Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

COVID-19-associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained viral dissemination and organ injury. A key explanation...

Full description

Saved in:

Bibliographic Details
Published in:	JCI insight Vol. 5; no. 17
Main Authors:	Remy, Kenneth E., Mazer, Monty, Striker, David A., Ellebedy, Ali H., Walton, Andrew H., Unsinger, Jacqueline, Blood, Teresa M., Mudd, Philip A., Yi, Daehan J., Mannion, Daniel A., Osborne, Dale F., Martin, R. Scott, Anand, Nitin J., Bosanquet, James P., Blood, Jane, Drewry, Anne M., Caldwell, Charles C., Turnbull, Isaiah R., Brakenridge, Scott C., Moldwawer, Lyle L., Hotchkiss, Richard S.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 03.09.2020
Subjects:	Adaptive Immunity - immunology Adolescent Adult Aged Aged, 80 and over Antibodies Betacoronavirus Case-Control Studies Coronavirus Infections - immunology Coronaviruses COVID-19 Critical Illness Cytokine Release Syndrome - immunology Cytokine storm Enzyme-linked immunosorbent assay Enzyme-Linked Immunospot Assay Female Healthy Volunteers Humans Immune response Immune status Immune Tolerance - immunology Immunity, Innate - immunology Immunoassay Immunosuppression Infections Innate immunity Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-6 - immunology Leukocytes (mononuclear) Lymphocytes Lymphocytes T Male Middle Aged Monocytes Monocytes - immunology Monocytes - metabolism Morbidity Mortality Pandemics Patients Plasma Pneumonia, Viral - immunology SARS-CoV-2 Sepsis Sepsis - immunology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Young Adult COVID-19 Adaptive immunity
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!