Retinal nerve fiber layer thickness, brain atrophy, and disability in multiple sclerosis patients

To study the relationship between retinal nerve fiber layer (RNFL) thickness and brain atrophy using magnetic resonance imaging (MRI) with bicaudate ratio (BCR) in patients with multiple sclerosis (MS) with different levels of disease severity. We also assessed whether RNFL thickness correlated with...

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Vydané v:	Journal of neuro-ophthalmology Ročník 34; číslo 1; s. 23
Hlavní autori:	Abalo-Lojo, Jose Manuel, Limeres, Carmen Carollo, Gómez, Manuel Arias, Baleato-González, Sandra, Cadarso-Suárez, Carmen, Capeáns-Tomé, Carmen, Gonzalez, Francisco
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.03.2014
Predmet:	Adult Atrophy - pathology Brain - pathology Disability Evaluation Female Humans Magnetic Resonance Imaging Male Multiple Sclerosis, Relapsing-Remitting - complications Multiple Sclerosis, Relapsing-Remitting - rehabilitation Nerve Fibers - pathology Optic Neuritis - etiology Optic Neuritis - pathology Optic Neuritis - rehabilitation Retinal Ganglion Cells - pathology Retrospective Studies Scanning Laser Polarimetry Severity of Illness Index Tomography, Optical Coherence
ISSN:	1536-5166, 1536-5166
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Abstract	To study the relationship between retinal nerve fiber layer (RNFL) thickness and brain atrophy using magnetic resonance imaging (MRI) with bicaudate ratio (BCR) in patients with multiple sclerosis (MS) with different levels of disease severity. We also assessed whether RNFL thickness correlated with Expanded Disability Status Scale (EDSS) score. The participants consisted of 88 patients with MS and 59 age- and sex-matched healthy control subjects. Eleven patients had clinically isolated syndrome (CIS), 68 patients had relapsing-remitting MS (RR-MS), and 9 patients had secondary progressive MS. Patients and controls were evaluated using optical coherence tomography (OCT, Cirrus) and scanning laser polarimetry with variable corneal compensation (GDx VCC). Patients underwent the same brain MRI scanning protocol. Disability was evaluated according to the EDSS. The BCR was calculated by dividing the minimum intercaudate distance by brain width along the same level. The BCR was higher in patients with MS (0.12 ± 0.03) than in controls (0.08 ± 0.009) (P < 0.001). OCT average RNFL thickness in patients with MS was significantly lower (84.51 ± 14.27 μm) than in control subjects (98.44 ± 6.83 μm). BCR was correlated with OCT average RNFL thickness (r = -0.48, P = 0.002) in patients with MS without optic neuritis. Significant correlations were found between average RNFL thickness and EDSS (r = -0.43, P = 0.003). Additionally, there were correlations between BCR with GDx parameters in patients with MS without optic neuritis. This study shows that RNFL thickness correlates with BCR and with MS subtypes. Additionally, our study indicates that OCT is better suited for MS assessment than GDx. We conclude that the damage of retinal axons appears related to brain damage in patients with MS.
AbstractList	To study the relationship between retinal nerve fiber layer (RNFL) thickness and brain atrophy using magnetic resonance imaging (MRI) with bicaudate ratio (BCR) in patients with multiple sclerosis (MS) with different levels of disease severity. We also assessed whether RNFL thickness correlated with Expanded Disability Status Scale (EDSS) score.OBJECTIVETo study the relationship between retinal nerve fiber layer (RNFL) thickness and brain atrophy using magnetic resonance imaging (MRI) with bicaudate ratio (BCR) in patients with multiple sclerosis (MS) with different levels of disease severity. We also assessed whether RNFL thickness correlated with Expanded Disability Status Scale (EDSS) score.The participants consisted of 88 patients with MS and 59 age- and sex-matched healthy control subjects. Eleven patients had clinically isolated syndrome (CIS), 68 patients had relapsing-remitting MS (RR-MS), and 9 patients had secondary progressive MS. Patients and controls were evaluated using optical coherence tomography (OCT, Cirrus) and scanning laser polarimetry with variable corneal compensation (GDx VCC). Patients underwent the same brain MRI scanning protocol. Disability was evaluated according to the EDSS. The BCR was calculated by dividing the minimum intercaudate distance by brain width along the same level.METHODSThe participants consisted of 88 patients with MS and 59 age- and sex-matched healthy control subjects. Eleven patients had clinically isolated syndrome (CIS), 68 patients had relapsing-remitting MS (RR-MS), and 9 patients had secondary progressive MS. Patients and controls were evaluated using optical coherence tomography (OCT, Cirrus) and scanning laser polarimetry with variable corneal compensation (GDx VCC). Patients underwent the same brain MRI scanning protocol. Disability was evaluated according to the EDSS. The BCR was calculated by dividing the minimum intercaudate distance by brain width along the same level.The BCR was higher in patients with MS (0.12 ± 0.03) than in controls (0.08 ± 0.009) (P < 0.001). OCT average RNFL thickness in patients with MS was significantly lower (84.51 ± 14.27 