TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors

In recent years, chimeric antigen receptor-modified T cell (CAR T cell) therapy has proven to be a promising approach against cancer. Nonetheless, this approach still faces multiple challenges in eliminating solid tumors, one of which being the immunosuppressive tumor microenvironment (TME). Here, w...

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Vydané v:	JCI insight Ročník 5; číslo 4
Hlavní autori:	Tang, Na, Cheng, Chen, Zhang, Xingying, Qiao, Miaomiao, Li, Na, Mu, Wei, Wei, Xiao-Fei, Han, Weidong, Wang, Haoyi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States American Society for Clinical Investigation 27.02.2020
Predmet:	Antigens Cancer Cell therapy Chimeric antigen receptors CRISPR Cytokines Cytotoxicity Genes Immunological memory Ligands Lymphocytes Lymphocytes T Memory cells Solid tumors Transforming growth factor-b Tumor microenvironment Tumors Xenografts Cancer immunotherapy Oncology Therapeutics
ISSN:	2379-3708, 2379-3708
On-line prístup:	Získať plný text
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