Exosomal lncRNAs and cancer: connecting the missing links

Abstract Motivation Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the targeted treatment of cancer. The content of EVs is closely related to the type and status of the EV-secreting cell. Cir...

Full description

Saved in:
Bibliographic Details
Published in:Bioinformatics Vol. 35; no. 2; pp. 352 - 360
Main Authors: Naderi-Meshkin, Hojjat, Lai, Xin, Amirkhah, Raheleh, Vera, Julio, Rasko, John E J, Schmitz, Ulf
Format: Journal Article
Language:English
Published: England Oxford University Press 15.01.2019
ISSN:1367-4803, 1367-4811, 1460-2059, 1367-4811
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Abstract Motivation Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the targeted treatment of cancer. The content of EVs is closely related to the type and status of the EV-secreting cell. Circulating exosomes are a source of stable RNAs including mRNAs, microRNAs and long non-coding RNAs (lncRNAs). Results This review outlines the links between EVs, lncRNAs and cancer. We highlight communication networks involving the tumor microenvironment, the immune system and metastasis. We show examples supporting the value of exosomal lncRNAs as cancer biomarkers and therapeutic targets. We demonstrate how a system biology approach can be used to model cell-cell communication via exosomal lncRNAs and to simulate effects of therapeutic interventions. In addition, we introduce algorithms and bioinformatics resources for the discovery of tumor-specific lncRNAs and tools that are applied to determine exosome content and lncRNA function. Finally, this review provides a comprehensive collection and guide to databases for exosomal lncRNAs. Supplementary information Supplementary data are available at Bioinformatics online.
AbstractList Abstract Motivation Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the targeted treatment of cancer. The content of EVs is closely related to the type and status of the EV-secreting cell. Circulating exosomes are a source of stable RNAs including mRNAs, microRNAs and long non-coding RNAs (lncRNAs). Results This review outlines the links between EVs, lncRNAs and cancer. We highlight communication networks involving the tumor microenvironment, the immune system and metastasis. We show examples supporting the value of exosomal lncRNAs as cancer biomarkers and therapeutic targets. We demonstrate how a system biology approach can be used to model cell-cell communication via exosomal lncRNAs and to simulate effects of therapeutic interventions. In addition, we introduce algorithms and bioinformatics resources for the discovery of tumor-specific lncRNAs and tools that are applied to determine exosome content and lncRNA function. Finally, this review provides a comprehensive collection and guide to databases for exosomal lncRNAs. Supplementary information Supplementary data are available at Bioinformatics online.
Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the targeted treatment of cancer. The content of EVs is closely related to the type and status of the EV-secreting cell. Circulating exosomes are a source of stable RNAs including mRNAs, microRNAs and long non-coding RNAs (lncRNAs). This review outlines the links between EVs, lncRNAs and cancer. We highlight communication networks involving the tumor microenvironment, the immune system and metastasis. We show examples supporting the value of exosomal lncRNAs as cancer biomarkers and therapeutic targets. We demonstrate how a system biology approach can be used to model cell-cell communication via exosomal lncRNAs and to simulate effects of therapeutic interventions. In addition, we introduce algorithms and bioinformatics resources for the discovery of tumor-specific lncRNAs and tools that are applied to determine exosome content and lncRNA function. Finally, this review provides a comprehensive collection and guide to databases for exosomal lncRNAs. Supplementary data are available at Bioinformatics online.
Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the targeted treatment of cancer. The content of EVs is closely related to the type and status of the EV-secreting cell. Circulating exosomes are a source of stable RNAs including mRNAs, microRNAs and long non-coding RNAs (lncRNAs).MotivationExtracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the targeted treatment of cancer. The content of EVs is closely related to the type and status of the EV-secreting cell. Circulating exosomes are a source of stable RNAs including mRNAs, microRNAs and long non-coding RNAs (lncRNAs).This review outlines the links between EVs, lncRNAs and cancer. We highlight communication networks involving the tumor microenvironment, the immune system and metastasis. We show examples supporting the value of exosomal lncRNAs as cancer biomarkers and therapeutic targets. We demonstrate how a system biology approach can be used to model cell-cell communication via exosomal lncRNAs and to simulate effects of therapeutic interventions. In addition, we introduce algorithms and bioinformatics resources for the discovery of tumor-specific lncRNAs and tools that are applied to determine exosome content and lncRNA function. Finally, this review provides a comprehensive collection and guide to databases for exosomal lncRNAs.ResultsThis review outlines the links between EVs, lncRNAs and cancer. We highlight communication networks involving the tumor microenvironment, the immune system and metastasis. We show examples supporting the value of exosomal lncRNAs as cancer biomarkers and therapeutic targets. We demonstrate how a system biology approach can be used to model cell-cell communication via exosomal lncRNAs and to simulate effects of therapeutic interventions. In addition, we introduce algorithms and bioinformatics resources for the discovery of tumor-specific lncRNAs and tools that are applied to determine exosome content and lncRNA function. Finally, this review provides a comprehensive collection and guide to databases for exosomal lncRNAs.Supplementary data are available at Bioinformatics online.Supplementary informationSupplementary data are available at Bioinformatics online.
