller, Fischer, Goralnick (bib0390) 2002; 59 Orita, Ohtori, Nagata (bib0430) 2010; 28 Fukui, Ohtori, Yamashita (bib0160) 2010; 28 Halliday, Zettler, Rush (bib0190) 1998; 23 Barcena de Arellano, Arnold, Vercellino (bib0025) 2011; 18 Hefti (10.1016/j.critrevonc.2017.08.005_bib0205) 2006; 27 Zech (10.1016/j.critrevonc.2017.08.005_bib0585) 1995; 63 Ghilardi (10.1016/j.critrevonc.2017.08.005_bib0165) 2010; 6 Joyce (10.1016/j.critrevonc.2017.08.005_bib0285) 2009; 9 Jacobs (10.1016/j.critrevonc.2017.08.005_bib0255) 2010; 17 Orita (10.1016/j.critrevonc.2017.08.005_bib0430) 2010; 28 Hara-Irie (10.1016/j.critrevonc.2017.08.005_bib0200) 1996; 18 Bandieri (10.1016/j.critrevonc.2017.08.005_bib0015) 2015; 33 Jehn (10.1016/j.critrevonc.2017.08.005_bib0265) 2016; 36 Owolabi (10.1016/j.critrevonc.2017.08.005_bib0435) 1999; 289 Luger (10.1016/j.critrevonc.2017.08.005_bib0335) 2002; 99 Fallon (10.1016/j.critrevonc.2017.08.005_bib0140) 2015; 20 Jimenez-Andrade (10.1016/j.critrevonc.2017.08.005_bib0280) 2011; 152 Weinfurt (10.1016/j.critrevonc.2017.08.005_bib0565) 2005; 16 Manthy (10.1016/j.critrevonc.2017.08.005_bib0345) 2014; 8 Stopeck (10.1016/j.critrevonc.2017.08.005_bib0515) 2010; 28 Mullard (10.1016/j.critrevonc.2017.08.005_bib0400) 2015; 14 Barcena de Arellano (10.1016/j.critrevonc.2017.08.005_bib0025) 2011; 18 Ginty (10.1016/j.critrevonc.2017.08.005_bib0180) 2002; 12 Jänig (10.1016/j.critrevonc.2017.08.005_bib0250) 2003; 2 Slatkin (10.1016/j.critrevonc.2017.08.005_bib0490) 2015; 23 Clohisy (10.1016/j.critrevonc.2017.08.005_bib0085) 2000; 373 Coleman (10.1016/j.critrevonc.2017.08.005_bib0095) 2006; 12 Ghilardi (10.1016/j.critrevonc.2017.08.005_bib0175) 2012; 64 Body (10.1016/j.critrevonc.2017.08.005_bib0040) 2003; 14 D’Mello (10.1016/j.critrevonc.2017.08.005_bib0100) 2008; 101 Ripamonti (10.1016/j.critrevonc.2017.08.005_bib0465) 2012; 23 Chung (10.1016/j.critrevonc.2017.08.005_bib0075) 2014; 15 Mach (10.1016/j.critrevonc.2017.08.005_bib0340) 2002; 113 Van den Beuken (10.1016/j.critrevonc.2017.08.005_bib0535) 2007; 18 McKelvey (10.1016/j.critrevonc.2017.08.005_bib0375) 2013; 124 Gonçalves (10.1016/j.critrevonc.2017.08.005_bib0185) 2012; 36 Kuduk (10.1016/j.critrevonc.2017.08.005_bib0315) 2010; 1 Ugolini (10.1016/j.critrevonc.2017.08.005_bib0530) 2007; 104 Halliday (10.1016/j.critrevonc.2017.08.005_bib0190) 1998; 23 Ji (10.1016/j.critrevonc.2017.08.005_bib0270) 2002; 36 Fukui (10.1016/j.critrevonc.2017.08.005_bib0160) 2010; 28 Saad (10.1016/j.critrevonc.2017.08.005_bib0470) 2002; 94 Mathias (10.1016/j.critrevonc.2017.08.005_bib0370) 2011; 9 Mantyh (10.1016/j.critrevonc.2017.08.005_bib0360) 2010; 171 Obata (10.1016/j.critrevonc.2017.08.005_bib0420) 2006; 26 von Moos (10.1016/j.critrevonc.2017.08.005_bib0545) 2011; 21 El Mouedden (10.1016/j.critrevonc.2017.08.005_bib0120) 2007; 87 Stein (10.1016/j.critrevonc.2017.08.005_bib0510) 2006; 128 Porta-Sales (10.1016/j.critrevonc.2017.08.005_bib0445) 2016 Thurston (10.1016/j.critrevonc.2017.08.005_bib0525) 1982; 134 Fallowfield (10.1016/j.critrevonc.2017.08.005_bib0145) 2012; l8 Liu (10.1016/j.critrevonc.2017.08.005_bib0325) 2010; 106 Serre (10.1016/j.critrevonc.2017.08.005_bib0485) 1999; 25 Jagdev (10.1016/j.critrevonc.2017.08.005_bib0260) 2001; 12 Kretzschmar (10.1016/j.critrevonc.2017.08.005_bib0310) 2007; 4 Wong (10.1016/j.critrevonc.2017.08.005_bib0580) 2002; 2 Kaan (10.1016/j.critrevonc.2017.08.005_bib0295) 2010; 133 CRD (10.1016/j.critrevonc.2017.08.005_bib0050) 2009 Barthel (10.1016/j.critrevonc.2017.08.005_bib0030) 2009; 11 Jimenez-Andrade (10.1016/j.critrevonc.2017.08.005_bib0275) 2010; 46 Moran (10.1016/j.critrevonc.2017.08.005_bib0395) 2004; 14 Portenoy (10.1016/j.critrevonc.2017.08.005_bib0450) 1990; 41 Halvorson (10.1016/j.critrevonc.2017.08.005_bib0195) 2006; 22 El Mouedden (10.1016/j.critrevonc.2017.08.005_bib0115) 2005; 82 Caraceni (10.1016/j.critrevonc.2017.08.005_bib0060) 2012; 13 Winston (10.1016/j.critrevonc.2017.08.005_bib0575) 2003; 4 Mantyh (10.1016/j.critrevonc.2017.08.005_bib0355) 2010; 171 Munro (10.1016/j.critrevonc.2017.08.005_bib0405) 2016; 22 Honoré (10.1016/j.critrevonc.2017.08.005_bib0220) 2000; 129 Lee (10.1016/j.critrevonc.2017.08.005_bib0320) 2009; 42 Falk (10.1016/j.critrevonc.2017.08.005_bib0130) 2014; 32 Schor (10.1016/j.critrevonc.2017.08.005_bib0480) 2005; 77 Nencini (10.1016/j.critrevonc.2017.08.005_bib0415) 2016; 7 Paulsen (10.1016/j.critrevonc.2017.08.005_bib0440) 2014; 32 Riley (10.1016/j.critrevonc.2017.08.005_bib0460) 2015; 49 Klein (10.1016/j.critrevonc.2017.08.005_bib0305) 1991; 65 Winston (10.1016/j.critrevonc.2017.08.005_bib0570) 2001; 89 Mantyh (10.1016/j.critrevonc.2017.08.005_bib0350) 2002; 2 Schnitzer (10.1016/j.critrevonc.2017.08.005_bib0475) 2015; 23 Davies (10.1016/j.critrevonc.2017.08.005_bib0105) 2003; 22 Arendt-Nielsen (10.1016/j.critrevonc.2017.08.005_bib0010) 2016; 157 Honore (10.1016/j.critrevonc.2017.08.005_bib0225) 2000; 1 Sopata (10.1016/j.critrevonc.2017.08.005_bib0505) 2015; 156 Miller (10.1016/j.critrevonc.2017.08.005_bib0390) 2002; 59 Hortobagyi (10.1016/j.critrevonc.2017.08.005_bib0235) 1998; 16 Kawamoto (10.1016/j.critrevonc.2017.08.005_bib0300) 2002; 168 Watanabe (10.1016/j.critrevonc.2017.08.005_bib0560) 2011; 108 Bovil (10.1016/j.critrevonc.2017.08.005_bib0045) 1997; 15 Blair (10.1016/j.critrevonc.2017.08.005_bib0035) 1998; 20 El-Amm (10.1016/j.critrevonc.2017.08.005_bib0125) 2016; 10 Ghilardi (10.1016/j.critrevonc.2017.08.005_bib0170) 2011; 48 Nabal (10.1016/j.critrevonc.2017.08.005_bib0410) 2012; 26 Bannister (10.1016/j.critrevonc.2017.08.005_bib0020) 2009; 6 Small (10.1016/j.critrevonc.2017.08.005_bib0495) 2003; 21 Falk (10.1016/j.critrevonc.2017.08.005_bib0135) 2012 Aloe (10.1016/j.critrevonc.2017.08.005_bib0005) 1992; 35 Ivanusic (10.1016/j.critrevonc.2017.08.005_bib0240) 2009; 517 Diel (10.1016/j.critrevonc.2017.08.005_bib0110) 2004; 40 Hortobagyi (10.1016/j.critrevonc.2017.08.005_bib0230) 1996; 335 Smeyne (10.1016/j.critrevonc.2017.08.005_bib0500) 1994; 368 Chuang (10.1016/j.critrevonc.2017.08.005_bib0070) 2001; 411 Fang (10.1016/j.critrevonc.2017.08.005_bib0150) 2005; 25 Theriault (10.1016/j.critrevonc.2017.08.005_bib0520) 1999; 17 Chizh (10.1016/j.critrevonc.2017.08.005_bib0065) 2007; 132 Franklin (10.1016/j.critrevonc.2017.08.005_bib0155) 2009; 41 Lowe (10.1016/j.critrevonc.2017.08.005_bib0330) 1997; 79 McMahon (10.1016/j.critrevonc.2017.08.005_bib0380) 1995; 1 Zylka (10.1016/j.critrevonc.2017.08.005_bib0590) 2005; 45 Julius (10.1016/j.critrevonc.2017.08.005_bib0290) 2001; 413 Oddiah (10.1016/j.critrevonc.2017.08.005_bib0425) 1998; 9 Cleeland (10.1016/j.critrevonc.2017.08.005_bib0080) 2013; 119 Mantyh (10.1016/j.critrevonc.2017.08.005_bib0365) 2006; 7 Wardley (10.1016/j.critrevonc.2017.08.005_bib0555) 2005; 92 Menéndez (10.1016/j.critrevonc.2017.08.005_bib0385) 2003; 14 Iwakura (10.1016/j.critrevonc.2017.08.005_bib0245) 2010; 35 Coleman (10.1016/j.critrevonc.2017.08.005_bib0090) 2006; 15:12 Henry (10.1016/j.critrevonc.2017.08.005_bib0210) 2011; 29 Von Moos (10.1016/j.critrevonc.2017.08.005_bib0550) 2013; 21 Ramsey (10.1016/j.critrevonc.2017.08.005_bib0455) 2006; 68 Calvo (10.1016/j.critrevonc.2017.08.005_bib0055) 1969; 126 Vermeirsch (10.1016/j.critrevonc.2017.08.005_bib0540) 2004; 79 Hizazi (10.1016/j.critrevonc.2017.08.005_bib0215) 2011; 377 |
