Time trial performance in normal and high ambient temperature: is there a role for 5-HT?

The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyc...

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Vydané v:European journal of applied physiology Ročník 107; číslo 1; s. 119 - 126
Hlavní autori: Roelands, Bart, Goekint, Maaike, Buyse, Luk, Pauwels, Frank, De Schutter, Guy, Piacentini, Francesca, Hasegawa, Hiroshi, Watson, Phil, Meeusen, Romain
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Berlin/Heidelberg Springer-Verlag 01.09.2009
Springer
Springer Nature B.V
Predmet:
Adaptation, Physiological - physiology
Adult
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Exercise
Fatigue
Fundamental and applied biological sciences. Psychology
Heart rate
Heat
Heat-Shock Response - physiology
Human Physiology
Humans
Hypotheses
Male
Metabolism
Muscle Fatigue - physiology
Occupational Medicine/Industrial Medicine
Original Article
Physiology
Psychomotor Performance - physiology
Serotonin - blood
Sports Medicine
Temperature
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
Central fatigue
Heat
Exercise
Serotonin
Citalopram
Physical exercise
Human
Temperature
Central fatigues
Physical performance
Neurotransmitter
Environmental factor
Fatigue
ISSN:1439-6319, 1439-6327, 1439-6327
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Abstract The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyclists completed four experimental trials (two in 18°C, two in 30°C) in a double-blind randomised crossover design. Subjects ingested either a placebo (PLA: lactose 2 × 10 mg) or citalopram (CITAL 2 × 10 mg) on the evening before and the morning of the trial. Subjects cycled for 60 min at 55% W max , immediately followed by a time trial (TT) to measure performance. The significance level was set at P  < 0.05. Acute SSRI did not significantly change performance on the TT (18°C P  = 0.518; 30°C P  = 0.112). During recovery at 30°C, core temperature was significantly lower in the CITAL trial ( P  < 0.012). At 30°C heart rate was significantly lower after exercise in CITAL ( P  = 0.013). CITAL significantly increased cortisol concentrations at rest ( P  = 0.016), after the TT ( P  = 0.006) and after 15-min recovery ( P  = 0.041) at 30°C. 5-HT reuptake inhibition did not cause significant reductions in performance. Core temperature was significantly lower only after the time trial in heat after CITAL administration. The present work failed to prove whether or not 5-HT has an exclusive role in the onset of centrally mediated fatigue during prolonged exercise in both normal and high ambient temperature.
AbstractList The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyclists completed four experimental trials (two in 18°C, two in 30°C) in a double-blind randomised crossover design. Subjects ingested either a placebo (PLA: lactose 2 × 10 mg) or citalopram (CITAL 2 × 10 mg) on the evening before and the morning of the trial. Subjects cycled for 60 min at 55% W max , immediately followed by a time trial (TT) to measure performance. The significance level was set at P  < 0.05. Acute SSRI did not significantly change performance on the TT (18°C P  = 0.518; 30°C P  = 0.112). During recovery at 30°C, core temperature was significantly lower in the CITAL trial ( P  < 0.012). At 30°C heart rate was significantly lower after exercise in CITAL ( P  = 0.013). CITAL significantly increased cortisol concentrations at rest ( P  = 0.016), after the TT ( P  = 0.006) and after 15-min recovery ( P  = 0.041) at 30°C. 5-HT reuptake inhibition did not cause significant reductions in performance. Core temperature was significantly lower only after the time trial in heat after CITAL administration. The present work failed to prove whether or not 5-HT has an exclusive role in the onset of centrally mediated fatigue during prolonged exercise in both normal and high ambient temperature.
The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyclists completed four experimental trials (two in 18°C, two in 30°C) in a double-blind randomised crossover design. Subjects ingested either a placebo (PLA: lactose 2 × 10 mg) or citalopram (CITAL 2 × 10 mg) on the evening before and the morning of the trial. Subjects cycled for 60 min at 55% W max, immediately followed by a time trial (TT) to measure performance. The significance level was set at P < 0.05. Acute SSRI did not significantly change performance on the TT (18°C P = 0.518; 30°C P = 0.112). During recovery at 30°C, core temperature was significantly lower in the CITAL trial (P < 0.012). At 30°C heart rate was significantly lower after exercise in CITAL (P = 0.013). CITAL significantly increased cortisol concentrations at rest (P = 0.016), after the TT (P = 0.006) and after 15-min recovery (P = 0.041) at 30°C. 5-HT reuptake inhibition did not cause significant reductions in performance. Core temperature was significantly lower only after the time trial in heat after CITAL administration. The present work failed to prove whether or not 5-HT has an exclusive role in the onset of centrally mediated fatigue during prolonged exercise in both normal and high ambient temperature.