Author Rasko, John E J
Naderi-Meshkin, Hojjat
Vera, Julio
Lai, Xin
Amirkhah, Raheleh
Schmitz, Ulf
Author_xml – sequence: 1
  givenname: Hojjat
  surname: Naderi-Meshkin
  fullname: Naderi-Meshkin, Hojjat
  organization: Stem Cells & Regenerative Medicine Research Group, Academic Center for Education, Culture Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran
– sequence: 2
  givenname: Xin
  surname: Lai
  fullname: Lai, Xin
  organization: Laboratory of Systems Tumour Immunology, Department of Dermatology, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany
– sequence: 3
  givenname: Raheleh
  surname: Amirkhah
  fullname: Amirkhah, Raheleh
  organization: Nastaran Center for Cancer Prevention, Mashhad, Iran
– sequence: 4
  givenname: Julio
  surname: Vera
  fullname: Vera, Julio
  organization: Laboratory of Systems Tumour Immunology, Department of Dermatology, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany
– sequence: 5
  givenname: John E J
  surname: Rasko
  fullname: Rasko, John E J
  organization: Gene and Stem Cell Therapy Program, Centenary Institute, University of Sydney, Camperdown, Australia
– sequence: 6
  givenname: Ulf
  surname: Schmitz
  fullname: Schmitz, Ulf
  email: u.schmitz@centenary.org.au
  organization: Gene and Stem Cell Therapy Program, Centenary Institute, University of Sydney, Camperdown, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30649349$$D View this record in MEDLINE/PubMed
BookMark eNqNkElPwzAQhS1URBf4CaAcuYTa9ZIaTqgqi1SBhHqPHHsChsQudiLRf0-qFCS4wGmeRt-b5Y3RwHkHCJ0SfEGwpNPCeutKH2rVWB2nRbPls-wAjQgTOJ1hLgedpiJL2RzTIRrH-IoxJ4yxIzSkWDBJmRwhufzw0deqSiqnnx6uY6KcSbRyGsJlor1zoBvrnpPmBZLaxrjTlXVv8RgdlqqKcLKvE7S-Wa4Xd-nq8fZ-cb1KNaO4SYEapSgwrRmZMyMEN4bMKaW8LHipAbCZa84ZLgQxnIGQqmtgYAWWMmN0gs77sZvg31uITd5doaGqlAPfxnxGMkklyUTWoWd7tC1qMPkm2FqFbf71bQfwHtDBxxig_EYIznep5j9TzftUO9_VL5-2TUd41wRlqz_duHf7dvPPhZ-_W5Z-
CitedBy_id crossref_primary_10_1016_j_heliyon_2024_e35051
crossref_primary_10_1089_dna_2020_5783
crossref_primary_10_3390_cancers13235944
crossref_primary_10_1093_nar_gkaa1076
crossref_primary_10_3390_biom11040522
crossref_primary_10_1111_jcmm_15713
crossref_primary_10_1016_j_gene_2019_06_004
crossref_primary_10_1002_jcb_30425
crossref_primary_10_1002_cbin_11660
crossref_primary_10_3390_genes12030455
crossref_primary_10_1038_s41598_022_26894_5
crossref_primary_10_1007_s12032_025_02791_5
crossref_primary_10_1097_MD_0000000000018031
crossref_primary_10_1186_s12929_020_00654_x
crossref_primary_10_1002_adma_202306583
crossref_primary_10_1038_s41598_024_63633_4
crossref_primary_10_1111_jcmm_16219
crossref_primary_10_1002_jcp_30697
crossref_primary_10_1016_j_cca_2021_01_003
crossref_primary_10_1038_s41598_019_49431_3
crossref_primary_10_3389_fcell_2020_00619
crossref_primary_10_3389_fonc_2025_1615433
crossref_primary_10_1016_j_prp_2024_155123
crossref_primary_10_1016_j_heliyon_2024_e28148
crossref_primary_10_1002_adhm_202000255
crossref_primary_10_1016_j_semcancer_2019_06_008
crossref_primary_10_1111_cpr_13375
crossref_primary_10_1016_j_ygeno_2021_11_026
crossref_primary_10_3389_fonc_2021_718876
crossref_primary_10_3389_fonc_2022_1008856
crossref_primary_10_3389_fsurg_2022_933781
crossref_primary_10_1007_s10238_023_01181_3
crossref_primary_10_3389_fphar_2024_1442227
crossref_primary_10_1038_s41392_020_0129_7
crossref_primary_10_1016_j_prp_2024_155570
crossref_primary_10_1016_j_tube_2021_102065
crossref_primary_10_3390_cells8080929
crossref_primary_10_3390_ijms22063211
crossref_primary_10_1038_s41420_021_00631_9
crossref_primary_10_1186_s13046_021_02114_2
crossref_primary_10_1016_j_biopha_2020_110329
crossref_primary_10_1093_bib_bbab343
crossref_primary_10_1186_s13045_021_01088_0
crossref_primary_10_1096_fj_201901610
crossref_primary_10_1038_s41419_021_04281_8
crossref_primary_10_1038_s41388_019_1040_y
crossref_primary_10_1016_j_omtn_2021_05_023
crossref_primary_10_3390_cancers11081170
crossref_primary_10_1631_jzus_B1900051
crossref_primary_10_3389_fgene_2022_918705
crossref_primary_10_3389_fimmu_2022_731516
Cites_doi 10.1038/gt.2017.8
10.1186/s12935-018-0506-2
10.1126/scisignal.2000568
10.1126/science.1192002
10.1186/s12943-017-0714-8
10.1080/15384047.2017.1394544
10.3402/jev.v5.30829
10.1016/j.coi.2014.01.004
10.1182/blood-2006-01-0092
10.1073/pnas.1416745111
10.1093/bioinformatics/btt426
10.1016/j.ejca.2013.04.026
10.3892/or.2017.5742
10.1158/1055-9965.EPI-16-0006
10.1038/cdd.2016.95
10.1002/hep.25873
10.1158/0008-5472.CAN-12-2184
10.1016/j.fob.2014.04.007
10.1007/s00432-017-2361-2
10.1038/nbt.1807
10.1186/s13287-015-0150-x
10.3402/jev.v5.31053
10.1093/bib/bbv061
10.1007/s13277-014-2807-y
10.1038/srep24967
10.1016/j.bbrc.2017.05.136
10.1371/journal.pone.0147236
10.1093/nar/gkx1004
10.1002/cbin.10301
10.1038/nrurol.2011.10
10.1371/journal.pone.0087797
10.1039/C4MB00439F
10.1186/s12935-017-0430-x
10.1016/j.semcdb.2015.02.005
10.1038/nature15756
10.1186/s13045-017-0426-y
10.1038/srep24922
10.1093/nar/gkv1094
10.1101/gad.270959.115
10.1007/s11538-017-0254-9
10.1016/j.ccell.2016.03.004
10.3892/br.2017.848
10.1038/oncsis.2015.48
10.1016/j.bbapap.2013.05.007
10.1016/j.ncrna.2016.06.001
10.1007/s11538-018-0412-8
10.1093/nar/gkx891
10.1016/j.biosystems.2018.01.006
10.1177/1947601913499020
10.1038/srep41544
10.1371/journal.pbio.1001450
10.1093/annonc/mdx542
10.1080/20013078.2017.1321455
10.1039/C6CP07767F
10.1093/database/bap008
10.1016/j.bbamem.2014.07.026
10.1038/s41598-017-00966-3
10.1039/C4MB00478G
10.1038/nmeth.3433
10.1098/rsif.2017.0105
10.18632/oncotarget.2118
10.1186/s13326-016-0061-5
10.1016/j.cell.2014.09.051
10.1088/1367-2630/17/5/055021
10.1186/s13046-017-0587-0
10.1016/j.ccr.2007.03.012
10.1016/j.jdermsci.2015.10.019
10.1101/gr.135350.111
10.1016/j.bbrc.2014.12.015
10.1158/1541-7786.MCR-13-0636
10.18632/oncotarget.12880
10.1016/j.biocel.2013.05.030
10.15252/embr.201540437
10.1016/j.pharmthera.2017.02.020
10.1016/j.tcb.2016.11.003
10.1038/nature22341
