Pulp Stem Cell-Mediated Functional Pulp Regeneration

The preservation of vital dental pulp with vasculature and nerve components remains one of the most significant challenges in modern dentistry. Due to the immense potential for neurovascularization, mesenchymal stem cell (MSC) transplantation has shown emerging promise in regenerative medicine and d...

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Bibliographic Details
Published in:Journal of dental research Vol. 98; no. 1; p. 27
Main Authors: Sui, B, Chen, C, Kou, X, Li, B, Xuan, K, Shi, S, Jin, Y
Format: Journal Article
Language:English
Published: United States 01.01.2019
Subjects:
Dental Pulp - physiology
Dentin - physiology
Guided Tissue Regeneration, Periodontal - methods
Humans
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Regenerative Medicine
Tissue Engineering - methods
endodontics
neurogenesis
dental pulp
angiogenesis
regenerative medicine
mesenchymal stromal cells
ISSN:1544-0591, 1544-0591
Online Access:Get more information
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Summary:The preservation of vital dental pulp with vasculature and nerve components remains one of the most significant challenges in modern dentistry. Due to the immense potential for neurovascularization, mesenchymal stem cell (MSC) transplantation has shown emerging promise in regenerative medicine and dental translational practice. Actually, pulp mesenchymal stem cells, including postnatal dental pulp stem cells (from permanent teeth) and stem cells from human exfoliated deciduous teeth, possess unique properties based on their origins from neural crest or glial cells. Furthermore, they reside in a neurovascular niche and have the potential for neurogenesis, angiogenesis, and neurovascular inductive activity. According to current pulp regeneration strategies, pulp stem cell-mediated approaches to regeneration have demonstrated convincing evidence that they can rebuild the complex histologic structure of native pulp in situ with highly organized physiologic patterns or even achieve de novo regeneration of complete dental pulp tissues. More importantly, recent clinical studies emphasized in situ neurovascularization outcomes in successful regeneration of vitalized pulp via pulp stem cell transplantation. In this review, we summarize recent breakthroughs in pulp stem cell-mediated pulp regeneration, emphasizing the crucial achievement of neurovascularization. This functional pulp regeneration represents an innovative and promising approach for future regenerative endodontics.
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ISSN:1544-0591
1544-0591
DOI:10.1177/0022034518808754