| References_xml | – volume: 32 start-page: 1647 year: 2014 end-page: 1654 ident: bib0130 article-title: Pain and nociception: mechanisms of cancer-induced bone pain publication-title: J. Clin. Oncol. – volume: 8 start-page: 83 year: 2014 end-page: 90 ident: bib0345 article-title: Bone cancer pain: from mechanism to therapy publication-title: Curr. Opin. Support Palliat Care – volume: 373 start-page: 104 year: 2000 end-page: 114 ident: bib0085 article-title: Review of cellular mechanisms of tumor osteolysis publication-title: Clin. Orthop. Relat. Res. – volume: 22 start-page: 587 year: 2006 end-page: 600 ident: bib0195 article-title: Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer publication-title: Clin. J. Pain – volume: 4 start-page: 203 year: 2007 end-page: 210 ident: bib0310 article-title: Rapid and sustained influence of intravenous zoledronic acid on course of pain and analgesics consumption in patients with cancer with bone metastases: a multicenter open-label study over 1 year publication-title: Support Cancer Ther. – volume: 20 start-page: 837 year: 1998 end-page: 846 ident: bib0035 article-title: How the osteoclast degrades bone publication-title: Bioessays – volume: 33 start-page: 1 year: 2015 end-page: 7 ident: bib0015 article-title: Randomized trial of low-dose morphine versus weak opioids in moderate cancer pain publication-title: J. Clin. Oncol. – volume: 21 start-page: 3497 year: 2011 end-page: 3507 ident: bib0545 article-title: Pain and health-related quality of life in patients with advanced solid tumours and bone metastases: integrated results from three randomized, double-blind studies of denosumab and zoledronic acid publication-title: Support. Care Cancer – volume: 7 start-page: 797 year: 2006 end-page: 809 ident: bib0365 article-title: Cancer pain and its impact on diagnosis, survival and quality of life publication-title: Nat. Rev. Neurosci. – volume: 2 start-page: 687 year: 2003 end-page: 697 ident: bib0250 article-title: Complex regional pain syndrome: mystery explained publication-title: Lancet Neurol. – volume: 28 start-page: 5132 year: 2010 end-page: 5139 ident: bib0515 article-title: Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study publication-title: J. Clin. Oncol. – volume: 104 start-page: 2985 year: 2007 end-page: 2990 ident: bib0530 article-title: The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 68 start-page: 619 year: 2006 end-page: 647 ident: bib0455 article-title: An introduction to TRP channels publication-title: Annu. Rev. Physiol. – start-page: 1 year: 2016 end-page: 21 ident: bib0445 article-title: Evidence on the analgesic role of bisphosphonates and denosumab in the treatment of pain due to bone metastases: a systematic review within the European Association for Palliative Care guidelines project publication-title: Pall Med. – volume: 6 start-page: 703 year: 2009 end-page: 712 ident: bib0020 article-title: Preclinical and early clinical investigations related to monoaminergic pain modulation publication-title: Neurotherapeutics – volume: 17 start-page: 4989 year: 2010 end-page: 4994 ident: bib0255 article-title: Increased nerve growth factor in neurogenic overactive bladder and interstitial cystitis patients publication-title: Can. J. Urol. – volume: 119 start-page: 832 year: 2013 end-page: 838 ident: bib0080 article-title: Pain outcomes in patients with advanced breast cancer and bone metastases: results from a randomized, double-blind study of denosumab and zoledronic acid publication-title: Cancer – volume: 377 start-page: 813 year: 2011 end-page: 822 ident: bib0215 article-title: Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study publication-title: Lancet – volume: 32 start-page: 3221 year: 2014 end-page: 3228 ident: bib0440 article-title: Efficacy of methylprednisolone on pain, fatigue, and appetite loss in patients with advanced cancer using opioids: a randomized, placebo-controlled, double-blind trial publication-title: J. Clin. Oncol. – volume: 113 start-page: 155 year: 2002 end-page: 166 ident: bib0340 article-title: Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur publication-title: Neuroscience – volume: 40 start-page: 1704 year: 2004 end-page: 1712 ident: bib0110 article-title: MF 4265 Study Group Improved quality of life after long-term treatment with the bisphosphonate ibandronate in patients with metastatic bone disease due to breast cancer publication-title: Eur. J. Cancer – volume: 89 start-page: 181 year: 2001 end-page: 186 ident: bib0570 article-title: Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons publication-title: Pain – volume: 9 start-page: 239 year: 2009 end-page: 252 ident: bib0285 article-title: Microenvironmental regulation of metastasis publication-title: Nat. Rev. Cancer – volume: 517 start-page: 276 year: 2009 end-page: 283 ident: bib0240 article-title: Size, neurochemistry, and segmental distribution of sensory neurons innervating the rat tibia publication-title: J. Comp. Neurol. – year: 2009 ident: bib0050 article-title: CRD’s Guidance for Undertaking Reviews in Healthcare – volume: 28 start-page: 279 year: 2010 end-page: 283 ident: bib0160 article-title: Low affinity NGF receptor (p75 neurotrophin receptor) inhibitory antibody reduces pain behavior and CGRP expression in DRG in the mouse sciatic nerve crush model publication-title: J. Orthop. Res. – volume: 152 start-page: 2564 year: 2011 end-page: 2574 ident: bib0280 article-title: Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain publication-title: Pain – volume: 99 start-page: 397 year: 2002 end-page: 406 ident: bib0335 article-title: Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain publication-title: Pain – volume: 168 start-page: 6412 year: 2002 end-page: 6419 ident: bib0300 article-title: Nerve growth factor activates mast cells through the collaborative interaction with lysophosphatidylserine expressed on the membrane surface of activated platelets publication-title: J. Immunol. – volume: 134 start-page: 719 year: 1982 end-page: 728 ident: bib0525 article-title: Distribution of nerves in long bones as shown by silver impregnation publication-title: J. Anat. – volume: 65 start-page: 189 year: 1991 end-page: 197 ident: bib0305 article-title: The trk proto-oncogene encodes a receptor for nerve growth factor publication-title: Cell – volume: 49 start-page: 161 year: 2015 end-page: 172 ident: bib0460 article-title: Morphine or oxycodone for cancer-related pain? A randomized, open-label, controlled trial publication-title: J. Pain Sympt. Manage. – volume: 92 start-page: 1869 year: 2005 end-page: 1876 ident: bib0555 article-title: Zoledronic acid significant- ly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration publication-title: Br. J. Cancer – volume: 28 start-page: 1614 year: 2010 end-page: 1620 ident: bib0430 article-title: Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs publication-title: J. Orthop. Res. – volume: 36 start-page: 57 year: 2002 end-page: 68 ident: bib0270 article-title: p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia publication-title: Neuron – volume: 41 start-page: 175 year: 2009 end-page: 185 ident: bib0155 article-title: Macrophage stimulating protein is a neurotrophic factor for a sub-population of adult nociceptive sensory neurons publication-title: Mol. Cell. Neurosci. – volume: 14 start-page: 1399 year: 2003 end-page: 1405 ident: bib0040 article-title: Intravenous ibandronate reduces the incidence of skeletal complica- tions in patients with breast cancer and bone metastases publication-title: Ann. Oncol. – volume: 106 start-page: 1681 year: 2010 end-page: 1685 ident: bib0325 article-title: Urinary nerve growth factor but not prostaglandin E2 increases in patients with interstitial cystitis/bladder pain syndrome and detrusor overactivity publication-title: BJU Int. – volume: 1 start-page: 19 year: 2010 end-page: 24 ident: bib0315 article-title: Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567 publication-title: ACS Chem. Neurosci. – volume: 2 start-page: CD002068 year: 2002 ident: bib0580 article-title: Bisphosphonates for the relief of pain secondary to bone metastases publication-title: Cochrane Database Syst. Rev. – volume: 41 start-page: 273 year: 1990 end-page: 281 ident: bib0450 article-title: Breakthrough pain: definition, prevalence and