10.1080/20013078.2017.1286095
10.1016/j.cell.2014.10.013
10.1126/science.aah7111
10.1093/nar/gkw945
10.1002/cncr.31078
10.2147/OTT.S155134
10.1038/nm.2753
10.1002/jcla.21990
10.1093/nar/gkx854
10.18632/oncotarget.22371
10.1016/j.bbrc.2017.06.055
10.1038/ncb3169
10.18632/oncotarget.18831
10.1016/j.canlet.2016.12.005
10.1016/j.lfs.2018.02.006
10.1089/scd.2013.0594
10.1016/j.yexmp.2016.05.013
10.1002/pmic.201600432
10.1080/2162402X.2017.1362527
10.1371/journal.pcbi.1002742
10.1016/j.jmb.2015.09.019
ContentType Journal Article
Copyright The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2018
Copyright_xml – notice: The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2018
DBID AAYXX
CITATION
NPM
7X8
DOI 10.1093/bioinformatics/bty527
DatabaseName CrossRef
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList
PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1460-2059
1367-4811
EndPage 360
ExternalDocumentID 30649349
10_1093_bioinformatics_bty527
10.1093/bioinformatics/bty527
Genre Journal Article
GrantInformation_xml – fundername: Cancer Institute NSW
  sequence: 0
  grantid: ECF171267
  funderid: 10.13039/501100001171
– fundername: German Federal Ministry of Education and Research
  sequence: 0
  grantid: 031L0073A
– fundername: ELAN-fund of Universitätsklinikum Erlangen
  sequence: 0
  grantid: 16-08-16-1-Lai
– fundername: eBio: SysMet
  sequence: 0
  grantid: 0316171
GroupedDBID -~X
.2P
5GY
AAMVS
ABPTD
ACGFS
ADZXQ
ALMA_UNASSIGNED_HOLDINGS
BCRHZ
F5P
HW0
Q5Y
RD5
ROX
TLC
TN5
TOX
WH7
---
-E4
.DC
.I3
0R~
23N
2WC
4.4
48X
53G
5WA
70D
AAIJN
AAIMJ
AAJKP
AAKPC
AAMDB
AAOGV
AAPQZ
AAPXW
AAUQX
AAVAP
AAVLN
AAYXX
ABEJV
ABEUO
ABGNP
ABIXL
ABNKS
ABPQP
ABQLI
ABWST
ABXVV
ABZBJ
ACIWK
ACPRK
ACUFI
ACUXJ
ACYTK
ADBBV
ADEYI
ADEZT
ADFTL
ADGKP
ADGZP
ADHKW
ADHZD
ADMLS
ADOCK
ADPDF
ADRDM
ADRTK
ADVEK
ADYVW
ADZTZ
AECKG
AEGPL
AEJOX
AEKKA
AEKSI
AELWJ
AEMDU
AENEX
AENZO
AEPUE
AETBJ
AEWNT
AFFZL
AFGWE
AFIYH
AFOFC
AFRAH
AGINJ
AGKEF
AGQXC
AGSYK
AHMBA
AHXPO
AIJHB
AJEEA
AJEUX
AKHUL
AKWXX
ALTZX
ALUQC
AMNDL
APIBT
APWMN
ARIXL
ASPBG
AVWKF
AXUDD
AYOIW
AZVOD
BAWUL
BAYMD
BHONS
BQDIO
BQUQU
BSWAC
BTQHN
C45
CDBKE
CITATION
CS3
CZ4
DAKXR
DIK
DILTD
DU5
D~K
EBD
EBS
EE~
EJD
EMOBN
F9B
FEDTE
FHSFR
FLIZI
FLUFQ
FOEOM
FQBLK
GAUVT
GJXCC
GROUPED_DOAJ
GX1
H13
H5~
HAR
HZ~
IOX
J21
JXSIZ
KAQDR
KOP
KQ8
KSI
KSN
M-Z
MK~
ML0
N9A
NGC
NLBLG
NMDNZ
NOMLY
NU-
O9-
OAWHX
ODMLO
OJQWA
OK1
OVD
OVEED
P2P
PAFKI
PEELM
PQQKQ
Q1.
R44
RNS
ROL
RPM
RUSNO
RW1
RXO
SV3
TEORI
TJP
TR2
W8F
WOQ
X7H
YAYTL
YKOAZ
YXANX
ZKX
~91
~KM
ADRIX
AFXEN
M49
NPM
7X8
ID FETCH-LOGICAL-c430t-e3daa3e4cc4184d665dd183335fb5fcee0d8c5540b61d54e69ad8c0e4b099743
IEDL.DBID TOX
ISICitedReferencesCount 58
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000459314900026&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1367-4803
1367-4811
IngestDate Thu Jul 10 20:01:47 EDT 2025
Wed Feb 19 02:34:32 EST 2025
Sat Nov 29 05:34:13 EST 2025
Tue Nov 18 21:10:23 EST 2025
Fri Dec 06 10:16:18 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c430t-e3daa3e4cc4184d665dd183335fb5fcee0d8c5540b61d54e69ad8c0e4b099743
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
OpenAccessLink https://academic.oup.com/bioinformatics/article-pdf/35/2/352/27497005/bty527.pdf
PMID 30649349
PQID 2179391767
PQPubID 23479
PageCount 9
ParticipantIDs proquest_miscellaneous_2179391767
pubmed_primary_30649349
crossref_primary_10_1093_bioinformatics_bty527
crossref_citationtrail_10_1093_bioinformatics_bty527
oup_primary_10_1093_bioinformatics_bty527
PublicationCentury 2000
PublicationDate 20190115
2019-01-15
2019-Jan-15
PublicationDateYYYYMMDD 2019-01-15
PublicationDate_xml – month: 01
  year: 2019
  text: 20190115
  day: 15
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Bioinformatics
PublicationTitleAlternate Bioinformatics
PublicationYear 2019
Publisher Oxford University Press
Publisher_xml – sequence: 0
  name: Oxford University Press
References Mittal (2023013107225696100_bty527-B63) 2014; 27
Huan (2023013107225696100_bty527-B22) 2013; 73
Smyth (2023013107225696100_bty527-B81) 2014; 1838
Xia (2023013107225696100_bty527-B91) 2017; 489
Boelens (2023013107225696100_bty527-B9) 2014; 159
Mateescu (2023013107225696100_bty527-B61) 2017; 6
Toda (2023013107225696100_bty527-B85) 2015; 456
Friedman (2023013107225696100_bty527-B16) 2017; 80
Li (2023013107225696100_bty527-B50) 2017; 24
Harrow (2023013107225696100_bty527-B19) 2012; 22
Ahadi (2023013107225696100_bty527-B2) 2016; 6
Ning (2023013107225696100_bty527-B65) 2016; 44
Khan (2023013107225696100_bty527-B32) 2014; 1844
Arun (2023013107225696100_bty527-B5) 2016; 30
Maas (2023013107225696100_bty527-B58) 2017; 27
Lu (2023013107225696100_bty527-B55) 2014; 111
Zhang (2023013107225696100_bty527-B100) 2018; 11
Keerthikumar (2023013107225696100_bty527-B30) 2016; 428
Cheung (2023013107225696100_bty527-B12) 2016; 7
Iwai (2023013107225696100_bty527-B24) 2016; 5
Kamerkar (2023013107225696100_bty527-B29) 2017; 546
Costa-Silva (2023013107225696100_bty527-B13) 2015; 17
Hewson (2023013107225696100_bty527-B20) 2016; 1
Li (2023013107225696100_bty527-B49) 2018; 46
Dong (2023013107225696100_bty527-B14) 2016; 25
Takahashi (2023013107225696100_bty527-B82) 2014; 127
Kim (2023013107225696100_bty527-B33) 2015; 40
Lang (2023013107225696100_bty527-B41) 2017; 38
Quesenberry (2023013107225696100_bty527-B72) 2015; 6
Gao (2023013107225696100_bty527-B17) 2018; 18
Lang (2023013107225696100_bty527-B40) 2017; 21
Yang (2023013107225696100_bty527-B95) 2014; 9
Russo (2023013107225696100_bty527-B75) 2018; 46
Ye (2023013107225696100_bty527-B96) 2014; 5
Zhang (2023013107225696100_bty527-B99) 2016; 30
Alvarez-Erviti (2023013107225696100_bty527-B3) 2011; 29
Li (2023013107225696100_bty527-B44) 2017; 19
Takahashi (2023013107225696100_bty527-B84) 2014; 12
Nishiyama (2023013107225696100_bty527-B66) 2018; 165
Yu (2023013107225696100_bty527-B97) 2017; 8
Jiang (2023013107225696100_bty527-B25) 2017; 24
