Advances and highlights in asthma in 2021

Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with nove...

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Published in:Allergy (Copenhagen) Vol. 76; no. 11; pp. 3390 - 3407
Main Authors: Agache, Ioana, Eguiluz‐Gracia, Ibon, Cojanu, Catalina, Laculiceanu, Alexandru, Giacco, Stefano, Zemelka‐Wiacek, Magdalena, Kosowska, Anna, Akdis, Cezmi A., Jutel, Marek
Format: Journal Article
Language:English
Published: Zurich Blackwell Publishing Ltd 01.11.2021
Subjects:
Artificial intelligence
Asthma
biomarkers
Clinical trials
endotypes
Epigenetics
exacerbations
guidelines
Immune system
Innate immunity
Pandemics
ISSN:0105-4538, 1398-9995, 1398-9995
Online Access:Get full text
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Abstract Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality real‐world evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.
AbstractList Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality real-world evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality real-world evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.
Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality real‐world evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.
Author Laculiceanu, Alexandru
Akdis, Cezmi A.
Agache, Ioana
Cojanu, Catalina
Eguiluz‐Gracia, Ibon
Kosowska, Anna
Jutel, Marek
Giacco, Stefano
Zemelka‐Wiacek, Magdalena
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  givenname: Catalina
  surname: Cojanu
  fullname: Cojanu, Catalina
  organization: Transylvania University
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  givenname: Alexandru
  orcidid: 0000-0003-4772-0569
  surname: Laculiceanu
  fullname: Laculiceanu, Alexandru
  organization: Transylvania University
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  givenname: Stefano
  surname: Giacco
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  fullname: Zemelka‐Wiacek, Magdalena
  organization: Wroclaw Medical University
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  surname: Kosowska
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  organization: All‐MED Medical Research Institute
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  givenname: Cezmi A.
  orcidid: 0000-0001-8020-019X
  surname: Akdis
  fullname: Akdis, Cezmi A.
  organization: University of Zurich
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  givenname: Marek
  surname: Jutel
  fullname: Jutel, Marek
  organization: All‐MED Medical Research Institute
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Notes [Correction added on 06_October_2021, after first online publication. The affiliations of Marek Jutel have been corrected.].
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PublicationCentury 2000
PublicationDate November 2021
PublicationDateYYYYMMDD 2021-11-01
PublicationDate_xml – month: 11
  year: 2021
  text: November 2021
PublicationDecade 2020
PublicationPlace Zurich
PublicationPlace_xml – name: Zurich
PublicationTitle Allergy (Copenhagen)
PublicationYear 2021
Publisher Blackwell Publishing Ltd
Publisher_xml – name: Blackwell Publishing Ltd
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Snippet Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on...
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SubjectTerms Artificial intelligence
Asthma
biomarkers
Clinical trials
endotypes
Epigenetics
exacerbations
guidelines
Immune system
Innate immunity
Pandemics
Title Advances and highlights in asthma in 2021
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