characteristics publication-title: Pain – volume: l8 start-page: 148 year: 2012 end-page: 155 ident: bib0145 article-title: Weighing bone-targeted treatment options for patients with solid tumours and skeletal complications from metastatic disease publication-title: Eur. Oncol. Haematol. – volume: 157 start-page: 2057 year: 2016 end-page: 2067 ident: bib0010 article-title: A randomized, double blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist 8V116517) in healthy volunteers and comparison with preclinical profile publication-title: Pain – volume: 20 start-page: 550 year: 2015 end-page: 556 ident: bib0140 article-title: Randomized double-Blind trial of pregabalin versus placebo in conjunction with palliative radiotherapy for cancer-Induced bone pain publication-title: J. Clin. Oncol. – volume: 171 start-page: 588 year: 2010 end-page: 598 ident: bib0360 article-title: Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain publication-title: Neuroscience – volume: 128 start-page: 509 year: 2006 end-page: 522 ident: bib0510 article-title: Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane publication-title: J. Gen. Physiol. – volume: 171 start-page: 588 year: 2010 end-page: 598 ident: bib0355 article-title: Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain publication-title: Neuroscience – volume: 1 start-page: 774 year: 1995 end-page: 780 ident: bib0380 article-title: The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule publication-title: Nat. Med. – volume: 10 start-page: S1 year: 2016 ident: bib0125 article-title: Targeting bone metastasis in metastatic castration-resistant prostate cancer publication-title: Clin. Med. Insights: Oncol. – volume: 6 start-page: 87 year: 2010 ident: bib0165 article-title: Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain publication-title: Mol. Pain – volume: 9 start-page: 1455 year: 1998 end-page: 1458 ident: bib0425 article-title: Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder publication-title: Neuroreport – volume: 63 start-page: 65 year: 1995 end-page: 76 ident: bib0585 article-title: Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study publication-title: Pain – volume: 23 start-page: S8 year: 2015 end-page: S17 ident: bib0475 article-title: A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee publication-title: Osteoarthritis Cartilage – volume: 23 start-page: S48 year: 2015 ident: bib0490 article-title: Efficacy and safety and tolerability of fulranumab as adjunctive therapy for cancer-related pain: a randomized, double-blind, placebo-controlled, multicenter study publication-title: Support. Care Cancer – volume: 9 start-page: 72 year: 2011 end-page: 78 ident: bib0370 article-title: Estimating minimally important differences for the worst pain rating of the brief pain inventory-short form publication-title: J. Support Oncol. – volume: 12 start-page: 1433 year: 2001 end-page: 1438 ident: bib0260 article-title: Comparison of the effects of intravenous pamidronate and oral clodronate on symptoms and bone resorption in patients with metastatic bone disease publication-title: Ann. Oncol. – volume: 4 start-page: 329 year: 2003 end-page: 337 ident: bib0575 article-title: Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide upregulation that can be suppressed by the protein kinase inhibitor k252a publication-title: J. Pain – volume: 289 start-page: 1271 year: 1999 end-page: 1276 ident: bib0435 article-title: Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat publication-title: J. Pharmacol. Exp. Ther. – volume: 14 start-page: 362 year: 2004 end-page: 369 ident: bib0395 article-title: TRP ion channels in the nervous system publication-title: Curr. Opin. Neurobiol. – volume: 45 start-page: 17 year: 2005 end-page: 25 ident: bib0590 article-title: Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd publication-title: Neuron – volume: 11 start-page: R82 year: 2009 ident: bib0030 article-title: Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis publication-title: Arthritis Res. Ther. – volume: 108 start-page: 248 year: 2011 end-page: 251 ident: bib0560 article-title: Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment publication-title: BJU Int. – volume: 35 start-page: 267 year: 2010 end-page: 273 ident: bib0245 article-title: Role of low-affinity nerve growth factor receptor inhibitory antibody in reducing pain behavior and calcitonin gene-related peptide expression in a rat model of wrist joint inflammatory pain publication-title: J. Hand Surg. Am. – volume: 77 start-page: 201 year: 2005 end-page: 214 ident: bib0480 article-title: The p75 neurotrophin receptor in human development and disease publication-title: Prog. Neurobiol. – volume: 46 start-page: 306 year: 2010 end-page: 313 ident: bib0275 article-title: A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain publication-title: Bone – volume: 2 start-page: 201 year: 2002 end-page: 209 ident: bib0350 article-title: Molecular mechanisms of cancer pain publication-title: Nat. Rev. Cancer – volume: 1 start-page: 303 year: 2000 end-page: 309 ident: bib0225 article-title: Bone cancer pain: from mechanism to model to therapy publication-title: Pain Med. – volume: 36 start-page: 2631 year: 2016 end-page: 2638 ident: bib0265 article-title: Management of metastatic bone disease algorithms for diagnostic and treatment publication-title: Anticancer Res. – volume: 94 start-page: 1458 year: 2002 end-page: 1468 ident: bib0470 article-title: A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma publication-title: J. Natl. Cancer Inst. – volume: 18 start-page: 29 year: 1996 end-page: 39 ident: bib0200 article-title: Immunohistochemical and ultrastructural localization of CGRP-positive nerve fibers at the epiphyseal trabecules facing the growth plate of rat femurs publication-title: Bone – volume: 15:12 start-page: 6243s year: 2006 end-page: 6249s ident: bib0090 article-title: Clinical features of metastatic bone disease and risk of skeletal morbidity publication-title: Clin. Cancer Res. – volume: 101 start-page: 8 year: 2008 end-page: 16 ident: bib0100 article-title: Spinal cord mechanisms of pain publication-title: Br. J. Anaesth. – volume: 21 start-page: 13497 year: 2013 end-page: 13507 ident: bib0550 article-title: Pain and healthrelated quality of life in patients with advanced solid tumours and bone metastases: integrated results from three randomized, double-blind studies of denosumab and zoledronic acid publication-title: Support. Care Cancer – volume: 21 start-page: 4277 year: 2003 end-page: 4284 ident: bib0495 article-title: Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer publication-title: J. Clin. Oncol. – volume: 48 start-page: 389 year: 2011 end-page: 398 ident: bib0170 article-title: Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers publication-title: Bone – volume: 27 start-page: 85 year: 2006 end-page: 91 ident: bib0205 article-title: Novel class of pain drugs based on antagonism of NGF publication-title: Trends Pharmacol. Sci. – volume: 18 start-page: 1202 year: 2011 end-page: 1210 ident: bib0025 article-title: Influence of nerve growth factor in endometriosis-associated symptoms publication-title: Reprod. Sci. – volume: 22 start-page: 2537 year: 2003 end-page: 2545 ident: bib0105 article-title: Regulation of neuronal survival and death by extracellular signals during development publication-title: EMBO J. – year: 2012 ident: bib0135 article-title: The role of purinergic receptors in cancer-induced bone pain publication-title: J. Osteoporos. – volume: 23 start-page: vii39 year: 2012 end-page: vii154 ident: bib0465 article-title: Management of cancer pain: ESMO clinical practice guidelines publication-title: Ann. Oncol. – volume: 411 start-page: 957 year: 2001 end-page: 962 ident: bib0070 