Hoshino (2023013107225696100_bty527-B21) 2015; 527
Hughes (2023013107225696100_bty527-B23) 2006; 108
Özeş (2023013107225696100_bty527-B67) 2017; 7
Li (2023013107225696100_bty527-B45) 2018; 197
Lobb (2023013107225696100_bty527-B54) 2017; 17
Wu (2023013107225696100_bty527-B89) 2017; 17
Lagana (2023013107225696100_bty527-B39) 2009; 2009
Liu (2023013107225696100_bty527-B53) 2015; 11
Koldemir (2023013107225696100_bty527-B37) 2017; 6
Xu (2023013107225696100_bty527-B93) 2016; 20
Kim (2023013107225696100_bty527-B34) 2012; 8
Castillo (2023013107225696100_bty527-B10) 2018; 29
Sharma (2023013107225696100_bty527-B78) 2015; 16
Lee (2023013107225696100_bty527-B43) 2011; 8
Jolly (2023013107225696100_bty527-B27) 2015; 17
Zhao (2023013107225696100_bty527-B102) 2015; 11
Chen (2023013107225696100_bty527-B11) 2013; 29
Tsai (2023013107225696100_bty527-B86) 2010; 329
Xue (2023013107225696100_bty527-B94) 2017; 16
Kooijmans (2023013107225696100_bty527-B38) 2016; 5
Lutgendorf (2023013107225696100_bty527-B56) 2018; 124
Ma (2023013107225696100_bty527-B57) 2017; 10
Santos (2023013107225696100_bty527-B76) 2016; 6
Schmitz (2023013107225696100_bty527-B77) 2016; 17
Li (2023013107225696100_bty527-B47) 2015; 36
Liu (2023013107225696100_bty527-B51) 2017; 388
Pathan (2023013107225696100_bty527-B69) 2017; 6
Kogure (2023013107225696100_bty527-B36) 2013; 4
Shechner (2023013107225696100_bty527-B79) 2015; 12
Ning (2023013107225696100_bty527-B64) 2017; 45
Khan (2023013107225696100_bty527-B31) 2018; 19
Li (2023013107225696100_bty527-B48) 2017; 7
Miao (2023013107225696100_bty527-B62) 2018; 46
Kino (2023013107225696100_bty527-B35) 2010; 3
Gezer (2023013107225696100_bty527-B18) 2014; 38
Abdouh (2023013107225696100_bty527-B1) 2017; 36
Macfarlane (2023013107225696100_bty527-B60) 2018; 80
Shen (2023013107225696100_bty527-B80) 2017; 6
Bala (2023013107225696100_bty527-B6) 2012; 56
Berrondo (2023013107225696100_bty527-B8) 2016; 11
Ren (2023013107225696100_bty527-B74) 2013; 49
Duan (2023013107225696100_bty527-B15) 2016; 7
Wu (2023013107225696100_bty527-B90) 2016; 5
Barile (2023013107225696100_bty527-B7) 2017; 174
Johnsen (2023013107225696100_bty527-B26) 2014; 1846
Takahashi (2023013107225696100_bty527-B83) 2014; 4
Aqil (2023013107225696100_bty527-B4) 2016; 101
Vallabhaneni (2023013107225696100_bty527-B87) 2017; 8
Xing (2023013107225696100_bty527-B92) 2014; 159
Quesenberry (2023013107225696100_bty527-B73) 2014; 23
Pan (2023013107225696100_bty527-B68) 2017; 143
Lanzós (2023013107225696100_bty527-B42) 2017; 7
MacDiarmid (2023013107225696100_bty527-B59) 2007; 11
Kalra (2023013107225696100_bty527-B28) 2012; 10
Peinado (2023013107225696100_bty527-B70) 2012; 18
Zeng (2023013107225696100_bty527-B98) 2016; 81
Liu (2023013107225696100_bty527-B52) 2017; 355
Qu (2023013107225696100_bty527-B71) 2016; 29
Zhang (2023013107225696100_bty527-B101) 2017; 490
Li (2023013107225696100_bty527-B46) 2013; 45
Wenbo (2023013107225696100_bty527-B88) 2017; 14
References_xml – volume: 24
  start-page: 157
  year: 2017
  ident: 2023013107225696100_bty527-B25
  article-title: Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy
  publication-title: Gene Ther
  doi: 10.1038/gt.2017.8
– volume: 18
  start-page: 11
  year: 2018
  ident: 2023013107225696100_bty527-B17
  article-title: Exosomal lncRNA 91H is associated with poor development in colorectal cancer by modifying HNRNPK expression
  publication-title: Cancer Cell Int
  doi: 10.1186/s12935-018-0506-2
– volume: 3
  start-page: ra8
  year: 2010
  ident: 2023013107225696100_bty527-B35
  article-title: Noncoding RNA Gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor
  publication-title: Sci. Signal
  doi: 10.1126/scisignal.2000568
– volume: 329
  start-page: 689
  year: 2010
  ident: 2023013107225696100_bty527-B86
  article-title: Long noncoding RNA as modular scaffold of histone modification complexes
  publication-title: Science
  doi: 10.1126/science.1192002
– volume: 16
  start-page: 143
  year: 2017
  ident: 2023013107225696100_bty527-B94
  article-title: Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1
  publication-title: Mol. Cancer
  doi: 10.1186/s12943-017-0714-8
– volume: 19
  start-page: 25
  year: 2018
  ident: 2023013107225696100_bty527-B31
  article-title: Inhibition of exosome release by ketotifen enhances sensitivity of cancer cells to doxorubicin
  publication-title: Cancer Biol. Ther
  doi: 10.1080/15384047.2017.1394544
– volume: 5
  start-page: 30829
  year: 2016
  ident: 2023013107225696100_bty527-B24
  article-title: Isolation of human salivary extracellular vesicles by iodixanol density gradient ultracentrifugation and their characterizations
  publication-title: J. Extracell. Vesicles
  doi: 10.3402/jev.v5.30829
– volume: 27
  start-page: 16
  year: 2014
  ident: 2023013107225696100_bty527-B63
  article-title: New insights into cancer immunoediting and its three component phases–elimination, equilibrium and escape
  publication-title: Curr. Opin. Immunol
  doi: 10.1016/j.coi.2014.01.004
– volume: 108
  start-page: 28
  year: 2006
  ident: 2023013107225696100_bty527-B23
  article-title: Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
  publication-title: Blood
  doi: 10.1182/blood-2006-01-0092
– volume: 111
  start-page: E4165
  year: 2014
  ident: 2023013107225696100_bty527-B55
  article-title: Modeling putative therapeutic implications of exosome exchange between tumor and immune cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1416745111
– volume: 29
  start-page: 2617
  year: 2013
  ident: 2023013107225696100_bty527-B11
  article-title: Novel human lncRNA–disease association inference based on lncRNA expression profiles
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt426
– volume: 49
  start-page: 2949
  year: 2013
  ident: 2023013107225696100_bty527-B74
  article-title: Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2013.04.026
– volume: 38
  start-page: 785
  year: 2017
