Gene Expression in Relation to Exhaled Nitric Oxide Identifies Novel Asthma Phenotypes with Unique Biomolecular Pathways

Although asthma is recognized as a heterogeneous disease associated with clinical phenotypes, the molecular basis of these phenotypes remains poorly understood. Although genomic studies have successfully broadened our understanding in diseases such as cancer, they have not been widely used in asthma...

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Veröffentlicht in:	American journal of respiratory and critical care medicine Jg. 190; H. 12; S. 1363 - 1372
Hauptverfasser:	Modena, Brian D., Tedrow, John R., Milosevic, Jadranka, Bleecker, Eugene R., Meyers, Deborah A., Wu, Wei, Bar-Joseph, Ziv, Erzurum, Serpil C., Gaston, Benjamin M., Busse, William W., Jarjour, Nizar N., Kaminski, Naftali, Wenzel, Sally E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Thoracic Society 15.12.2014
Schlagworte:	Adult Asthma - genetics Asthma - metabolism Biomarkers Bronchi - cytology Bronchi - metabolism Case-Control Studies Female Gene Expression - genetics Humans Male Middle Aged Multigene Family - genetics Nitric Oxide - metabolism Oligonucleotide Array Sequence Analysis Original Phenotype Real-Time Polymerase Chain Reaction exhaled nitric oxide severe asthma clustering
ISSN:	1073-449X, 1535-4970, 1535-4970
Online-Zugang:	Volltext
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