article-title: Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition publication-title: Nature – volume: 82 start-page: 109 year: 2005 end-page: 119 ident: bib0115 article-title: Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain publication-title: Pharmacol. Biochem. Behav. – volume: 124 start-page: 276 year: 2013 end-page: 289 ident: bib0375 article-title: Nerve growth factor-mediated regulation of pain signaling and proposed new intervention strategies in clinical pain management publication-title: J. Neurochem. – volume: 22 start-page: 135 year: 2016 end-page: 145 ident: bib0405 article-title: NS383 selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats publication-title: CNS Neurosci. Ther. – volume: 79 start-page: 572 year: 1997 end-page: 577 ident: bib0330 article-title: Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis publication-title: Br. J. Urol. – volume: 59 start-page: 603 year: 2002 end-page: 608 ident: bib0390 article-title: Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome publication-title: Urology – volume: 36 start-page: 3204 year: 2012 end-page: 3213 ident: bib0185 article-title: Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation publication-title: Eur. J. Neurosci. – volume: 42 start-page: 1504 year: 2009 end-page: 1511 ident: bib0320 article-title: Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus publication-title: Clin. Biochem. – volume: 14 start-page: 297 year: 2015 end-page: 298 ident: bib0400 article-title: Drug developers reboot anti-NGF pain programmes publication-title: Nat. Rev. Drug Discov. – volume: 132 start-page: 132 year: 2007 end-page: 141 ident: bib0065 article-title: The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans publication-title: Pain – volume: 35 start-page: 351 year: 1992 end-page: 355 ident: bib0005 article-title: Nerve growth factor in the synovial fluid of patients with chronic arthritis publication-title: Arthritis Rheum. – volume: 12 start-page: 268 year: 2002 end-page: 274 ident: bib0180 article-title: Retrograde neurotrophin signaling: trk-ing along the axon publication-title: Curr. Opin. Neurobiol. – volume: 25 start-page: 623 year: 1999 end-page: 629 ident: bib0485 article-title: Evidence for a dense and intimate innervation of the bone tissue, including glutamate-containing fibers publication-title: Bone – volume: 16 start-page: 579 year: 2005 end-page: 584 ident: bib0565 article-title: The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer publication-title: Ann. Oncol. – volume: 79 start-page: 243 year: 2004 end-page: 251 ident: bib0540 article-title: Bone cancer pain model in mice: evaluation of pain behavior, bone destruction and morphine sensitivity publication-title: Pharmacol. Biochem. Behav. – volume: 18 start-page: 1437 year: 2007 end-page: 1449 ident: bib0535 article-title: Prevalence of pain in patients with cancer: a systematic review of the past 40 years publication-title: Ann. Oncol. – volume: 156 start-page: 1703 year: 2015 end-page: 1713 ident: bib0505 article-title: Efficacy and safety of tanezumab in the treatment of pain from bone metastases publication-title: Pain – volume: 413 start-page: 203 year: 2001 end-page: 210 ident: bib0290 article-title: Molecular mechanisms of nociception publication-title: Nature – volume: 29 start-page: 1125 year: 2011 end-page: 1132 ident: bib0210 article-title: Randomized, double-blind study of denosumab versus zole- dronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma publication-title: J. Clin. Oncol. – volume: 23 start-page: 919 year: 1998 end-page: 922 ident: bib0190 article-title: Elevated nerve growth factor levels in the synovial fluid of patients with inflammatory joint disease publication-title: Neurochem. Res. – volume: 7 start-page: 157 year: 2016 ident: bib0415 article-title: The physiology of bone pain. How much do we really know? publication-title: Front. Physiol. – volume: 13 start-page: e58 year: 2012 end-page: e68 ident: bib0060 article-title: Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC publication-title: Lancet Oncol. – volume: 129 start-page: 389 year: 2000 end-page: 397 ident: bib0220 article-title: Cellular and neurochemical remodeling of the spinal cord in bone cancer pain publication-title: Prog. Brain Res. – volume: 16 start-page: 2038 year: 1998 end-page: 2044 ident: bib0235 article-title: Long-term prevention of skeletal complications of metastatic breast cancer with pamidronate: protocol 19 Aredia Breast Cancer study group publication-title: J. Clin. Oncol. – volume: 14 start-page: 867 year: 2003 end-page: 869 ident: bib0385 article-title: Peripheral opioids act as analgesics in bone cancer pain in mice publication-title: Neuroreport – volume: 17 start-page: 846 year: 1999 end-page: 854 ident: bib0520 article-title: Pamidronate reduces skeletal mor- bidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer study group publication-title: J. Clin. Oncol. – volume: 126 start-page: 355 year: 1969 end-page: 371 ident: bib0055 article-title: On the development of bone marrow innervation in new-born rats as studied with silver impregnation and electron microscopy publication-title: Am. J. Anat. – volume: 87 start-page: 30 year: 2007 end-page: 40 ident: bib0120 article-title: The impact of the opioids fentanyl and morphine on nociception and bone destruction in a murine model of bone cancer pain publication-title: Pharmacol. Biochem. Behav. – volume: 335 start-page: 1785 year: 1996 end-page: 1792 ident: bib0230 article-title: Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer study group publication-title: N. Engl. J. Med. – volume: 12 start-page: 6243 year: 2006 end-page: 6249s ident: bib0095 article-title: Clinical features of metastatic bone disease and risk of skeletal morbidity publication-title: Clin. Cancer Res. – volume: 15 start-page: 225 year: 2014 end-page: 232 ident: bib0075 article-title: Assessing analgesic use in patients with advanced cancer: development of a new scale – the Analgesic Quantification Algorithm publication-title: Pain Med. – volume: 64 start-page: 2223 year: 2012 end-page: 2232 ident: bib0175 article-title: Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint publication-title: Arthritis Rheum. – volume: 133 start-page: 2549 year: 2010 end-page: 2564 ident: bib0295 article-title: Systemic blockade of P2 publication-title: Brain – volume: 368 start-page: 246 year: 1994 end-page: 249 ident: bib0500 article-title: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene publication-title: Nature – volume: 15 start-page: 9 year: 1997 end-page: 15 ident: bib0045 article-title: Mechanisms of actions of opioids and non-steroidal anti-inflammatory drugs publication-title: Eur. J. Anaesthesiol. Suppl. – volume: 25 start-page: 4868 year: 2005 end-page: 4878 ident: bib0150 article-title: trkA is expressed in nociceptive neurons and influences electrophysiological properties via Nav1: 8 expression in rapidly conducting nociceptors publication-title: J. Neurosci. – volume: 26 start-page: 305 year: 2012 end-page: 312 ident: bib0410 article-title: The role of paracetamol and non steroideal anti-inflammatory drugs in addition to WHO step III opioids in the control of pain in advanced cancer. A systematic review of te literature publication-title: Palliat. Med. – volume: 26 start-page: 11974 year: 2006 end-page: 11986 ident: bib0420 article-title: Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury publication-title: J. Neurosci. – volume: 1 start-page: 774 year: 1995 ident: 10.1016/j.critrevonc.2017.08.005_bib0380 article-title: The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule publication-title: Nat. Med. doi: 10.1038/nm0895-774 – volume: 133 start-page: 2549 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0295 article-title: Systemic blockade of P2×3 and