  ident: 2023013107225696100_bty527-B41
  article-title: Glioma cells enhance angiogenesis and inhibit endothelial cell apoptosis through the release of exosomes that contain long non-coding RNA CCAT2
  publication-title: Oncol. Rep
  doi: 10.3892/or.2017.5742
– volume: 25
  start-page: 1158
  year: 2016
  ident: 2023013107225696100_bty527-B14
  article-title: Circulating long RNAs in serum extracellular vesicles: their characterization and potential application as biomarkers for diagnosis of colorectal cancer
  publication-title: Cancer Epidemiol. Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-16-0006
– volume: 24
  start-page: 59
  year: 2017
  ident: 2023013107225696100_bty527-B50
  article-title: The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2016.95
– volume: 56
  start-page: 1946
  year: 2012
  ident: 2023013107225696100_bty527-B6
  article-title: Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases
  publication-title: Hepatology
  doi: 10.1002/hep.25873
– volume: 73
  start-page: 918
  year: 2013
  ident: 2023013107225696100_bty527-B22
  article-title: RNA trafficking by acute myelogenous leukemia exosomes
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-12-2184
– volume: 4
  start-page: 458
  year: 2014
  ident: 2023013107225696100_bty527-B83
  article-title: Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer
  publication-title: FEBS Open Biol
  doi: 10.1016/j.fob.2014.04.007
– volume: 143
  start-page: 991
  year: 2017
  ident: 2023013107225696100_bty527-B68
  article-title: Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression
  publication-title: J. Cancer Res. Clin. Oncol
  doi: 10.1007/s00432-017-2361-2
– volume: 29
  start-page: 341
  year: 2011
  ident: 2023013107225696100_bty527-B3
  article-title: Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
  publication-title: Nat. Biotechnol
  doi: 10.1038/nbt.1807
– volume: 6
  year: 2015
  ident: 2023013107225696100_bty527-B72
  article-title: Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming
  publication-title: Stem Cell Res. Ther
  doi: 10.1186/s13287-015-0150-x
– volume: 5
  start-page: 31053
  year: 2016
  ident: 2023013107225696100_bty527-B38
  article-title: Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting
  publication-title: J. Extracell. Vesicles
  doi: 10.3402/jev.v5.31053
– volume: 17
  start-page: 380
  year: 2016
  ident: 2023013107225696100_bty527-B77
  article-title: The RNA world in the 21st century—a systems approach to finding non-coding keys to clinical questions
  publication-title: Brief. Bioinformatics
  doi: 10.1093/bib/bbv061
– volume: 36
  start-page: 2007
  year: 2015
  ident: 2023013107225696100_bty527-B47
  article-title: Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer
  publication-title: Tumour Biol
  doi: 10.1007/s13277-014-2807-y
– volume: 6
  year: 2016
  ident: 2023013107225696100_bty527-B76
  article-title: Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis
  publication-title: Sci. Rep
  doi: 10.1038/srep24967
– volume: 489
  start-page: 386
  year: 2017
  ident: 2023013107225696100_bty527-B91
  article-title: Targeting long non-coding RNA ASBEL with oligonucleotide antagonist for breast cancer therapy
  publication-title: Biochem. Biophys. Res. Commun
  doi: 10.1016/j.bbrc.2017.05.136
– volume: 11
  start-page: e0147236
  year: 2016
  ident: 2023013107225696100_bty527-B8
  article-title: Expression of the long non-coding RNA HOTAIR correlates with disease progression in bladder cancer and is contained in bladder cancer patient urinary exosomes
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0147236
– volume: 46
  start-page: D276
  year: 2018
  ident: 2023013107225696100_bty527-B62
  article-title: lncRNASNP2: an updated database of functional SNPs and mutations in human and mouse lncRNAs
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkx1004
– volume: 38
  start-page: 1076
  year: 2014
  ident: 2023013107225696100_bty527-B18
  article-title: Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes
  publication-title: Cell Biol. Int
  doi: 10.1002/cbin.10301
– volume: 8
  start-page: 123
  year: 2011
  ident: 2023013107225696100_bty527-B43
  article-title: Prostate cancer: diagnostic performance of the PCA3 urine test
  publication-title: Nat. Rev. Urol
  doi: 10.1038/nrurol.2011.10
– volume: 9
  start-page: e87797
  year: 2014
  ident: 2023013107225696100_bty527-B95
  article-title: A network based method for analysis of lncRNA-disease associations and prediction of lncRNAs implicated in diseases
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0087797
– volume: 11
  start-page: 384
  year: 2015
  ident: 2023013107225696100_bty527-B53
  article-title: Construction of a lncRNA-PCG bipartite network and identification of cancer-related lncRNAs: a case study in prostate cancer
  publication-title: Mol. Biosyst
  doi: 10.1039/C4MB00439F
– volume: 21
  start-page: 959
  year: 2017
  ident: 2023013107225696100_bty527-B40
  article-title: Glioma cells promote angiogenesis through the release of exosomes containing long non-coding RNA POU3F3
  publication-title: Eur. Rev. Med. Pharmacol. Sci
– volume: 17
  start-page: 62
  year: 2017
  ident: 2023013107225696100_bty527-B89
  article-title: Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA
  publication-title: Cancer Cell Int
  doi: 10.1186/s12935-017-0430-x
– volume: 40
  start-page: 4
  year: 2015
  ident: 2023013107225696100_bty527-B33
  article-title: EVpedia: a community web resource for prokaryotic and eukaryotic extracellular vesicles research
  publication-title: Semin. Cell Dev. Biol
  doi: 10.1016/j.semcdb.2015.02.005
– volume: 527
  start-page: 329
  year: 2015
  ident: 2023013107225696100_bty527-B21
  article-title: Tumour exosome integrins determine organotropic metastasis
  publication-title: Nature
  doi: 10.1038/nature15756
– volume: 10
  year: 2017
