Development and validation of a high-performance liquid chromatography-fluorescence detection method for the accurate quantification of colistin in human plasma

•A HPLC-FLD method was developed for colistin quantification in human plasma.•In-SPE derivatization method was applied for plasma sample preparation.•The developed method was applied to patient plasma samples for TDM. Recently, colistin has become one of the most important drugs for treating infecti...

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Bibliographic Details
Published in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 980; pp. 48 - 54
Main Authors:	Chepyala, Divyabharathi, Tsai, I-Lin, Sun, Hsin-Yun, Lin, Shu-Wen, Kuo, Ching-Hua
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.02.2015
Subjects:	acetonitrile Acetonitriles - chemistry Bacteria Chromatography Chromatography, High Pressure Liquid - methods Colistin Colistin - blood derivatization detection limit Drugs Extraction Fluorescence FMOC-Cl Furans - chemistry Gram-negative bacteria high performance liquid chromatography HPLC-FLD Human Human plasma Humans Liquids methanol Methyl alcohol Monitoring multiple drug resistance Patients Reproducibility of Results statistical analysis tetrahydrofuran Therapeutic drug monitoring trichloroacetic acid Therapeutic drug monitoring FMOC-Cl Human plasma Colistin HPLC-FLD
ISSN:	1570-0232, 1873-376X, 1873-376X
Online Access:	Get full text
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