P2×2/3 receptors attenuates bone cancer pain behaviour in rats publication-title: Brain doi: 10.1093/brain/awq194 – volume: 32 start-page: 3221 year: 2014 ident: 10.1016/j.critrevonc.2017.08.005_bib0440 article-title: Efficacy of methylprednisolone on pain, fatigue, and appetite loss in patients with advanced cancer using opioids: a randomized, placebo-controlled, double-blind trial publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2013.54.3926 – volume: 104 start-page: 2985 year: 2007 ident: 10.1016/j.critrevonc.2017.08.005_bib0530 article-title: The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0611253104 – volume: 59 start-page: 603 year: 2002 ident: 10.1016/j.critrevonc.2017.08.005_bib0390 article-title: Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome publication-title: Urology doi: 10.1016/S0090-4295(01)01597-7 – volume: 49 start-page: 161 issue: 2 year: 2015 ident: 10.1016/j.critrevonc.2017.08.005_bib0460 article-title: Morphine or oxycodone for cancer-related pain? A randomized, open-label, controlled trial publication-title: J. Pain Sympt. Manage. doi: 10.1016/j.jpainsymman.2014.05.021 – volume: 35 start-page: 267 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0245 article-title: Role of low-affinity nerve growth factor receptor inhibitory antibody in reducing pain behavior and calcitonin gene-related peptide expression in a rat model of wrist joint inflammatory pain publication-title: J. Hand Surg. Am. doi: 10.1016/j.jhsa.2009.10.030 – volume: 21 start-page: 13497 year: 2013 ident: 10.1016/j.critrevonc.2017.08.005_bib0550 article-title: Pain and healthrelated quality of life in patients with advanced solid tumours and bone metastases: integrated results from three randomized, double-blind studies of denosumab and zoledronic acid publication-title: Support. Care Cancer doi: 10.1007/s00520-013-1932-2 – volume: 11 start-page: R82 year: 2009 ident: 10.1016/j.critrevonc.2017.08.005_bib0030 article-title: Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis publication-title: Arthritis Res. Ther. doi: 10.1186/ar2716 – volume: 335 start-page: 1785 year: 1996 ident: 10.1016/j.critrevonc.2017.08.005_bib0230 article-title: Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer study group publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199612123352401 – volume: 6 start-page: 703 year: 2009 ident: 10.1016/j.critrevonc.2017.08.005_bib0020 article-title: Preclinical and early clinical investigations related to monoaminergic pain modulation publication-title: Neurotherapeutics doi: 10.1016/j.nurt.2009.07.009 – volume: 1 start-page: 303 issue: 4 year: 2000 ident: 10.1016/j.critrevonc.2017.08.005_bib0225 article-title: Bone cancer pain: from mechanism to model to therapy publication-title: Pain Med. doi: 10.1046/j.1526-4637.2000.00047.x – volume: 22 start-page: 135 issue: February (2) year: 2016 ident: 10.1016/j.critrevonc.2017.08.005_bib0405 article-title: NS383 selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats publication-title: CNS Neurosci. Ther. doi: 10.1111/cns.12487 – volume: 101 start-page: 8 year: 2008 ident: 10.1016/j.critrevonc.2017.08.005_bib0100 article-title: Spinal cord mechanisms of pain publication-title: Br. J. Anaesth. doi: 10.1093/bja/aen088 – volume: 27 start-page: 85 year: 2006 ident: 10.1016/j.critrevonc.2017.08.005_bib0205 article-title: Novel class of pain drugs based on antagonism of NGF publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2005.12.001 – volume: 20 start-page: 550 year: 2015 ident: 10.1016/j.critrevonc.2017.08.005_bib0140 article-title: Randomized double-Blind trial of pregabalin versus placebo in conjunction with palliative radiotherapy for cancer-Induced bone pain publication-title: J. Clin. Oncol. – volume: 128 start-page: 509 year: 2006 ident: 10.1016/j.critrevonc.2017.08.005_bib0510 article-title: Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane publication-title: J. Gen. Physiol. doi: 10.1085/jgp.200609576 – volume: 15 start-page: 9 year: 1997 ident: 10.1016/j.critrevonc.2017.08.005_bib0045 article-title: Mechanisms of actions of opioids and non-steroidal anti-inflammatory drugs publication-title: Eur. J. Anaesthesiol. Suppl. doi: 10.1097/00003643-199705001-00003 – volume: 14 start-page: 297 issue: 5 year: 2015 ident: 10.1016/j.critrevonc.2017.08.005_bib0400 article-title: Drug developers reboot anti-NGF pain programmes publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd4612 – volume: 119 start-page: 832 year: 2013 ident: 10.1016/j.critrevonc.2017.08.005_bib0080 article-title: Pain outcomes in patients with advanced breast cancer and bone metastases: results from a randomized, double-blind study of denosumab and zoledronic acid publication-title: Cancer doi: 10.1002/cncr.27789 – volume: 9 start-page: 239 year: 2009 ident: 10.1016/j.critrevonc.2017.08.005_bib0285 article-title: Microenvironmental regulation of metastasis publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2618 – volume: 35 start-page: 351 year: 1992 ident: 10.1016/j.critrevonc.2017.08.005_bib0005 article-title: Nerve growth factor in the synovial fluid of patients with chronic arthritis publication-title: Arthritis Rheum. doi: 10.1002/art.1780350315 – volume: 89 start-page: 181 year: 2001 ident: 10.1016/j.critrevonc.2017.08.005_bib0570 article-title: Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons publication-title: Pain doi: 10.1016/S0304-3959(00)00370-5 – volume: 94 start-page: 1458 year: 2002 ident: 10.1016/j.critrevonc.2017.08.005_bib0470 article-title: A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/94.19.1458 – volume: 22 start-page: 2537 year: 2003 ident: 10.1016/j.critrevonc.2017.08.005_bib0105 article-title: Regulation of neuronal survival and death by extracellular signals during development publication-title: EMBO J. doi: 10.1093/emboj/cdg254 – volume: 16 start-page: 579 issue: 4 year: 2005 ident: 10.1016/j.critrevonc.2017.08.005_bib0565 article-title: The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer publication-title: Ann. Oncol. doi: 10.1093/annonc/mdi122 – volume: 14 start-page: 867 year: 2003 ident: 10.1016/j.critrevonc.2017.08.005_bib0385 article-title: Peripheral opioids act as analgesics in bone cancer pain in mice publication-title: Neuroreport doi: 10.1097/00001756-200305060-00018 – volume: 99 start-page: 397 year: 2002 ident: 10.1016/j.critrevonc.2017.08.005_bib0335 article-title: Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain publication-title: Pain doi: 10.1016/S0304-3959(02)00102-1 – volume: 168 start-page: 6412 year: 2002 ident: 10.1016/j.critrevonc.2017.08.005_bib0300 article-title: Nerve growth factor activates mast cells through the collaborative interaction with lysophosphatidylserine expressed on the membrane surface of activated platelets publication-title: J. Immunol. doi: 10.4049/jimmunol.168.12.6412 – volume: 134 start-page: 719 year: 1982 ident: 10.1016/j.critrevonc.2017.08.005_bib0525 article-title: Distribution of nerves in long bones as shown by silver impregnation publication-title: J. Anat. – volume: 156 start-page: 1703 issue: 9 year: 2015 ident: 10.1016/j.critrevonc.2017.08.005_bib0505 article-title: Efficacy and safety of tanezumab in the treatment of pain from bone metastases publication-title: Pain doi: 10.1097/j.pain.0000000000000211 – volume: 10 start-page: S1 year: 2016 ident: 10.1016/j.critrevonc.2017.08.005_bib0125 article-title: Targeting bone metastasis in metastatic castration-resistant prostate cancer publication-title: Clin. Med. Insights: Oncol. – volume: 79 start-page: 572 year: 1997 ident: 10.1016/j.critrevonc.2017.08.005_bib0330 article-title: Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis publication-title: Br. J. Urol. doi: 10.1046/j.1464-410X.1997.00097.x – volume: 26 start-page: 11974 year: 2006 