  ident: 2023013107225696100_bty527-B57
  article-title: Extracellular vesicles-mediated noncoding RNAs transfer in cancer
  publication-title: J. Hematol. Oncol
  doi: 10.1186/s13045-017-0426-y
– volume: 6
  year: 2016
  ident: 2023013107225696100_bty527-B2
  article-title: Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes
  publication-title: Sci. Rep
  doi: 10.1038/srep24922
– volume: 44
  start-page: D980
  year: 2016
  ident: 2023013107225696100_bty527-B65
  article-title: Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkv1094
– volume: 30
  start-page: 34
  year: 2016
  ident: 2023013107225696100_bty527-B5
  article-title: Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
  publication-title: Genes Dev
  doi: 10.1101/gad.270959.115
– volume: 80
  start-page: 1111
  year: 2017
  ident: 2023013107225696100_bty527-B16
  article-title: The role of exosomes in pancreatic cancer microenvironment
  publication-title: Bull. Math. Biol
  doi: 10.1007/s11538-017-0254-9
– volume: 29
  start-page: 653
  year: 2016
  ident: 2023013107225696100_bty527-B71
  article-title: Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.03.004
– volume: 6
  start-page: 358
  year: 2017
  ident: 2023013107225696100_bty527-B37
  article-title: Accumulation of GAS5 in exosomes is a marker of apoptosis induction
  publication-title: Biomed. Rep
  doi: 10.3892/br.2017.848
– volume: 5
  start-page: e192
  year: 2016
  ident: 2023013107225696100_bty527-B90
  article-title: A serum-circulating long noncoding RNA signature can discriminate between patients with clear cell renal cell carcinoma and healthy controls
  publication-title: Oncogenesis
  doi: 10.1038/oncsis.2015.48
– volume: 1844
  start-page: 289
  year: 2014
  ident: 2023013107225696100_bty527-B32
  article-title: Hybrid modeling of the crosstalk between signaling and transcriptional networks using ordinary differential equations and multi-valued logic
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbapap.2013.05.007
– volume: 1
  start-page: 3
  year: 2016
  ident: 2023013107225696100_bty527-B20
  article-title: Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability
  publication-title: Noncoding RNA Res
  doi: 10.1016/j.ncrna.2016.06.001
– volume: 80
  start-page: 1539
  year: 2018
  ident: 2023013107225696100_bty527-B60
  article-title: Modelling the immune response to cancer: an individual-based approach accounting for the difference in movement between inactive and activated T cells
  publication-title: Bull. Math. Biol
  doi: 10.1007/s11538-018-0412-8
– volume: 46
  start-page: D106
  year: 2018
  ident: 2023013107225696100_bty527-B49
  article-title: exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkx891
– volume: 165
  start-page: 99
  year: 2018
  ident: 2023013107225696100_bty527-B66
  article-title: Interaction between the immune system and acute myeloid leukemia: a model incorporating promotion of regulatory T cell expansion by leukemic cells
  publication-title: Biosystems
  doi: 10.1016/j.biosystems.2018.01.006
– volume: 4
  start-page: 261
  year: 2013
  ident: 2023013107225696100_bty527-B36
  article-title: Extracellular vesicle-mediated transfer of a novel long noncoding RNA TUC339: a mechanism of intercellular signaling in human hepatocellular cancer
  publication-title: Genes Cancer
  doi: 10.1177/1947601913499020
– volume: 7
  start-page: 41544
  year: 2017
  ident: 2023013107225696100_bty527-B42
  article-title: Discovery of cancer driver long noncoding RNAs across 1112 tumour genomes: new candidates and distinguishing features
  publication-title: Sci. Rep
  doi: 10.1038/srep41544
– volume: 10
  start-page: e1001450
  year: 2012
  ident: 2023013107225696100_bty527-B28
  article-title: Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.1001450
– volume: 29
  start-page: 223
  year: 2018
  ident: 2023013107225696100_bty527-B10
  article-title: Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients
  publication-title: Ann. Oncol
  doi: 10.1093/annonc/mdx542
– volume: 6
  start-page: 1321455
  year: 2017
  ident: 2023013107225696100_bty527-B69
  article-title: A novel community driven software for functional enrichment analysis of extracellular vesicles data
  publication-title: J. Extracell. Vesicles
  doi: 10.1080/20013078.2017.1321455
– volume: 19
  start-page: 7642
  year: 2017
  ident: 2023013107225696100_bty527-B44
  article-title: Identifying the optimal anticancer targets from the landscape of a cancer-immunity interaction network
  publication-title: Phys. Chem. Chem. Phys
  doi: 10.1039/C6CP07767F
– volume: 2009
  start-page: bap008
  year: 2009
  ident: 2023013107225696100_bty527-B39
  article-title: miRo: a miRNA knowledge base
  publication-title: Database
  doi: 10.1093/database/bap008
– volume: 1838
  start-page: 2954
  year: 2014
  ident: 2023013107225696100_bty527-B81
  article-title: Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamem.2014.07.026
– volume: 7
  start-page: 894
  year: 2017
  ident: 2023013107225696100_bty527-B67
  article-title: Therapeutic targeting using tumor specific peptides inhibits long non-coding RNA HOTAIR activity in ovarian and breast cancer
  publication-title: Sci. Rep
  doi: 10.1038/s41598-017-00966-3
– volume: 11
  start-page: 126
  year: 2015
  ident: 2023013107225696100_bty527-B102
  article-title: Identification of cancer-related lncRNAs through integrating genome, regulome and transcriptome features
  publication-title: Mol. BioSyst
  doi: 10.1039/C4MB00478G
– volume: 12
  start-page: 664
  year: 2015
  ident: 2023013107225696100_bty527-B79
  article-title: Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3433
– volume: 7
  year: 2017
  ident: 2023013107225696100_bty527-B48
  article-title: Exploring functions of long noncoding RNAs across multiple cancers through co-expression network
  publication-title: Sci. Rep
– volume: 14
  start-page: 20170105.
