Time trial performance in normal and high ambient temperature: is there a role for 5-HT?

The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyc...

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Veröffentlicht in:	European journal of applied physiology Jg. 107; H. 1; S. 119 - 126
Hauptverfasser:	Roelands, Bart, Goekint, Maaike, Buyse, Luk, Pauwels, Frank, De Schutter, Guy, Piacentini, Francesca, Hasegawa, Hiroshi, Watson, Phil, Meeusen, Romain
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Berlin/Heidelberg Springer-Verlag 01.09.2009 Springer Springer Nature B.V
Schlagworte:	Adaptation, Physiological - physiology Adult Biological and medical sciences Biomedical and Life Sciences Biomedicine Exercise Fatigue Fundamental and applied biological sciences. Psychology Heart rate Heat Heat-Shock Response - physiology Human Physiology Humans Hypotheses Male Metabolism Muscle Fatigue - physiology Occupational Medicine/Industrial Medicine Original Article Physiology Psychomotor Performance - physiology Serotonin - blood Sports Medicine Temperature Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports Central fatigue Heat Exercise Serotonin Citalopram Physical exercise Human Temperature Central fatigues Physical performance Neurotransmitter Environmental factor Fatigue
ISSN:	1439-6319, 1439-6327, 1439-6327
Online-Zugang:	Volltext
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Zusammenfassung:	The original central fatigue hypothesis suggested that fatigue during prolonged exercise might be due to higher 5-HT activity. Therefore, we examined the effects of acute administration of a selective 5-HT reuptake inhibitor (SSRI) on performance and thermoregulation. Eleven healthy trained male cyclists completed four experimental trials (two in 18°C, two in 30°C) in a double-blind randomised crossover design. Subjects ingested either a placebo (PLA: lactose 2 × 10 mg) or citalopram (CITAL 2 × 10 mg) on the evening before and the morning of the trial. Subjects cycled for 60 min at 55% W max , immediately followed by a time trial (TT) to measure performance. The significance level was set at P < 0.05. Acute SSRI did not significantly change performance on the TT (18°C P = 0.518; 30°C P = 0.112). During recovery at 30°C, core temperature was significantly lower in the CITAL trial ( P < 0.012). At 30°C heart rate was significantly lower after exercise in CITAL ( P = 0.013). CITAL significantly increased cortisol concentrations at rest ( P = 0.016), after the TT ( P = 0.006) and after 15-min recovery ( P = 0.041) at 30°C. 5-HT reuptake inhibition did not cause significant reductions in performance. Core temperature was significantly lower only after the time trial in heat after CITAL administration. The present work failed to prove whether or not 5-HT has an exclusive role in the onset of centrally mediated fatigue during prolonged exercise in both normal and high ambient temperature.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1439-6319 1439-6327 1439-6327
DOI:	10.1007/s00421-009-1109-3