ident: 10.1016/j.critrevonc.2017.08.005_bib0420 article-title: Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3188-06.2006 – volume: 82 start-page: 109 year: 2005 ident: 10.1016/j.critrevonc.2017.08.005_bib0115 article-title: Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/j.pbb.2005.07.016 – volume: 20 start-page: 837 issue: 10 year: 1998 ident: 10.1016/j.critrevonc.2017.08.005_bib0035 article-title: How the osteoclast degrades bone publication-title: Bioessays doi: 10.1002/(SICI)1521-1878(199810)20:10<837::AID-BIES9>3.0.CO;2-D – volume: 377 start-page: 813 year: 2011 ident: 10.1016/j.critrevonc.2017.08.005_bib0215 article-title: Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study publication-title: Lancet doi: 10.1016/S0140-6736(10)62344-6 – volume: 28 start-page: 1614 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0430 article-title: Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs publication-title: J. Orthop. Res. doi: 10.1002/jor.21170 – volume: 18 start-page: 1202 year: 2011 ident: 10.1016/j.critrevonc.2017.08.005_bib0025 article-title: Influence of nerve growth factor in endometriosis-associated symptoms publication-title: Reprod. Sci. doi: 10.1177/1933719111410711 – volume: 64 start-page: 2223 issue: 7 year: 2012 ident: 10.1016/j.critrevonc.2017.08.005_bib0175 article-title: Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint publication-title: Arthritis Rheum. doi: 10.1002/art.34385 – volume: 6 start-page: 87 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0165 article-title: Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain publication-title: Mol. Pain doi: 10.1186/1744-8069-6-87 – volume: 68 start-page: 619 year: 2006 ident: 10.1016/j.critrevonc.2017.08.005_bib0455 article-title: An introduction to TRP channels publication-title: Annu. Rev. Physiol. doi: 10.1146/annurev.physiol.68.040204.100431 – volume: 40 start-page: 1704 year: 2004 ident: 10.1016/j.critrevonc.2017.08.005_bib0110 article-title: MF 4265 Study Group Improved quality of life after long-term treatment with the bisphosphonate ibandronate in patients with metastatic bone disease due to breast cancer publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2004.03.025 – volume: 41 start-page: 273 year: 1990 ident: 10.1016/j.critrevonc.2017.08.005_bib0450 article-title: Breakthrough pain: definition, prevalence and characteristics publication-title: Pain doi: 10.1016/0304-3959(90)90004-W – volume: 41 start-page: 175 year: 2009 ident: 10.1016/j.critrevonc.2017.08.005_bib0155 article-title: Macrophage stimulating protein is a neurotrophic factor for a sub-population of adult nociceptive sensory neurons publication-title: Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2009.02.009 – volume: 15 start-page: 225 year: 2014 ident: 10.1016/j.critrevonc.2017.08.005_bib0075 article-title: Assessing analgesic use in patients with advanced cancer: development of a new scale – the Analgesic Quantification Algorithm publication-title: Pain Med. doi: 10.1111/pme.12299 – volume: 113 start-page: 155 year: 2002 ident: 10.1016/j.critrevonc.2017.08.005_bib0340 article-title: Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur publication-title: Neuroscience doi: 10.1016/S0306-4522(02)00165-3 – year: 2009 ident: 10.1016/j.critrevonc.2017.08.005_bib0050 – volume: 25 start-page: 623 year: 1999 ident: 10.1016/j.critrevonc.2017.08.005_bib0485 article-title: Evidence for a dense and intimate innervation of the bone tissue, including glutamate-containing fibers publication-title: Bone doi: 10.1016/S8756-3282(99)00215-X – volume: 32 start-page: 1647 issue: 16 year: 2014 ident: 10.1016/j.critrevonc.2017.08.005_bib0130 article-title: Pain and nociception: mechanisms of cancer-induced bone pain publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2013.51.7219 – volume: 13 start-page: e58 year: 2012 ident: 10.1016/j.critrevonc.2017.08.005_bib0060 article-title: Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(12)70040-2 – volume: 48 start-page: 389 year: 2011 ident: 10.1016/j.critrevonc.2017.08.005_bib0170 article-title: Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers publication-title: Bone doi: 10.1016/j.bone.2010.09.019 – volume: 4 start-page: 329 year: 2003 ident: 10.1016/j.critrevonc.2017.08.005_bib0575 article-title: Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide upregulation that can be suppressed by the protein kinase inhibitor k252a publication-title: J. Pain doi: 10.1016/S1526-5900(03)00636-9 – volume: 124 start-page: 276 year: 2013 ident: 10.1016/j.critrevonc.2017.08.005_bib0375 article-title: Nerve growth factor-mediated regulation of pain signaling and proposed new intervention strategies in clinical pain management publication-title: J. Neurochem. doi: 10.1111/jnc.12093 – volume: 14 start-page: 362 year: 2004 ident: 10.1016/j.critrevonc.2017.08.005_bib0395 article-title: TRP ion channels in the nervous system publication-title: Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2004.05.003 – volume: 9 start-page: 1455 year: 1998 ident: 10.1016/j.critrevonc.2017.08.005_bib0425 article-title: Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder publication-title: Neuroreport doi: 10.1097/00001756-199805110-00038 – volume: 77 start-page: 201 year: 2005 ident: 10.1016/j.critrevonc.2017.08.005_bib0480 article-title: The p75 neurotrophin receptor in human development and disease publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2005.10.006 – volume: 126 start-page: 355 year: 1969 ident: 10.1016/j.critrevonc.2017.08.005_bib0055 article-title: On the development of bone marrow innervation in new-born rats as studied with silver impregnation and electron microscopy publication-title: Am. J. Anat. doi: 10.1002/aja.1001260308 – volume: 4 start-page: 203 year: 2007 ident: 10.1016/j.critrevonc.2017.08.005_bib0310 article-title: Rapid and sustained influence of intravenous zoledronic acid on course of pain and analgesics consumption in patients with cancer with bone metastases: a multicenter open-label study over 1 year publication-title: Support Cancer Ther. doi: 10.3816/SCT.2007.n.016 – volume: 108 start-page: 248 year: 2011 ident: 10.1016/j.critrevonc.2017.08.005_bib0560 article-title: Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment publication-title: BJU Int. doi: 10.1111/j.1464-410X.2010.09716.x – volume: 23 start-page: S48 issue: 1 year: 2015 ident: 10.1016/j.critrevonc.2017.08.005_bib0490 article-title: Efficacy and safety and tolerability of fulranumab as adjunctive therapy for cancer-related pain: a randomized, double-blind, placebo-controlled, multicenter study publication-title: Support. Care Cancer – volume: 25 start-page: 4868 year: 2005 ident: 10.1016/j.critrevonc.2017.08.005_bib0150 article-title: trkA is expressed in nociceptive neurons and influences electrophysiological properties via Nav1: 8 expression in rapidly conducting nociceptors publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0249-05.2005 – volume: 36 start-page: 2631 year: 2016 ident: 10.1016/j.critrevonc.2017.08.005_bib0265 article-title: Management of metastatic bone disease algorithms for diagnostic and treatment publication-title: Anticancer Res. – volume: 23 start-page: S8 year: 2015 ident: 10.1016/j.critrevonc.2017.08.005_bib0475 article-title: A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee publication-title: Osteoarthritis Cartilage doi: 10.1016/j.joca.2014.10.003 – volume: 21 start-page: 4277 year: 2003 ident: 10.1016/j.critrevonc.2017.08.005_bib0495 article-title: Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2003.05.147 – volume: 21 start-page: 3497 year: 2011 ident: 10.1016/j.critrevonc.2017.08.005_bib0545 article-title: Pain and health-related quality of life in patients with advanced solid tumours and bone metastases: integrated