μm) than in control subjects (98.44 ± 6.83 μm). BCR was correlated with OCT average RNFL thickness (r = -0.48, P = 0.002) in patients with MS without optic neuritis. Significant correlations were found between average RNFL thickness and EDSS (r = -0.43, P = 0.003). Additionally, there were correlations between BCR with GDx parameters in patients with MS without optic neuritis.RESULTSThe BCR was higher in patients with MS (0.12 ± 0.03) than in controls (0.08 ± 0.009) (P < 0.001). OCT average RNFL thickness in patients with MS was significantly lower (84.51 ± 14.27 μm) than in control subjects (98.44 ± 6.83 μm). BCR was correlated with OCT average RNFL thickness (r = -0.48, P = 0.002) in patients with MS without optic neuritis. Significant correlations were found between average RNFL thickness and EDSS (r = -0.43, P = 0.003). Additionally, there were correlations between BCR with GDx parameters in patients with MS without optic neuritis.This study shows that RNFL thickness correlates with BCR and with MS subtypes. Additionally, our study indicates that OCT is better suited for MS assessment than GDx. We conclude that the damage of retinal axons appears related to brain damage in patients with MS.CONCLUSIONSThis study shows that RNFL thickness correlates with BCR and with MS subtypes. Additionally, our study indicates that OCT is better suited for MS assessment than GDx. We conclude that the damage of retinal axons appears related to brain damage in patients with MS. To study the relationship between retinal nerve fiber layer (RNFL) thickness and brain atrophy using magnetic resonance imaging (MRI) with bicaudate ratio (BCR) in patients with multiple sclerosis (MS) with different levels of disease severity. We also assessed whether RNFL thickness correlated with Expanded Disability Status Scale (EDSS) score. The participants consisted of 88 patients with MS and 59 age- and sex-matched healthy control subjects. Eleven patients had clinically isolated syndrome (CIS), 68 patients had relapsing-remitting MS (RR-MS), and 9 patients had secondary progressive MS. Patients and controls were evaluated using optical coherence tomography (OCT, Cirrus) and scanning laser polarimetry with variable corneal compensation (GDx VCC). Patients underwent the same brain MRI scanning protocol. Disability was evaluated according to the EDSS. The BCR was calculated by dividing the minimum intercaudate distance by brain width along the same level. The BCR was higher in patients with MS (0.12 ± 0.03) than in controls (0.08 ± 0.009) (P < 0.001). OCT average RNFL thickness in patients with MS was significantly lower (84.51 ± 14.27 μm) than in control subjects (98.44 ± 6.83 μm). BCR was correlated with OCT average RNFL thickness (r = -0.48, P = 0.002) in patients with MS without optic neuritis. Significant correlations were found between average RNFL thickness and EDSS (r = -0.43, P = 0.003). Additionally, there were correlations between BCR with GDx parameters in patients with MS without optic neuritis. This study shows that RNFL thickness correlates with BCR and with MS subtypes. Additionally, our study indicates that OCT is better suited for MS assessment than GDx. We conclude that the damage of retinal axons appears related to brain damage in patients with MS.
Author	Cadarso-Suárez, Carmen Abalo-Lojo, Jose Manuel Capeáns-Tomé, Carmen Gómez, Manuel Arias Gonzalez, Francisco Limeres, Carmen Carollo Baleato-González, Sandra
Author_xml	– sequence: 1 givenname: Jose Manuel surname: Abalo-Lojo fullname: Abalo-Lojo, Jose Manuel organization: Service of Ophthalmology (JMA-L, CC-T, FG), Complexo Hospitalario Universitario de Santiago de Compostela, La Coruña, Spain; Department of Statistics (CCL, CC-S), School of Medicine, University of Santiago de Compostela, Spain; Service of Neurology (MAG), and Radiology (SBG), Complexo Hospitalario Universitario de Santiago de Compostela, Spain; Department of Surgery and CIMUS (FG), University of Santiago de Compostela, Spain; and Insituto de Investigacion Sanitaria (FG), Santiago de Compostela, Spain – sequence: 2 givenname: Carmen Carollo surname: Limeres fullname: Limeres, Carmen Carollo – sequence: 3 givenname: Manuel Arias surname: Gómez fullname: Gómez, Manuel Arias – sequence: 4 givenname: Sandra surname: Baleato-González fullname: Baleato-González, Sandra – sequence: 5 givenname: Carmen surname: Cadarso-Suárez fullname: Cadarso-Suárez, Carmen – sequence: 6 givenname: Carmen surname: Capeáns-Tomé fullname: Capeáns-Tomé, Carmen – sequence: 7 givenname: Francisco surname: Gonzalez fullname: Gonzalez, Francisco
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SubjectTerms	Adult Atrophy - pathology Brain - pathology Disability Evaluation Female Humans Magnetic Resonance Imaging Male Multiple Sclerosis, Relapsing-Remitting - complications Multiple Sclerosis, Relapsing-Remitting - rehabilitation Nerve Fibers - pathology Optic Neuritis - etiology Optic Neuritis - pathology Optic Neuritis - rehabilitation Retinal Ganglion Cells - pathology Retrospective Studies Scanning Laser Polarimetry Severity of Illness Index Tomography, Optical Coherence
Title	Retinal nerve fiber layer thickness, brain atrophy, and disability in multiple sclerosis patients
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