The GABA system, a new target for medications against cognitive impairment—Associated with neuroactive steroids

The prevalence of cognitive dysfunction, dementia, and neurodegenerative disorders such as Alzheimer's disease (AD) is increasing in parallel with an aging population. Distinct types of chronic stress are thought to be instrumental in the development of cognitive impairment in central nervous s...

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Veröffentlicht in:	Journal of internal medicine Jg. 294; H. 3; S. 281 - 294
Hauptverfasser:	Bäckström, Torbjörn, Turkmen, Sahruh, Das, Roshni, Doverskog, Magnus, Blackburn, Thomas P.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Blackwell Publishing Ltd 01.09.2023
Schlagworte:	Acetic acid Aged allopregnanolone Alzheimer Disease - drug therapy Alzheimer's disease Animal cognition Animals Central nervous system Cognition Cognitive ability Cognitive Dysfunction - drug therapy dementia Dementia disorders GABA-A receptor gamma-Aminobutyric Acid - pharmacology Hepatic encephalopathy Humans Impairment Medroxyprogesterone acetate Memory Neurodegenerative diseases Neurosteroids Neurosteroids - therapeutic use Pregnanolone Pregnanolone - pharmacology Receptors Receptors, GABA-A Steroid hormones Steroids Transgenic animals γ-Aminobutyric acid dementia allopregnanolone memory GABA-A receptor neurosteroids
ISSN:	0954-6820, 1365-2796, 1365-2796
Online-Zugang:	Volltext
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