results from three randomized, double-blind studies of denosumab and zoledronic acid publication-title: Support. Care Cancer doi: 10.1007/s00520-013-1932-2 – volume: 92 start-page: 1869 year: 2005 ident: 10.1016/j.critrevonc.2017.08.005_bib0555 article-title: Zoledronic acid significant- ly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6602551 – volume: 8 start-page: 83 issue: 2 year: 2014 ident: 10.1016/j.critrevonc.2017.08.005_bib0345 article-title: Bone cancer pain: from mechanism to therapy publication-title: Curr. Opin. Support Palliat Care doi: 10.1097/SPC.0000000000000048 – volume: 15:12 start-page: 6243s issue: 20 year: 2006 ident: 10.1016/j.critrevonc.2017.08.005_bib0090 article-title: Clinical features of metastatic bone disease and risk of skeletal morbidity publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-06-0931 – volume: 129 start-page: 389 year: 2000 ident: 10.1016/j.critrevonc.2017.08.005_bib0220 article-title: Cellular and neurochemical remodeling of the spinal cord in bone cancer pain publication-title: Prog. Brain Res. doi: 10.1016/S0079-6123(00)29030-4 – start-page: 1 year: 2016 ident: 10.1016/j.critrevonc.2017.08.005_bib0445 article-title: Evidence on the analgesic role of bisphosphonates and denosumab in the treatment of pain due to bone metastases: a systematic review within the European Association for Palliative Care guidelines project publication-title: Pall Med. – volume: 152 start-page: 2564 year: 2011 ident: 10.1016/j.critrevonc.2017.08.005_bib0280 article-title: Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain publication-title: Pain doi: 10.1016/j.pain.2011.07.020 – volume: 289 start-page: 1271 year: 1999 ident: 10.1016/j.critrevonc.2017.08.005_bib0435 article-title: Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat publication-title: J. Pharmacol. Exp. Ther. doi: 10.1016/S0022-3565(24)38269-2 – volume: 28 start-page: 279 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0160 article-title: Low affinity NGF receptor (p75 neurotrophin receptor) inhibitory antibody reduces pain behavior and CGRP expression in DRG in the mouse sciatic nerve crush model publication-title: J. Orthop. Res. doi: 10.1002/jor.20986 – volume: 171 start-page: 588 issue: 2 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0360 article-title: Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.08.056 – volume: 1 start-page: 19 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0315 article-title: Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567 publication-title: ACS Chem. Neurosci. doi: 10.1021/cn9000186 – volume: 132 start-page: 132 issue: 1-2 year: 2007 ident: 10.1016/j.critrevonc.2017.08.005_bib0065 article-title: The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans publication-title: Pain doi: 10.1016/j.pain.2007.06.006 – volume: 7 start-page: 157 year: 2016 ident: 10.1016/j.critrevonc.2017.08.005_bib0415 article-title: The physiology of bone pain. How much do we really know? publication-title: Front. Physiol. doi: 10.3389/fphys.2016.00157 – volume: 17 start-page: 846 year: 1999 ident: 10.1016/j.critrevonc.2017.08.005_bib0520 article-title: Pamidronate reduces skeletal mor- bidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer study group publication-title: J. Clin. Oncol. doi: 10.1200/JCO.1999.17.3.846 – volume: 9 start-page: 72 year: 2011 ident: 10.1016/j.critrevonc.2017.08.005_bib0370 article-title: Estimating minimally important differences for the worst pain rating of the brief pain inventory-short form publication-title: J. Support Oncol. doi: 10.1016/j.suponc.2010.12.004 – volume: 36 start-page: 57 year: 2002 ident: 10.1016/j.critrevonc.2017.08.005_bib0270 article-title: p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia publication-title: Neuron doi: 10.1016/S0896-6273(02)00908-X – volume: 28 start-page: 5132 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0515 article-title: Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2010.29.7101 – volume: 14 start-page: 1399 year: 2003 ident: 10.1016/j.critrevonc.2017.08.005_bib0040 article-title: Intravenous ibandronate reduces the incidence of skeletal complica- tions in patients with breast cancer and bone metastases publication-title: Ann. Oncol. doi: 10.1093/annonc/mdg367 – volume: 17 start-page: 4989 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0255 article-title: Increased nerve growth factor in neurogenic overactive bladder and interstitial cystitis patients publication-title: Can. J. Urol. – volume: 63 start-page: 65 year: 1995 ident: 10.1016/j.critrevonc.2017.08.005_bib0585 article-title: Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study publication-title: Pain doi: 10.1016/0304-3959(95)00017-M – volume: 22 start-page: 587 year: 2006 ident: 10.1016/j.critrevonc.2017.08.005_bib0195 article-title: Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer publication-title: Clin. J. Pain doi: 10.1097/01.ajp.0000210902.67849.e6 – volume: 36 start-page: 3204 year: 2012 ident: 10.1016/j.critrevonc.2017.08.005_bib0185 article-title: Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2012.08235.x – volume: 157 start-page: 2057 issue: 9 year: 2016 ident: 10.1016/j.critrevonc.2017.08.005_bib0010 article-title: A randomized, double blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist 8V116517) in healthy volunteers and comparison with preclinical profile publication-title: Pain doi: 10.1097/j.pain.0000000000000610 – year: 2012 ident: 10.1016/j.critrevonc.2017.08.005_bib0135 article-title: The role of purinergic receptors in cancer-induced bone pain publication-title: J. Osteoporos. doi: 10.1155/2012/758181 – volume: 29 start-page: 1125 year: 2011 ident: 10.1016/j.critrevonc.2017.08.005_bib0210 article-title: Randomized, double-blind study of denosumab versus zole- dronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2010.31.3304 – volume: 23 start-page: 919 year: 1998 ident: 10.1016/j.critrevonc.2017.08.005_bib0190 article-title: Elevated nerve growth factor levels in the synovial fluid of patients with inflammatory joint disease publication-title: Neurochem. Res. doi: 10.1023/A:1022475432077 – volume: 368 start-page: 246 year: 1994 ident: 10.1016/j.critrevonc.2017.08.005_bib0500 article-title: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene publication-title: Nature doi: 10.1038/368246a0 – volume: 2 start-page: 201 year: 2002 ident: 10.1016/j.critrevonc.2017.08.005_bib0350 article-title: Molecular mechanisms of cancer pain publication-title: Nat. Rev. Cancer doi: 10.1038/nrc747 – volume: l8 start-page: 148 year: 2012 ident: 10.1016/j.critrevonc.2017.08.005_bib0145 article-title: Weighing bone-targeted treatment options for patients with solid tumours and skeletal complications from metastatic disease publication-title: Eur. Oncol. Haematol. doi: 10.17925/EOH.2012.08.3.148 – volume: 7 start-page: 797 issue: 10 year: 2006 ident: 10.1016/j.critrevonc.2017.08.005_bib0365 article-title: Cancer pain and its impact on diagnosis, survival and quality of life publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn1914 – volume: 2 start-page: 687 year: 2003 ident: 10.1016/j.critrevonc.2017.08.005_bib0250 article-title: Complex regional pain syndrome: mystery explained publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(03)00557-X – volume: 12 start-page: 1433 year: 2001 ident: 10.1016/j.critrevonc.2017.08.005_bib0260 article-title: Comparison of the effects of intravenous pamidronate and oral clodronate on symptoms and bone resorption in patients with metastatic bone disease publication-title: Ann. Oncol. doi: 10.1023/A:1012506426440 – volume: 65 start-page: 189 year: 1991 ident: 10.1016/j.critrevonc.2017.08.005_bib0305 article-title: The trk proto-oncogene encodes a receptor for nerve growth factor publication-title: Cell doi: 10.1016/0092-8674(91)90419-Y – volume: 46 start-page: 306 issue: 2 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0275 article-title: A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain publication-title: Bone doi: 10.1016/j.bone.2009.09.013 – volume: 2 start-page: CD002068 year: 2002 ident: 10.1016/j.critrevonc.2017.08.005_bib0580 article-title: Bisphosphonates for the relief of pain secondary to bone metastases publication-title: Cochrane Database Syst. Rev. – volume: 79 start-page: 243 year: 2004 ident: 10.1016/j.critrevonc.2017.08.005_bib0540 article-title: Bone cancer pain model in mice: evaluation of pain behavior, bone destruction and morphine sensitivity publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/j.pbb.2004.07.011 – volume: 87 start-page: 30 year: 2007 ident: 10.1016/j.critrevonc.2017.08.005_bib0120 article-title: The impact of the opioids fentanyl and morphine on nociception and bone destruction in a murine model of bone cancer pain publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/j.pbb.2007.03.017 – volume: 23 start-page: vii39 issue: S7 year: 2012 ident: 10.1016/j.critrevonc.2017.08.005_bib0465 article-title: Management of cancer pain: ESMO clinical practice guidelines publication-title: Ann. Oncol. – volume: 18 start-page: 1437 year: 2007 ident: 10.1016/j.critrevonc.2017.08.005_bib0535 article-title: Prevalence of pain in patients with cancer: a systematic review of the past 40 years publication-title: Ann. Oncol. doi: 10.1093/annonc/mdm056 – volume: 373 start-page: 104 year: 2000 ident: 10.1016/j.critrevonc.2017.08.005_bib0085 article-title: Review of cellular mechanisms of tumor osteolysis publication-title: Clin. Orthop. Relat. Res. doi: 10.1097/00003086-200004000-00013 – volume: 517 start-page: 276 year: 2009 ident: 10.1016/j.critrevonc.2017.08.005_bib0240 article-title: Size, neurochemistry, and segmental distribution of sensory neurons innervating the rat tibia publication-title: J. Comp. Neurol. doi: 10.1002/cne.22160 – volume: 171 start-page: 588 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0355 article-title: Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.08.056 – volume: 18 start-page: 29 year: 1996 ident: 10.1016/j.critrevonc.2017.08.005_bib0200 article-title: Immunohistochemical and ultrastructural localization of CGRP-positive nerve fibers at the epiphyseal trabecules facing the growth plate of rat femurs publication-title: Bone doi: 10.1016/8756-3282(95)00425-4 – volume: 42 start-page: 1504 year: 2009 ident: 10.1016/j.critrevonc.2017.08.005_bib0320 article-title: Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus publication-title: Clin. Biochem. doi: 10.1016/j.clinbiochem.2009.06.017 – volume: 33 start-page: 1 year: 2015 ident: 10.1016/j.critrevonc.2017.08.005_bib0015 article-title: Randomized trial of low-dose morphine versus weak opioids in moderate cancer pain publication-title: J. Clin. Oncol. – volume: 12 start-page: 268 year: 2002 ident: 10.1016/j.critrevonc.2017.08.005_bib0180 article-title: Retrograde neurotrophin signaling: trk-ing along the axon publication-title: Curr. Opin. Neurobiol. doi: 10.1016/S0959-4388(02)00326-4 – volume: 411 start-page: 957 year: 2001 ident: 10.1016/j.critrevonc.2017.08.005_bib0070 article-title: Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition publication-title: Nature doi: 10.1038/35082088 – volume: 413 start-page: 203 issue: 6852 year: 2001 ident: 10.1016/j.critrevonc.2017.08.005_bib0290 article-title: Molecular mechanisms of nociception publication-title: Nature doi: 10.1038/35093019 – volume: 26 start-page: 305 year: 2012 ident: 10.1016/j.critrevonc.2017.08.005_bib0410 article-title: The role of paracetamol and non steroideal anti-inflammatory drugs in addition to WHO step III opioids in the control of pain in advanced cancer. A systematic review of te literature publication-title: Palliat. Med. doi: 10.1177/0269216311428528 – volume: 45 start-page: 17 issue: 1 year: 2005 ident: 10.1016/j.critrevonc.2017.08.005_bib0590 article-title: Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd publication-title: Neuron doi: 10.1016/j.neuron.2004.12.015 – volume: 106 start-page: 1681 year: 2010 ident: 10.1016/j.critrevonc.2017.08.005_bib0325 article-title: Urinary nerve growth factor but not prostaglandin E2 increases in patients with interstitial cystitis/bladder pain syndrome and detrusor overactivity publication-title: BJU Int. doi: 10.1111/j.1464-410X.2009.08851.x – volume: 16 start-page: 2038 year: 1998 ident: 10.1016/j.critrevonc.2017.08.005_bib0235 article-title: Long-term prevention of skeletal complications of metastatic breast cancer with pamidronate: protocol 19 Aredia Breast Cancer study group publication-title: J. Clin. Oncol. doi: 10.1200/JCO.1998.16.6.2038 – volume: 12 start-page: 6243 issue: 20 Pt 2 year: 2006 ident: 10.1016/j.critrevonc.2017.08.005_bib0095 article-title: Clinical features of metastatic bone disease and risk of skeletal morbidity publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-06-0931 |
| SSID | ssj0004467 |
| Score | 2.326073 |
| SecondaryResourceType | review_article |
| Snippet | •About 75% of patients with bone involvement is interested by pain.•Cancer-related bone pain has both a nociceptive and a neuropathic component.•Cancer-related... Cancer-related bone pain is a frequent and important key problem for metastatic patients that may reduce quality of life, with related limitations in daily... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 66 |
| SubjectTerms | Analgesics, Opioid - pharmacology Analgesics, Opioid - therapeutic use Bone metastases Bone Neoplasms - physiopathology Bone Neoplasms - secondary Cancer pain Cancer Pain - drug therapy Humans Nerve growth factor Opioids Quality of Life Randomized Controlled Trials as Topic RANK RANK-L |
| Title | Developing drugs in cancer-related bone pain |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S1040842817302202 https://dx.doi.org/10.1016/j.critrevonc.2017.08.005 https://www.ncbi.nlm.nih.gov/pubmed/28893462 https://www.proquest.com/docview/1938194511 |
| Volume | 119 |
| WOSCitedRecordID | wos000415392100009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1879-0461 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0004467 issn: 1040-8428 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3da9RAEF-0FfFF6vdpLRF8NJKPzW6CT4e2VtEiWuHewmaTLSmSHLmLlPz1zuxuNj1q4Yr4EkKOyeZmJvOxmfkNIa9jESRFkFSQlgjh00yWYAdl6ldRyRgNVVKUVA-b4Ccn6WKRfbNf8Fd6nABvmvTiIlv-V1HDNRA2ts7eQNzupnABzkHocASxw3ErwX-Y2qDKrj_T9a4SZdv5unEFQ84WQsulsKDbI07BOPTAApQiXdtI281ypMFdN_bgv_QSp23VpuWn7-rB1HQZHMcGi4h0ZPpRVBCBup_mOLW4H4bW1VM6z_C9HYbaQhqArWkvb0mAmws3tiSu9spo04q1iym1reCj7bX20lhPxi75YTO854qFN5sN52_Bpq6BH8AHrM_jGoc1SCav5moNf-DCuG4IxiyKEHh0N-JJBiZwd_7pcPF5aqOleuCwe1Bb-GXKAf--3nXRzHXZio5aTvfIfZtueHOjJg_Irap5SO5-tQUVj8ibSVs8rS1e3Xib2uKhtnioLY_Jz6PD0_fHvh2g4UuIC9c-y2jBilgoniAuXxYIlUmVhZGCN7dUlRI8YJDvhpKDHRe0VGUoq4KBDyi4Sqr4CdlpYI1nxAviuOSKy0CIlMowFlzEjGKnWJqUQDsjfGRELi26PA45-ZWPZYTn-cTCHFmY4_zTIJmR0FEuDcLKFjTZyOt87CAGn5eDkmxB-87R2ijTRI9bUr8aRZuDIcava6Kp2n6VQyYE0TXC_c3IUyNz93-iFNICyqLn__DcL8i96V3bJzvrrq9ekjvy97pedQfkNl-kB1aj_wBK4r47 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Developing+drugs+in+cancer-related+bone+pain&rft.jtitle=Critical+reviews+in+oncology%2Fhematology&rft.au=Lucchesi%2C+Maurizio&rft.au=Lanzetta%2C+Gaetano&rft.au=Antonuzzo%2C+Andrea&rft.au=Rozzi%2C+Antonio&rft.date=2017-11-01&rft.pub=Elsevier+B.V&rft.issn=1040-8428&rft.volume=119&rft.spage=66&rft.epage=74&rft_id=info:doi/10.1016%2Fj.critrevonc.2017.08.005&rft.externalDocID=S1040842817302202 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1040-8428&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1040-8428&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1040-8428&client=summon |