The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyclists completed four experimental trials (two in 18 degree C, two in 30 degree C) in a double-blind randomised crossover design. Subjects ingested either a placebo (PLA: lactose 210mg) or citalopram (CITAL 210mg) on the evening before and the morning of the trial. Subjects cycled for 60min at 55% W sub(max), immediately followed by a time trial (TT) to measure performance. The significance level was set at P<0.05. Acute SSRI did not significantly change performance on the TT (18 degree C P=0.518; 30 degree C P=0.112). During recovery at 30 degree C, core temperature was significantly lower in the CITAL trial (P<0.012). At 30 degree C heart rate was significantly lower after exercise in CITAL (P=0.013). CITAL significantly increased cortisol concentrations at rest (P=0.016), after the TT (P=0.006) and after 15-min recovery (P=0.041) at 30 degree C. 5-HT reuptake inhibition did not cause significant reductions in performance. Core temperature was significantly lower only after the time trial in heat after CITAL administration. The present work failed to prove whether or not 5-HT has an exclusive role in the onset of centrally mediated fatigue during prolonged exercise in both normal and high ambient temperature.
The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyclists completed four experimental trials (two in 18 degrees C, two in 30 degrees C) in a double-blind randomised crossover design. Subjects ingested either a placebo (PLA: lactose 2 x 10 mg) or citalopram (CITAL 2 x 10 mg) on the evening before and the morning of the trial. Subjects cycled for 60 min at 55% W(max), immediately followed by a time trial (TT) to measure performance. The significance level was set at P < 0.05. Acute SSRI did not significantly change performance on the TT (18 degrees C P = 0.518; 30 degrees C P = 0.112). During recovery at 30 degrees C, core temperature was significantly lower in the CITAL trial (P < 0.012). At 30 degrees C heart rate was significantly lower after exercise in CITAL (P = 0.013). CITAL significantly increased cortisol concentrations at rest (P = 0.016), after the TT (P = 0.006) and after 15-min recovery (P = 0.041) at 30 degrees C. 5-HT reuptake inhibition did not cause significant reductions in performance. Core temperature was significantly lower only after the time trial in heat after CITAL administration. The present work failed to prove whether or not 5-HT has an exclusive role in the onset of centrally mediated fatigue during prolonged exercise in both normal and high ambient temperature.The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyclists completed four experimental trials (two in 18 degrees C, two in 30 degrees C) in a double-blind randomised crossover design. Subjects ingested either a placebo (PLA: lactose 2 x 10 mg) or citalopram (CITAL 2 x 10 mg) on the evening before and the morning of the trial. Subjects cycled for 60 min at 55% W(max), immediately followed by a time trial (TT) to measure performance. The significance level was set at P < 0.05. Acute SSRI did not significantly change performance on the TT (18 degrees C P = 0.518; 30 degrees C P = 0.112). During recovery at 30 degrees C, core temperature was significantly lower in the CITAL trial (P < 0.012). At 30 degrees C heart rate was significantly lower after exercise in CITAL (P = 0.013). CITAL significantly increased cortisol concentrations at rest (P = 0.016), after the TT (P = 0.006) and after 15-min recovery (P = 0.041) at 30 degrees C. 5-HT reuptake inhibition did not cause significant reductions in performance. Core temperature was significantly lower only after the time trial in heat after CITAL administration. The present work failed to prove whether or not 5-HT has an exclusive role in the onset of centrally mediated fatigue during prolonged exercise in both normal and high ambient temperature.