  year: 2017
  ident: 2023013107225696100_bty527-B88
  article-title: Uncovering the underlying mechanism of cancer tumorigenesis and development under an immune microenvironment from global quantification of the landscape
  publication-title: J. R. Soc. Interface
  doi: 10.1098/rsif.2017.0105
– volume: 5
  start-page: 5439
  year: 2014
  ident: 2023013107225696100_bty527-B96
  article-title: Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.2118
– volume: 7
  year: 2016
  ident: 2023013107225696100_bty527-B12
  article-title: Extending gene ontology in the context of extracellular RNA and vesicle communication
  publication-title: J. Biomed. Semant
  doi: 10.1186/s13326-016-0061-5
– volume: 159
  start-page: 499
  year: 2014
  ident: 2023013107225696100_bty527-B9
  article-title: Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.051
– volume: 17
  start-page: 055021
  year: 2015
  ident: 2023013107225696100_bty527-B27
  article-title: Operating principles of Notch–Delta–Jagged module of cell–cell communication
  publication-title: N. J. Phys
  doi: 10.1088/1367-2630/17/5/055021
– volume: 36
  start-page: 113
  year: 2017
  ident: 2023013107225696100_bty527-B1
  article-title: Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells
  publication-title: J. Exp. Clin. Cancer Res
  doi: 10.1186/s13046-017-0587-0
– volume: 11
  start-page: 431
  year: 2007
  ident: 2023013107225696100_bty527-B59
  article-title: Bacterially derived 400 nm particles for encapsulation and cancer cell targeting of chemotherapeutics
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2007.03.012
– volume: 81
  start-page: 53
  year: 2016
  ident: 2023013107225696100_bty527-B98
  article-title: Analysis of lncRNAs expression in UVB-induced stress responses of melanocytes
  publication-title: J. Dermatol. Sci
  doi: 10.1016/j.jdermsci.2015.10.019
– volume: 22
  start-page: 1760
  year: 2012
  ident: 2023013107225696100_bty527-B19
  article-title: GENCODE: the reference human genome annotation for The ENCODE Project
  publication-title: Genome Res
  doi: 10.1101/gr.135350.111
– volume: 456
  start-page: 768
  year: 2015
  ident: 2023013107225696100_bty527-B85
  article-title: Effective internalization of U251-MG-secreted exosomes into cancer cells and characterization of their lipid components
  publication-title: Biochem. Biophys. Res. Commun
  doi: 10.1016/j.bbrc.2014.12.015
– volume: 12
  start-page: 1377
  year: 2014
  ident: 2023013107225696100_bty527-B84
  article-title: Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy
  publication-title: Mol. Cancer Res
  doi: 10.1158/1541-7786.MCR-13-0636
– volume: 7
  start-page: 78850
  year: 2016
  ident: 2023013107225696100_bty527-B15
  article-title: Identification of a serum circulating lncRNA panel for the diagnosis and recurrence prediction of bladder cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12880
– volume: 45
  start-page: 1895
  year: 2013
  ident: 2023013107225696100_bty527-B46
  article-title: Targeting long non-coding RNAs in cancers: progress and prospects
  publication-title: Int. J. Biochem. Cell Biol
  doi: 10.1016/j.biocel.2013.05.030
– volume: 16
  start-page: 1520
  year: 2015
  ident: 2023013107225696100_bty527-B78
  article-title: A BRCA1-interacting lncRNA regulates homologous recombination
  publication-title: EMBO Rep
  doi: 10.15252/embr.201540437
– volume: 174
  start-page: 63
  year: 2017
  ident: 2023013107225696100_bty527-B7
  article-title: Exosomes: therapy delivery tools and biomarkers of diseases
  publication-title: Pharmacol. Ther
  doi: 10.1016/j.pharmthera.2017.02.020
– volume: 27
  start-page: 172
  year: 2017
  ident: 2023013107225696100_bty527-B58
  article-title: Extracellular vesicles: unique intercellular delivery vehicles
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2016.11.003
– volume: 546
  start-page: 498
  year: 2017
  ident: 2023013107225696100_bty527-B29
  article-title: Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
  publication-title: Nature
  doi: 10.1038/nature22341
– volume: 6
  start-page: 1286095
  year: 2017
  ident: 2023013107225696100_bty527-B61
  article-title: Obstacles and opportunities in the functional analysis of extracellular vesicle RNA–an ISEV position paper
  publication-title: J. Extracell. Vesicles
  doi: 10.1080/20013078.2017.1286095
– volume: 159
  start-page: 1110
  year: 2014
  ident: 2023013107225696100_bty527-B92
  article-title: lncRNA directs cooperative epigenetic regulation downstream of chemokine signals
  publication-title: Cell
  doi: 10.1016/j.cell.2014.10.013
– volume: 355
  start-page: 6320
  year: 2017
  ident: 2023013107225696100_bty527-B52
  article-title: CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
  publication-title: Science
  doi: 10.1126/science.aah7111
– volume: 45
  start-page: D74
  year: 2017
  ident: 2023013107225696100_bty527-B64
  article-title: LincSNP 2.0: an updated database for linking disease-associated SNPs to human long non-coding RNAs and their TFBSs
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkw945
– volume: 127
  start-page: 1585
  year: 2014
  ident: 2023013107225696100_bty527-B82
  article-title: Modulation of hypoxia-signaling pathways by extracellular linc-RoR
  publication-title: J. Cell Sci
– volume: 124
  start-page: 580
  year: 2018
  ident: 2023013107225696100_bty527-B56
  article-title: Biobehavioral modulation of the exosome transcriptome in ovarian carcinoma
  publication-title: Cancer
  doi: 10.1002/cncr.31078
– volume: 20
  start-page: 4362
  year: 2016
  ident: 2023013107225696100_bty527-B93
  article-title: Exosomes mediated transfer of lncRNA UCA1 results in increased tamoxifen resistance in breast cancer cells
  publication-title: Eur. Rev. Med. Pharmacol. Sci
– volume: 11
  start-page: 291
  year: 2018
  ident: 2023013107225696100_bty527-B100
  article-title: Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer
  publication-title: Oncotargets Ther
  doi: 10.2147/OTT.S155134
– volume: 18
  start-page: 883
  year: 2012
  ident: 2023013107225696100_bty527-B70
  article-title: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
  publication-title: Nat. Med
  doi: 10.1038/nm.2753
– volume: 30
  start-page: 1116
  year: 2016
  ident: 2023013107225696100_bty527-B99