The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyclists completed four experimental trials (two in 18 degrees C, two in 30 degrees C) in a double-blind randomised crossover design. Subjects ingested either a placebo (PLA: lactose 2 x 10 mg) or citalopram (CITAL 2 x 10 mg) on the evening before and the morning of the trial. Subjects cycled for 60 min at 55% W(max), immediately followed by a time trial (TT) to measure performance. The significance level was set at P < 0.05. Acute SSRI did not significantly change performance on the TT (18 degrees C P = 0.518; 30 degrees C P = 0.112). During recovery at 30 degrees C, core temperature was significantly lower in the CITAL trial (P < 0.012). At 30 degrees C heart rate was significantly lower after exercise in CITAL (P = 0.013). CITAL significantly increased cortisol concentrations at rest (P = 0.016), after the TT (P = 0.006) and after 15-min recovery (P = 0.041) at 30 degrees C. 5-HT reuptake inhibition did not cause significant reductions in performance. Core temperature was significantly lower only after the time trial in heat after CITAL administration. The present work failed to prove whether or not 5-HT has an exclusive role in the onset of centrally mediated fatigue during prolonged exercise in both normal and high ambient temperature.
Author Goekint, Maaike
Buyse, Luk
Roelands, Bart
Hasegawa, Hiroshi
Pauwels, Frank
Meeusen, Romain
De Schutter, Guy
Piacentini, Francesca
Watson, Phil
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  surname: Roelands
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  organization: Department Human Physiology and Sports Medicine, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel
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  surname: Buyse
  fullname: Buyse, Luk
  organization: Department Human Physiology and Sports Medicine, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel
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ISSN 1439-6319
1439-6327
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IsPeerReviewed true
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Issue 1
Keywords Central fatigue
Heat
Exercise
Serotonin
Citalopram
Physical exercise
Human
Temperature
Central fatigues
Physical performance
Neurotransmitter
Environmental factor
Fatigue
Language English
License http://www.springer.com/tdm
CC BY 4.0
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crossref_citationtrail_10_1007_s00421_009_1109_3
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PublicationCentury 2000
PublicationDate 2009-09-01
PublicationDateYYYYMMDD 2009-09-01
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PublicationDecade 2000
PublicationPlace Berlin/Heidelberg
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PublicationTitle European journal of applied physiology
PublicationTitleAbbrev Eur J Appl Physiol
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PublicationYear 2009
Publisher Springer-Verlag
Springer
Springer Nature B.V
Publisher_xml – name: Springer-Verlag
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DavisJBaileySPossible mechanisms of central nervous system fatigue during exerciseMed Sci Sports Exerc1997291455790001551:CAS:528:DyaK2sXotlWqsQ%3D%3D
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BaileySDavisJAhlbornESerotonergic agonists and antagonists affect endurance performance in the ratInt J Sports Med1993146330333840706310.1055/s-2007-10211871:CAS:528:DyaK2cXpsFGgtg%3D%3D
HillegaartVEffects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on core temperature in the ratPsychopharmacology1991103291296182923510.1007/BF022442811:CAS:528:DyaK3MXhtlKlsr4%3D
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Allott K, Canny B, Broadbear J, Stepto N, Murphy B, Redman J (2008) Neuroendocrine and subjective responses to pharmacological challenge with citalopram: a controlled study in male and female ecstacy/MDMA users. J Psychopharmacology. doi:10.1177/0269881108092336 (E-Pub)
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OotsukaYBlessingWThermogenesis in brown adipose tissue: increase by 5-HT2A receptor activation and decrease by 5-HT1A receptor activation in conscious ratsNeurosci Lett20063951701741629336510.1016/j.neulet.2005.10.0621:CAS:528:DC%2BD28XhtValt7o%3D