  article-title: Exosomal long noncoding RNAs are differentially expressed in the cervicovaginal lavage samples of cervical cancer patients
  publication-title: J. Clin. Lab. Anal
  doi: 10.1002/jcla.21990
– volume: 46
  start-page: D354
  year: 2018
  ident: 2023013107225696100_bty527-B75
  article-title: miRandola 2017: a curated knowledge base of non-invasive biomarkers
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkx854
– volume: 8
  start-page: 109861
  year: 2017
  ident: 2023013107225696100_bty527-B87
  article-title: Stromal cell extracellular vesicular cargo mediated regulation of breast cancer cell metastasis via ubiquitin conjugating enzyme E2 N pathway
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.22371
– volume: 490
  start-page: 406
  year: 2017
  ident: 2023013107225696100_bty527-B101
  article-title: Serum long non coding RNA MALAT-1 protected by exosomes is up-regulated and promotes cell proliferation and migration in non-small cell lung cancer
  publication-title: Biochem. Biophys. Res. Commun
  doi: 10.1016/j.bbrc.2017.06.055
– volume: 17
  start-page: 816
  year: 2015
  ident: 2023013107225696100_bty527-B13
  article-title: Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
  publication-title: Nature Cell Biology
  doi: 10.1038/ncb3169
– volume: 8
  start-page: 63461
  year: 2017
  ident: 2023013107225696100_bty527-B97
  article-title: Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.18831
– volume: 388
  start-page: 281
  year: 2017
  ident: 2023013107225696100_bty527-B51
  article-title: LncRNA SPRY4-IT1 sponges miR-101-3p to promote proliferation and metastasis of bladder cancer cells through up-regulating EZH2
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2016.12.005
– volume: 197
  start-page: 122
  year: 2018
  ident: 2023013107225696100_bty527-B45
  article-title: LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2018.02.006
– volume: 23
  start-page: 1429
  year: 2014
  ident: 2023013107225696100_bty527-B73
  article-title: Cellular phenotype and extracellular vesicles: basic and clinical considerations
  publication-title: Stem Cells Dev
  doi: 10.1089/scd.2013.0594
– volume: 101
  start-page: 12
  year: 2016
  ident: 2023013107225696100_bty527-B4
  article-title: Exosomal formulation enhances therapeutic response of celastrol against lung cancer
  publication-title: Exp. Mol. Pathol
  doi: 10.1016/j.yexmp.2016.05.013
– volume: 17
  start-page: 1600432
  year: 2017
  ident: 2023013107225696100_bty527-B54
  article-title: Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin
  publication-title: Proteomics
  doi: 10.1002/pmic.201600432
– volume: 1846
  start-page: 75
  year: 2014
  ident: 2023013107225696100_bty527-B26
  article-title: A comprehensive overview of exosomes as drug delivery vehicles - endogenous nanocarriers for targeted cancer therapy
  publication-title: Biochim. Biophys. Acta
– volume: 6
  start-page: e1362527
  year: 2017
  ident: 2023013107225696100_bty527-B80
  article-title: Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2017.1362527
– volume: 8
  start-page: e1002742.
  year: 2012
  ident: 2023013107225696100_bty527-B34
  article-title: Modeling protective anti-tumor immunity via preventative cancer vaccines using a hybrid agent-based and delay differential equation approach
  publication-title: PLoS Comput. Biol
  doi: 10.1371/journal.pcbi.1002742
– volume: 428
  start-page: 688
  year: 2016
  ident: 2023013107225696100_bty527-B30
  article-title: ExoCarta: a web-based compendium of exosomal cargo
  publication-title: J. Mol. Biol
  doi: 10.1016/j.jmb.2015.09.019
SSID ssj0051444
ssj0005056
Score 2.512255
SecondaryResourceType review_article
Snippet Abstract Motivation Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis...
Extracellular vesicles (EVs), including exosomes and microvesicles, are potent and clinically valuable tools for early diagnosis, prognosis and potentially the...
SourceID proquest
pubmed
crossref
oup
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 352
Title Exosomal lncRNAs and cancer: connecting the missing links
URI https://www.ncbi.nlm.nih.gov/pubmed/30649349
https://www.proquest.com/docview/2179391767
Volume 35
WOSCitedRecordID wos000459314900026&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVASL
  databaseName: Oxford Journals Open Access Collection
  customDbUrl:
  eissn: 1460-2059
  dateEnd: 20220930
  omitProxy: false
  ssIdentifier: ssj0005056
  issn: 1367-4803
  databaseCode: TOX
  dateStart: 19850101
  isFulltext: true
  titleUrlDefault: https://academic.oup.com/journals/
  providerName: Oxford University Press
– providerCode: PRVASL
  databaseName: Oxford Journals Open Access Collection
  customDbUrl:
  eissn: 1460-2059
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0005056
  issn: 1367-4803
  databaseCode: TOX
  dateStart: 19850101
  isFulltext: true
  titleUrlDefault: https://academic.oup.com/journals/
  providerName: Oxford University Press
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS8NAEF5qUfDi-1EfZQUvHmKT7iOJtyIWD1JFiuQWso9CoSbSpGL_vbPZpFJFtMeE2d0wM8l8k3khdMkAcgiPBY4WUjhUqNAJJA8dLrinwMLKpKxKe3nwB4MgisKnBnLrWpjvIfyQdMQ4q5qImsbFHVHMWdeUj8MJZmTB8DH6yulwTWcYewFIgNqRtqazd-CSun7nty2XLNNStdsP0Fkan_726o-9g7YqoIl7VjN2UUOne2jDjp6c76Pw7iPLs1egmKTyedDLcZIqLI0OTG-wNOkv0mREYwCIGHTB_FLAZbT3AA37d8Pbe6cao-BIStzC0UQlCdFUSgrunOKcKQUvMiFsJNgIjKSrAgmowi3FQzUPE7jhaipMVS0lh6iZZqk-RrgrKHe14AnAFKrUSEhPS0Y9P_EBtjC_hWjNwVhWLcbNpItJbEPdJF5mSmyZ0kLXi2VvtsfGXwuuQDz_pb2ohRgDt0w4JEl1Nsvjrvk2gbfKgebISnexpfHLQkLDkxVOOkWbgKZM9pnjsTPULKYzfY7W5XsxzqdttOZHQbtU10_Zyu6_
linkProvider Oxford University Press
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exosomal+lncRNAs+and+cancer%3A+connecting+the+missing+links&rft.jtitle=Bioinformatics+%28Oxford%2C+England%29&rft.au=Naderi-Meshkin%2C+Hojjat&rft.au=Lai%2C+Xin&rft.au=Amirkhah%2C+Raheleh&rft.au=Vera%2C+Julio&rft.date=2019-01-15&rft.issn=1367-4803&rft.eissn=1367-4811&rft.volume=35&rft.issue=2&rft.spage=352&rft.epage=360&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbty527&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_bioinformatics_bty527
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1367-4803&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1367-4803&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1367-4803&client=summon