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RoelandsBHasegawaHWatsonPPiacentiniMBuyseLDe SchutterGMeeusenRPerformance and thermoregulatory effects of chronic bupropion administration in the heatEur J Appl Physiol20091054934981900270210.1007/s00421-008-0929-x1:CAS:528:DC%2BD1MXotVGlsw%3D%3D
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L Kar Van de (1109_CR35) 1997
T Wilckens (1109_CR37) 1992; 43
J Davis (1109_CR9) 1997; 29
S Bailey (1109_CR3) 1993; 14
R Meeusen (1109_CR17) 2006; 36
F Chaouloff (1109_CR6) 1987; 26
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References_xml – reference: RoelandsBHasegawaHWatsonPBuyseLDe SchutterGPiacentiniMFMeeusenRThe effects of acute dopamine reuptake inhibition on performanceMed Sci Sports Exerc20084058798851840861010.1249/MSS.0b013e3181659c4d1:CAS:528:DC%2BD1cXkslejsLg%3D
– reference: JeukendrupASarisWHBrounsFKesterADA new validated endurance performance testMed Sci Sports Exerc19962826627087751641:STN:280:DyaK28zntFehuw%3D%3D
– reference: LinMTsayHSuWChuefFChanges in extracellular serotonin in rat hypothalamus affect thermoregulatory functionAm J Physiol19982745 Pt 2R1260R126796440381:CAS:528:DyaK1cXjsV2jsb8%3D
– reference: DavisJBaileySPossible mechanisms of central nervous system fatigue during exerciseMed Sci Sports Exerc1997291455790001551:CAS:528:DyaK2sXotlWqsQ%3D%3D
– reference: NyboLNielsenBBlomstrandEMøllerKSecherNHNeurohumoral responses during prolonged exercise in humansJ Appl Physiol20039511251131127541711:CAS:528:DC%2BD3sXnsFCjtrw%3D
– reference: RittenhousePLevyALiQBetheaCVan de KarLNeurons in the hypothalamic paraventricular nucleus mediate the serotonergic stimulation of prolactin secretion via 5-HT1c/2 receptorsEndocrinology1993133661667834420510.1210/en.133.2.6611:CAS:528:DyaK3sXlvFKns7k%3D
– reference: MeeusenRWatsonPHasegawaHRoelandsBPiacentiniMFCentral fatigue: the serotonin hypothesis and beyondSports Med200636108819091700485010.2165/00007256-200636100-00006
– reference: PannierJBouckaertJLefebvreRThe antiserotonin agent pizotifen does not increase endurance performance in humansEur J Appl Physiol Occup Physiol1995721–2175178878959010.1007/BF009641341:CAS:528:DyaK28XmsFyitrs%3D
– reference: WatsonPHasegawaHRoelandsBPiacentiniMFLoovrieRMeeusenRAcute dopamine/noradrenaline reuptake inhibition enhances human exercise performance in warm, but not temperate conditionsJ Physiol2005565.387388310.1113/jphysiol.2004.079202
– reference: WilckensTSchweigerUPirkeKActivation of alpha 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive ratPharmacol Biochem Behav1992433733738136016110.1016/0091-3057(92)90402-21:CAS:528:DyaK38XmsVGqtL8%3D
– reference: RaapDVan de KarLMinireview: selective serotonin reuptake inhibitors and neuroendocrine functionLife Sci199965121712351050393810.1016/S0024-3205(99)00169-11:CAS:528:DyaK1MXls12gs7Y%3D
– reference: BaileySDavisJAhlbornEEffect of increased brain serotonergic activity on endurance performance in the ratActa Physiol Scand199214517576150291610.1111/j.1748-1716.1992.tb09338.x1:CAS:528:DyaK38Xks1els70%3D
– reference: MeeusenRRoeykensJMagnusLKeizerHDe MeirleirKEndurance performance in humans: the effect of a dopamine precursor or a specific serotonin (5-HT2A/2C) antagonistInt J Sports Med199718571577944358710.1055/s-2007-9726831:CAS:528:DyaK2sXnvFynsLo%3D
– reference: MeeusenRPiacentiniMFVan Den EyndeSMagnusLDe MeirleirKExercise performance is not influenced by a 5-HT reuptake inhibitorInt J Sports Med2001223293361151086810.1055/s-2001-156481:CAS:528:DC%2BD3MXmtVSgtbg%3D
– reference: BorgGAPsychophysical bases of perceived exertionMed Sci Sports Exerc19821437738171548931:STN:280:DyaL3s7hsVChsw%3D%3D
– reference: CoxBKerwinRLeeTPycockA dopaminergic-5-hydroxytriptamine link in the hypothalamic pathways which mediates heat loss in the ratJ Physiol Paris19803039211:CAS:528:DyaL3cXks1aju78%3D
– reference: NadeemHAttenburrowMCowenPComparison of the effects of citalopram and escitalopram on 5-HT-mediated neuroendocrine responsesNeuropsychopharmacology200429169917031512708210.1038/sj.npp.13004751:CAS:528:DC%2BD2cXmvVOqsLY%3D
– reference: NyboLNielsenBHyperthermia and central fatigue during prolonged exercise in the heatJ Appl Physiol20019110551060115094981:STN:280:DC%2BD3MvmsVKmtA%3D%3D
– reference: OotsukaYBlessingWThermogenesis in brown adipose tissue: increase by 5-HT2A receptor activation and decrease by 5-HT1A receptor activation in conscious ratsNeurosci Lett20063951701741629336510.1016/j.neulet.2005.10.0621:CAS:528:DC%2BD28XhtValt7o%3D
– reference: RoelandsBGoekintMHeymanEPiacentiniMWatsonPHasegawaHBuyseLPauwelsFDe SchutterGMeeusenRAcute norepinephrine reuptake inhibition decreases performance in normal and high ambient temperatureJ Appl Physiol200810512062121849977710.1152/japplphysiol.90509.20081:CAS:528:DC%2BD1cXps12htLo%3D
– reference: StrachanALeiperJMaughanRThe failure of acute paroxetine administration to influence human exercise capacity, RPE or hormone responses during prolonged exercise in a warm environmentExp Physiol20048966576641532830610.1113/expphysiol.2004.0278391:CAS:528:DC%2BD2cXhtFWqtrjI
– reference: Van de KarLBaumgartenHGGothertM5-HT receptors involved in the regulation of hormone secretionSerotonergic neurons and 5-HT receptors in the CNS1997New YorkSpringer557562
– reference: HillegaartVEffects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on core temperature in the ratPsychopharmacology1991103291296182923510.1007/BF022442811:CAS:528:DyaK3MXhtlKlsr4%3D
– reference: BaileySDavisJAhlbornESerotonergic agonists and antagonists affect endurance performance in the ratInt J Sports Med1993146330333840706310.1055/s-2007-10211871:CAS:528:DyaK2cXpsFGgtg%3D%3D
– reference: MajJBijakMDziedzicka-WasylewskaMRogozRRogozZSkuzaGTokarskiTThe effects of paroxetine given repeatedly on the responsiveness of 5-HT subpopulations in the rat brainPsychopharmacology (Berlin)1996127738210.1007/BF028059771:CAS:528:DyaK28Xlslanu7w%3D
– reference: Allott K, Canny B, Broadbear J, Stepto N, Murphy B, Redman J (2008) Neuroendocrine and subjective responses to pharmacological challenge with citalopram: a controlled study in male and female ecstacy/MDMA users. J Psychopharmacology. doi:10.1177/0269881108092336 (E-Pub)
– reference: StrüderHHollmannWPlatenPDonikeMGotzmannAWeberKInfluence of paroxetine, branched-chain amino acids and tyrosine on neuroendocrine system responses and fatigue in humansHorm Metab Res199830188194962363210.1055/s-2007-978864
– reference: RadomskiMCrossMBuguetAExercise-induced hyperthermia and hormonal responses to exerciseCan J Physiol Pharmacol1998765547552983908110.1139/cjpp-76-5-5471:CAS:528:DyaK1cXnsVKlsrc%3D
– reference: Ben-JonathanNDopamine: a prolactin-inhibiting hormoneEndocr Rev19856564589286695210.1210/edrv-6-4-5641:CAS:528:DyaL28Xot1SltA%3D%3D
– reference: WilsonWMaughanREvidence for a possible role of 5-hydroxytryptamine in the genesis of fatigue in man: administration of paroxetine, a 5-HT re-uptake inhibitor, reduces the capacity to perform prolonged exerciseExp Physiol19927792192414895481:CAS:528:DyaK3sXhtFOhtbk%3D
– reference: ChaouloffFLaudeDMerinoDSerrurierBGuezennecYElghoziJLAmphetamine, and [alpha]-methyl-p-tyrosine affect the exercise induced imbalance between the availability of tryptophan and synthesis of serotonin in the brain of the ratNeuropharmacology19872610991106244387010.1016/0028-3908(87)90254-11:CAS:528:DyaL2sXltV2qsr8%3D
– reference: RoelandsBHasegawaHWatsonPPiacentiniMBuyseLDe SchutterGMeeusenRPerformance and thermoregulatory effects of chronic bupropion administration in the heatEur J Appl Physiol20091054934981900270210.1007/s00421-008-0929-x1:CAS:528:DC%2BD1MXotVGlsw%3D%3D
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Snippet The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the...
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StartPage 119
SubjectTerms Adaptation, Physiological - physiology
Adult
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Exercise
Fatigue
Fundamental and applied biological sciences. Psychology
Heart rate
Heat
Heat-Shock Response - physiology
Human Physiology
Humans
Hypotheses
Male
Metabolism
Muscle Fatigue - physiology
Occupational Medicine/Industrial Medicine
Original Article
Physiology
Psychomotor Performance - physiology
Serotonin - blood
Sports Medicine
Temperature
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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Title Time trial performance in normal and high ambient temperature: is there a role for 5-HT?
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